Hydrolysis of half-sandwich-type platinum metal cations with the general formula [M(η 6 -arene)(H 2 O) 3 ] 2+ {M = Ru, Os; η 6 -arene = benzene, toluene, 1-methyl-4-isopropylbenzene (p-cym), or 1,3,5-triisopropylbenzene (tri-iPr)} or [Ir(η 5 -Cp*)-(H 2 O) 3 ] 2+ (Cp* = pentamethylcyclopentadienyl anion) was studied in aqueous solution in the presence of 0.20 M KNO 3 or KCl as a background electrolyte to explore the effects of the type of metal ion, the moderately coordinating monodentate chloride ion, and the electron-donating ability of the arene ligand. Replacement of Ru by Os enhances the formation of the biologically less-active, triple hydroxido-bridged dimer, [{M(η 6 -arene)} 2 (μ 2 -OH) 3 ] + , whereas in the presence of [a]

Novel water soluble half-sandwich complexes of the general formulae [M(g 6 -p-cym)(ha)] 2 (CF 3 SO 3 ) 2 , [M(g 6 -p-cym)(ha)Cl] or [M(g 6 -p-cym)(ha)(py)]X (M = Os, Ru; ha = hydroxamate; py = pyridine; X = Cl 2 or CF 3 SO 3 2 ), incorporating metal-containing entities and hydroxamates both with potential anti-proliferative features, were prepared and characterized by elemental analysis, spectroscopy (NMR, IR) and ESI mass spectrometry. The X-ray crystal structure of (17) occurs, and the crystal and molecular structure has been determined by X-ray method. Complexes 1, 5-8, 10 and 14 were tested for their in vitro cytotoxicity, using human-derived ovarian cancer cell lines (A2780 and A2780 cisR), and showed no anti-proliferative effect in the concentration range (0-200 mM) studied.

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