Unveiling the importance of process parameters on droplet shrinkage and crystallization behaviors of easily crystalline material during spray drying

Lu, Wangxing; Wang, Shanshan; Lin, Ruohui; Xing, Yang; Zhang, Cheng; Liu, Wenjie

doi:10.1080/07373937.2020.1793772

Cited by 13 publications

(2 citation statements)

References 44 publications

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“…Three crystalline forms of MAN exist: α-, β-, and δ-. α-MAN showed characteristic peaks at 9.4°, 13.8°, and 17.3°; β-mannitol showed characteristic peaks at 10.6°, 14.7°, and 16.8°; and δ-mannitol showed a characteristic peak at 9.7° [ 32 , 33 ]. The sharp peaks at 10.6°, 14.7°, and 16.8° indicated that MAN is composed of β-mannitol ( Figure 8 A).…”

Section: Resultsmentioning

confidence: 99%

Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules

Kou

Cheng

et al. 2023

Molecules

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Agglomeration is an undesirable phenomenon that often occurs in spray-dried microcapsules powder. The objective of this work is to determine the best solution for spray-dried hydroxypropyl-β-cyclodextrin (HP-β-CD) microcapsules from four anticaking agents, namely calcium stearate (CaSt), magnesium stearate (MgSt), silicon dioxide (SiO2), and mannitol (MAN), and to explore their anticaking mechanisms. Our results showed that MAN was found to be the superior anticaking agent among those tested. When the MAN ratio is 12%, the microcapsules with a special Xanthium-type shape had higher powder flowability and lower hygroscopicity and exhibited good anticaking properties. Mechanism research revealed that CaSt, MgSt, and SiO2 reduce hygroscopicity and caking by increasing the glass transition temperature of the microcapsules, while MAN prevents the hydroxyl group of HP-β-CD from combining with water molecules in the air by a crystal outer-layer on the microcapsule surface.

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Section: Resultsmentioning

confidence: 99%

Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules

Kou

Cheng

et al. 2023

Molecules

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“…These drying conditions are recognized for producing powdered materials with positive characteristics such as longer shelf life, secure handling (according to their flow properties) and convenience of consumption (Arepally et al, 2020a(Arepally et al, , 2020b. Regarding ballooning, some investigators have suggested that this phenomenon is typical of products obtained by spray-drying, and its presence is due to shrinkage of the particles during drying process, either by the rapid evaporation and high pressure found inside the particles or by diffusion of solutes in the droplet (Nunes et al, 2018;Cancino-Castillo et al, 2020;Lu et al, 2020). Additionally, the absence of visual cracks or fractures on the dry capsule surface suggests appropriated protection of probiotic bacteria due to a minimal or non-existing air permeability of dry capsules (Nunes et al, 2018).…”

Section: Morphological Analysis Of the Microcapsules Spray-driedmentioning

confidence: 99%

Physicochemical characteristics and survivability of Lactobacillus paracasei encapsulated by a gum arabic-pectin mixture as wall material and added to fresh panela cheese

Jiménez‐Fernández¹,

Perez-Tirado²,

Peredo-Lovillo³

et al. 2021

RMIQ

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Development of a Spray-Dried Formulation of Peptide-DNA Nanoparticles into a Dry Powder for Pulmonary Delivery Using Factorial Design

et al. 2022

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Background Gene therapy via pulmonary delivery holds the potential to treat various lung pathologies. To date, spray drying has been the most promising method to produce inhalable powders. The present study determined the parameters required to spray dry nanoparticles (NPs) that contain the delivery peptide, termed RALA (N-WEARLARALARALARHLARALARALRACEA-C), complexed with plasmid DNA into a dry powder form designed for inhalation. Methods The spray drying process was optimised using full factorial design with 19 randomly ordered experiments based on the combination of four parameters and three centre points per block. Specifically, mannitol concentration, inlet temperature, spray rate, and spray frequency were varied to observe their effects on process yield, moisture content, a median of particle size distribution, Z-average, zeta potential, encapsulation efficiency of DNA NPs, and DNA recovery. The impact of mannitol concentration was also examined on the spray-dried NPs and evaluated via biological functionality in vitro. Results The results demonstrated that mannitol concentration was the strongest variable impacting all responses apart from encapsulation efficiency. All measured responses demonstrated a strong dependency on the experimental variables. Furthermore, spray drying with the optimal variables in combination with a low mannitol concentration (1% and 3%, w/v) produced functional RALA/pDNA NPs. Conclusion The optimal parameters have been determined to spray dry RALA/pDNA NPs into an dry powder with excellent biological functionality, which have the potential to be used for gene therapy applications via pulmonary delivery.

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Unveiling the importance of process parameters on droplet shrinkage and crystallization behaviors of easily crystalline material during spray drying

Cited by 13 publications

References 44 publications

Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules

Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules

Physicochemical characteristics and survivability of Lactobacillus paracasei encapsulated by a gum arabic-pectin mixture as wall material and added to fresh panela cheese

Development of a Spray-Dried Formulation of Peptide-DNA Nanoparticles into a Dry Powder for Pulmonary Delivery Using Factorial Design

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