Unveiling the growth mechanism of SiO2/Ag hybrid nanospheres and using for Surface Enhanced Raman Scattering detection

Huang, Jie; Zhou, Yong; Xu, Jian; Liang, Pei; Liu, Zu gang; Wang, Jie; De, Zhang; Dong, Qian; Shen, Wei; Zhuang, Song Lin

doi:10.1016/j.apsusc.2018.08.220

Cited by 16 publications

(8 citation statements)

References 34 publications

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“…As a response to this problem, hybrids/composites with AgNPs dispersed on carriers or supports have been studied to enhance antibacterial activity compared with sole AgNPs: it is of significance to seek the optimal choice of carriers to combine with AgNPs in order to construct ideal antibacterial agents. Various AgNPs-based nanocomposites with different structures and morphologies have been developed up to now, such as an amorphous silica matrix dispersed with AgNPs [38], AgNPs core@silica shell [39], mesoporous silicas loaded with AgNPs [40], hollow mesoporous silica spheres with AgNPs in the cavity [41,42], fibers coated with AgNPs [43], etc. Although extensive efforts have been devoted to fabricating a lot of these AgNPs-based nanocomposites involving different carriers’ structures, there are still few systematic investigations on the effects of structures on antibacterial performance [44].…”

Section: Introductionmentioning

confidence: 99%

Hydrophilic Silver Nanoparticles Loaded into Niosomes: Physical–Chemical Characterization in View of Biological Applications

Rinaldi

Favero

Moeller³

et al. 2019

Nanomaterials

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Silver nanoparticles (AgNPs) are widely used as antibacterial agents and anticancer drugs, but often their low stability limits their mass production and broad applications. The use of niosomes as a carrier to protect and envelop AgNPs gives a new perspective to solve these problems. In this study, AgNPs were functionalized with sodium 3-mercapto-1-propanesulfonate (3MPS) to induce hydrophilic behavior, improving loading in Tween 20 and Span 20 niosomes (NioTw20 and NioSp20, respectively). Entrapment efficiency was evaluated by UV analyses and is around 1–4%. Dimensions were investigated by means of dynamic light scattering (DLS) (<2RH> = 140 ± 4 nm and <2RH> = 251 ± 1 nm respectively for NioTw20 + AgNPs and NioSp20 + AgNPs) and were compared with those by atomic force microscopy (AFM) and small angle X ray scattering (SAXS) analyses. Stability was assessed in water up to 90 days, and both in bovine serum and human serum for up to 8 h. In order to characterize the local structure of niosomes, SAXS measurements have been performed on Tween 20 and Span 20 empty niosomes and loaded with AgNPs. The release profiles of hydrophilic probe calcein and lipophilic probe Nile Red were performed in HEPES buffer and in human serum. All these features contribute to conclude that the two systems, NioTw20 + AgNPs and NioSp20 + AgNPs, are suitable and promising in the field of biological applications.

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Section: Introductionmentioning

confidence: 99%

Hydrophilic Silver Nanoparticles Loaded into Niosomes: Physical–Chemical Characterization in View of Biological Applications

Rinaldi

Favero

Moeller³

et al. 2019

Nanomaterials

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“…to deposit silver nanoparticles on the surface of SiO2 MS, prepared Ag@SiO2, and the LOD to R6G was 10 −8 mol/L [33]. Compared with other SiO2 MS composites, our samples with the double monolayer structure have higher Raman enhancement performance with an LOD of 10 −16 mol/L for R6G analytes, and an AEF of ~2.3 × 10 13 .…”

Section: Raman Measurements With Different R6g Concentrationsmentioning

confidence: 91%

SiO2 Microsphere Array Coated by Ag Nanoparticles as Raman Enhancement Sensor with High Sensitivity and High Stability

Sha

Wang

Zhang

2022

Sensors

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In this paper, a monolayer SiO2 microsphere (MS) array was self-assembled on a silicon substrate, and monolayer dense silver nanoparticles (AgNPs) with different particle sizes were transferred onto the single-layer SiO2 MS array using a liquid–liquid interface method. A double monolayer “Ag@SiO2” with high sensitivity and high uniformity was prepared as a surface-enhanced Raman scattering (SERS) substrate. The electromagnetic distribution on the Ag@SiO2 substrate was analyzed using the Lumerical FDTD (finite difference time domain) Solutions software and the corresponding theoretical enhancement factors were calculated. The experimental results show that a Ag@SiO2 sample with a AgNPs diameter of 30 nm has the maximal electric field value at the AgNPs gap. The limit of detection (LOD) is 10−16 mol/L for Rhodamine 6G (R6G) analytes and the analytical enhancement factor (AEF) can reach ~2.3 × 1013. Our sample also shows high uniformity, with the calculated relative standard deviation (RSD) of ~5.78%.

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“…More recently, it has been demonstrated that ATRA inhibited proliferation and invasion in ovarian cancer [37], liver cancer [38], and lung cancer [39].…”

Section: Atramentioning

confidence: 99%

Current Trends in ATRA Delivery for Cancer Therapy

et al. 2020

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All-Trans Retinoic Acid (ATRA) is the most active metabolite of vitamin A. It is critically involved in the regulation of multiple processes, such as cell differentiation and apoptosis, by activating specific genomic pathways or by influencing key signaling proteins. Furthermore, mounting evidence highlights the anti-tumor activity of this compound. Notably, oral administration of ATRA is the first choice treatment in Acute Promyelocytic Leukemia (APL) in adults and NeuroBlastoma (NB) in children. Regrettably, the promising results obtained for these diseases have not been translated yet into the clinics for solid tumors. This is mainly due to ATRA-resistance developed by cancer cells and to ineffective delivery and targeting. This up-to-date review deals with recent studies on different ATRA-loaded Drug Delivery Systems (DDSs) development and application on several tumor models. Moreover, patents, pre-clinical, and clinical studies are also reviewed. To sum up, the main aim of this in-depth review is to provide a detailed overview of the several attempts which have been made in the recent years to ameliorate ATRA delivery and targeting in cancer.

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Unveiling the growth mechanism of SiO2/Ag hybrid nanospheres and using for Surface Enhanced Raman Scattering detection

Cited by 16 publications

References 34 publications

Hydrophilic Silver Nanoparticles Loaded into Niosomes: Physical–Chemical Characterization in View of Biological Applications

Hydrophilic Silver Nanoparticles Loaded into Niosomes: Physical–Chemical Characterization in View of Biological Applications

SiO2 Microsphere Array Coated by Ag Nanoparticles as Raman Enhancement Sensor with High Sensitivity and High Stability

Current Trends in ATRA Delivery for Cancer Therapy

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