Unusual Transformation ofN-Arylbenzohydroxamic Acids Mediated by Osmium. Formation of Organometallic Complexes of Osmium(III)

Synthesis and X-ray diffraction structures of novel half-sandwich Os(ii)-and Ru(ii)-hydroxamate complexes

“…The benzanilide which was formed from the hydroxamate coordinated as a dianionic C,N-donor. 18 To our that the rate is 3-5 orders of magnitude smaller in Os complexes than in their corresponding ruthenium analogues. 11 In general, while (N,N) donor ligand containing Ru complexes typically have suitable kinetic inertness and therefore high antiproliferative activity, the corresponding Os complexes might be less active due to the above kinetic differences.…”

“…The benzanilide which was formed from the hydroxamate coordinated as a dianionic C,N-donor. 18 To our knowledge, there are no reports on Os complexes with (O,O) coordinated hydroxamate in the literature.…”

Cyclometalation Using d-Block Transition Metals: Fundamental Aspects and Recent Trends

“…chloride abstraction with NaPF 6 ) or upon using an anion that is only weakly coordinating like X = OTf, 318 C-H bond activation and cyclometalation of one of the phosphine substituents ensues. A variety of metal precursors of the general formula OsX 2 L n (n = 3, 4) has been successfully employed for cyclometalation, including OsBr 2 (bpy) 2 , 325 Os(tfa) 2 (CO)(PPh 3 ) 2 , OsH(tfa)(CO)(PPh 3 ) 2 , 326 and Os(R)Cl(CO)(PiPr 3 ) 2 . 327 Of particular note are the osmium(II) salts OsCl 3 (tterpy) (tterpy = 4'-p-tolyl-2,2':6',2''-terpyridine) and Os(OH)(NO 3 )(tterpy)(O 2 ), the latter in combination with hydrazine.…”

Hydroxamic Acids − An Intriguing Family of Enzyme Inhibitors and Biomedical Ligands

“…[85] Interestingly, an unusual transformation of N-arylbenzohydroxamic acids, mediated by osmium(), affords a family of cyclometalates in which the transformed hydroxamic acids are coordinated as doubly deprotonated benzanilides of osmium(). [86] …”