Unusual Sites of Colorectal Cancer Metastasis

Hobdy, Erole M.; Ciesielski, Thomas; Kummar, Shivaani

doi:10.3816/ccc.2003.n.012

Cited by 14 publications

(18 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Caecal adenocarcinoma has been shown previously to metastasise to some unusual sites like retina [4], chin [5], cervical node [6], subcutaneous tissue [7], breast [8], oesophagus [9], spleen [10], pancreas [11], umbilicus [12], urinary bladder [13], uterus [14], vagina [15], penis [16], spermatic cord [17] and epididymis [18]. Tumors that usually metastasise to inguinal lymph nodes are malignant lymphomas and squamous cell carcinoma of vulva, penis and anus.…”

Section: Discussionmentioning

confidence: 98%

Inguinal lymphadenopathy secondary to adenocarcinoma of caecum: A case report

et al. 2009

View full text Add to dashboard Cite

AbstractVarious tumours have been reported to metastasise to inguinal lymph nodes. To our knowledge, caecal cancer has never been reported to metastasise to inguinal nodes. We present a case of a woman who had caecal cancer with large contralateral inguinal lymphadenopathy. She underwent right hemicolectomy with excision of the inguinal lymph node. Histology confirmed adenocarcinoma of caecum metastasising to contralateral inguinal lymph nodes.

show abstract

Section: Discussionmentioning

confidence: 98%

Inguinal lymphadenopathy secondary to adenocarcinoma of caecum: A case report

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Metastases as a result of adenocarcinoma of the colon have been less frequently described [9]. The bladder, urethra and ureter are rare sites of colonic metastases [2][3][4]; however, most studies describing metastases to the ureter are based upon postmortem cases [5]. With the increasing use of radiological imaging modalities such as CT and MRI [1], together with increasing survival rates of primary cancers, asymptomatic ureteric metastases are more likely to be diagnosed.…”

Section: Discussionmentioning

confidence: 99%

“…Common metastatic sites for adenocarcinoma of the colon are the liver and lungs, whereas the bladder, urethra and ureter are rare sites of colonic metastases [2][3][4]. However, most studies describing metastases to the ureter are based on post-mortem cases [5].…”

Section: Introductionmentioning

confidence: 99%

Synchronous and metachronous ureteric metastases from adenocarcinoma of the colon

et al. 2011

View full text Add to dashboard Cite

Primary adenocarcinoma of the ureter occurs in only <1%. Furthermore, metastatic carcinoma to the ureter is very rare and has been described to occur from breast, lung, stomach and prostate cancers. However, metastases to the ureter from colon cancers are extremely rare, and have been largely reported as incidental post-mortem cases. We describe two cases of asymptomatic ureteric metastases secondary to adenocarcinoma of the colon; one is synchronous, whilst the other is a metachronous ureteric metastasis. With the increasing use of radiological imaging modalities such as CT and MRI (Clin Imaging 2001;25:197-202, 2001), together with increasing survival rates of primary cancers, asymptomatic ureteric metastases are more likely to be diagnosed. In summary, metastatic ureteric carcinoma of colonic origin must be considered as a differential diagnosis when there is a radiological abnormality of the ureter in patients with a history of adenocarcinoma of the colon. This should be considered even in patients with colon adenocarcinoma who have previously undergone adjuvant chemotherapy with curative intent.

show abstract

“…The most common metastatic sites are the regional lymph nodes, liver, lungs, and peritoneum [1]. Uncommon metastasis of CRC were described such as skin, muscles, skull and thyroid [2][3][4][5][6]. Involvement of unusual sites with metastasis frequently occurs in the presence disseminated disease.…”

mentioning

confidence: 99%

“…Involvement of unusual sites with metastasis frequently occurs in the presence disseminated disease. Thus, the patient presented with widespread metastasis had poor prognosis [4]. Although all types of tumors lead to metastasis to skull hematogenous route, breast cancer and lung cancers are associated with the highest rate, skull metastases of CRC are quite rare [5].…”

mentioning

confidence: 99%

Parietal Bone Metastasis of Rectal Adenocarcinoma as an Initial Diagnosis of Recurrence: Case Report

Kaçan¹,

Mm²,

Na³

et al. 2014

SAJ Case Reports

View full text Add to dashboard Cite

Colorectal cancer (CRC) is a most common and lethal disease of the gastrointestinal tract [1]. CRC can usually spread by lymphatic and hematogenous routes. The most common metastatic sites are the regional lymph nodes, liver, lungs, and peritoneum [1]. Uncommon metastasis of CRC were described such as skin, muscles, skull and thyroid [2][3][4][5][6]. Involvement of unusual sites with metastasis frequently occurs in the presence disseminated disease. Thus, the patient presented with widespread metastasis had poor prognosis [4]. Although all types of tumors lead to metastasis to skull hematogenous route, breast cancer and lung cancers are associated with the highest rate, skull metastases of CRC are quite rare [5]. Parietal bone metastasis without vertebral bone metastasis from CRC is an unexpected situation. The most common presenting symptom of skull metastases is a visible, localized swelling of skull produced by growing tumor [7]. Herein, we report a case of patient with a visible, localized swelling of skull.A 44-year old man had diagnosed with adenocarcinoma of the rectum as a result of colonoscopic biopsy in July 2009. Fluoropyrimidine-based neoadjuvant chemoradiotherapy had performed. "Low Anterior Resection" was held in September 2009 and after surgery 4 cycles adjuvant chemotherapy had admitted. The patient was followed in remission until February 2012. He had presented with a mass approximately 6 cm in diameter located his temporoparietal region in February 2012. The mass had grown rapidly in 4 or 5 months. Because of tumour diameter and pain, he had applied to Neurosurgery Department. Magnetic resonance imaging (MRI) showed a 6.0x4.0 cm mass, extending from bottom of scalp and epidural space (Figure 1). The mass had excised with parietal bone. After histopathological evaluation of parietal bone, the diagnosis was metastatic adenocarcinoma. Immunohistochemical analysis was positive for TTF-1, CK-19, CK-20 and CDX2. The specimens were negative for PSA, CK-7, CD10, surfactant. The final diagnosis was metastatic adenocarcinoma of CRC. He applied to Medical Oncology Department in April 2012. Palliative radiotherapy was performed to parietal bone. After the radiotherapy to the parietal bone, infusional 5-fluorouracil, leucovorin, and irinotecan and bevacizumab (FOLFIRI-BEV) was planned but he refused chemotherapy. He applied to Medical Oncology Department because of neurological complaints in July 2012. After re-staging new metastatic lesions detected in lungs, brain metastasis. Bone scan revealed widespread skeletal metastasis. Palliative radiotherapy was performed to painful bone lesions. Due to poor performance status no chemotherapy applied and he had followed up with best supportive. The patient died 9 months after the diagnosis of parietal bone metastasis. The most common metastatic sites of colorectal cancer are the regional lymph nodes, liver, lung, and peritoneum. Parietal bone metastasis without vertebral bone metastasis from colorectal cancer is an unexpected situation. Herein, we report an unusua...

show abstract

Unusual Sites of Colorectal Cancer Metastasis

Cited by 14 publications

References 27 publications

Inguinal lymphadenopathy secondary to adenocarcinoma of caecum: A case report

Inguinal lymphadenopathy secondary to adenocarcinoma of caecum: A case report

Synchronous and metachronous ureteric metastases from adenocarcinoma of the colon

Parietal Bone Metastasis of Rectal Adenocarcinoma as an Initial Diagnosis of Recurrence: Case Report

Contact Info

Product

Resources

About