Unusual swelling of elastin

Lillie, Margo A.; Gosline, John M.

doi:10.1002/bip.10155

Cited by 15 publications

(17 citation statements)

References 16 publications

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“…9 The m e is the mass of elastin, v w is the partial specific volume of water at 37°C obtained from standard tables, c w is the hydration of the elastin in g water/g elastin, v suc is the partial specific volume of sucrose, c suc is the sucrose content of the elastin in g/g, v SDS is the partial specific volume of SDS set at 0.87 mL/g, 13 and c SDS is the SDS content of the elastin in g SDS/g elastin. We have defined elastin in pure water at 37°C as a reference state.…”

Section: Calculation Of Network and Non-network Volumesmentioning

confidence: 97%

“…While sample volume increases as the cube of sample length, the network volume increases in direct proportion to sample length. 9 This behavior has been described for elastin under a range of swelling conditions, including swelling in SDS. 9 Since changes in the volume of the network are dependent only on its length, the swelling of the sample can be used to calculate the changes in the network volume due to the loading or unloading of SDS and water; and from network volume the composition of the network can be inferred.…”

Section: Introductionmentioning

confidence: 94%

“…9 This behavior has been described for elastin under a range of swelling conditions, including swelling in SDS. 9 Since changes in the volume of the network are dependent only on its length, the swelling of the sample can be used to calculate the changes in the network volume due to the loading or unloading of SDS and water; and from network volume the composition of the network can be inferred. We found that the mechanical behavior of elastin in SDS could be accounted for in terms of the volume of water or sucrose solution in the network, supporting the third hypothesis.…”

Section: Introductionmentioning

confidence: 94%

“…9. The solution concentrations and the number of samples used for chemical analysis are given in Table I.…”

Section: Chemical Compositionmentioning

confidence: 99%

“…A sample of elastin swells three-dimensionally, 9 so V S can be calculated from the cube of the swelling ratio,…”

Section: Calculation Of Network and Non-network Volumesmentioning

confidence: 99%

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Effects of lipids on elastin's viscoelastic properties

Lillie

Gosline

2002

Biopolymers

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Sodium dodecyl sulfate (SDS) was used as a model lipid to identify the molecular basis of possible lipid-induced changes in the viscoelastic behavior of arterial elastin. The chemical composition of the elastin network and the interfibrillar space was calculated from the chemical content of the elastin sample and its swelling behavior. Viscoelastic behavior was measured in aqueous SDS and in SDS plus 1 M sucrose, a deswelling agent. Viscoelastic behavior was also measured in sucrose and potassium thiocyanate solutions to identify the effects of swelling and of changes in network composition exclusive of any direct SDS effects. The hydration of the elastin network decreased at low SDS levels and increased at higher SDS levels. The elastin was stiffer in the dehydrated network and less stiff in the hydrated network. However, once the degree of hydration exceeded that of elastin in pure water, no further decrease in stiffness was obtained despite continued increase in swelling. The stiffness of the network could be accounted for entirely by changes in network hydration. There was no evidence that SDS had any effect on elastin's conformation. We predict that arterial lipids will interact with elastin in a similar way and will have only small effects on elastin's viscoelastic behavior.

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Section: Calculation Of Network and Non-network Volumesmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 94%

“…9. The solution concentrations and the number of samples used for chemical analysis are given in Table I.…”

Section: Chemical Compositionmentioning

confidence: 99%

“…A sample of elastin swells three-dimensionally, 9 so V S can be calculated from the cube of the swelling ratio,…”

Section: Calculation Of Network and Non-network Volumesmentioning

confidence: 99%

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Effects of lipids on elastin's viscoelastic properties

Lillie

Gosline

2002

Biopolymers

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A constitutive model for lung mechanics and injury applicable to static, dynamic, and shock loading

Clayton

Freed

2020

Mech Soft Mater

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A continuum model for lung parenchyma is constructed. The model describes the thermomechanical response over a range of loading rates-from static to dynamic to shock waves-and a range of stress states, including isotropic expansion, triaxial extension, simple shear, and plane wave compression. Nonlinear elasticity, viscoelasticity, and damage are included, with the latter associated with changes of biological function as well as mechanical stiffness. A Gram-Schmidt decomposition of the deformation gradient leads to strain attributes that enter the thermodynamic potentials as state variables. A free energy function is designed for loading at low to moderate rates and tensile pressures, whereby the tissue response, with surface tension, is preeminent. An internal energy function is designed for wave propagation analysis, including shock waves, whereby compressibility of the air inside the alveoli is addressed via a composite stiffness based on a closed-cell assumption. The model accurately represents the response to triaxial loading, pressure relaxation, and dynamic torsion with relatively few parameters. Longitudinal wave speeds are reasonable for ranges of internal airway pressure and transpulmonary pressure. Airway pressure strongly affects the response to plane wave compression. Criteria for local injury and damage progression depend on a normalized energy density and its gradient, where the latter is paramount for impact problems involving fast pressure rises. Results suggest that local damage associated with edema is induced at load intensities much lower than those that would cause significant stiffness changes due to rupture, major tearing, or local collapse.

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