Unveiling the future reservoir of anti-cancer molecule—Combretastatin A4 from callus and cell aggregate suspension culture of flame creeper (Combretum microphyllum): growth, exudation and elicitation studies

Pandey, Harshita; Pandey, Pallavi; Singh, Sailendra; Negi, Arvind S.; Banerjee, Sayan

doi:10.1007/s11240-020-01951-x

Cited by 2 publications

(1 citation statement)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 1995, the most important bibenzyl compounds (with respect to their anti-cancer potential), namely, combretastatins A-4 (CA-4), A-5 (CA-5), and A-6 (CA-6), were characterized from the stem wood of C. caffrum [162]. Later, combretastatin A-4 (CA-4) was identified from C. microphyllum [189]. Addition-ally, combretastatin A-1, combretastatin B-1, and the corresponding 2-O-β-D-glucosides of the two combretastatins were identified from the root of C. kraussii [163] (Figure 7).…”

Section: Stilbenoids (Bibenzyles and Phenanthrenes)mentioning

confidence: 99%

Ethnopharmacology, Antimicrobial Potency, and Phytochemistry of African Combretum and Pteleopsis Species (Combretaceae): A Review

et al. 2023

View full text Add to dashboard Cite

Bacterial and fungal resistance to antibiotics is of growing global concern. Plants such as the African Combretum and Pteleopsis species, which are used in traditional medicine for the treatment of infections, could be good sources for antimicrobial extracts, drug scaffolds, and/or antibiotic adjuvants. In African countries, plant species are often used in combinations as traditional remedies. It is suggested that the plant species enhance the effects of each other in these combination treatments. Thus, the multi-species-containing herbal medications could have a good antimicrobial potency. In addition, plant extracts and compounds are known to potentiate the effects of antibiotics. The objective of this review is to compile the information on the botany, ethnopharmacology, ethnobotany, and appearance in herbal markets of African species of the genera Combretum and Pteleopsis. With this ethnobotanical information as a background, this review summarizes the information on the phytochemistry and antimicrobial potency of the extracts and their active compounds, as well as their combination effects with conventional antibiotics. The databases used for the literature search were Scopus, Elsevier, EBSCOhost, PubMed, Google Scholar, and SciFinder. In summary, a number of Combretum and Pteleopsis species were reported to display significant in vitro antibacterial and antifungal efficacy. Tannins, terpenes, flavonoids, stilbenes, and alkaloids—some of them with good antimicrobial potential—are known from species of the genera Combretum and Pteleopsis. Among the most potent antimicrobial compounds are arjunglucoside I (MIC 1.9 µg/mL) and imberbic acid (MIC 1.56 µg/mL), found in both genera and in some Combretum species, respectively. The in vitro antimicrobial properties of the extracts and compounds of many Combretum and Pteleopsis species support their traditional medicinal uses.

show abstract

Section: Stilbenoids (Bibenzyles and Phenanthrenes)mentioning

confidence: 99%