Up-regulation of circ_LARP4 suppresses cell proliferation and migration in ovarian cancer by regulating miR-513b-5p/LARP4 axis

Lin, Wumei; Yé, Haiyan; You, Keli; Chen, Le

doi:10.1186/s12935-019-1071-z

Cited by 39 publications

(28 citation statements)

References 27 publications

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“…Additionally, Lin et al discovered that circRNA expression was significantly decreased in OvCa cell lines compared with the normal group. Additionally, circLARP4 could upregulate its host gene LARP4 posttranscriptionally by sponging miR-513b-5p, thereby inhibiting cell proliferation and migration [81]. Overall, circLARP4 suppressed the development of OvCa via the miR-513b-5p/LARP4 axis, providing a promising therapeutic target for OvCa treatment.…”

Section: Hsa_circ_101057mentioning

confidence: 96%

The emerging roles of circular RNAs in ovarian cancer

et al. 2020

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Circular RNA (circRNA) is a novel class of regulatory noncoding RNA (ncRNA) molecules with a unique covalently closed loop structure. Next-generation sequencing shows that thousands of circRNAs are widely and stably expressed in multiple eukaryotes. As novel regulatory ncRNAs, circRNAs possess several specific molecular functions, including regulating gene transcription and translation, acting as miRNA sponges, and interacting with functional proteins. Ovarian cancer (OvCa) is one of the most aggressive malignant diseases affecting the lives of thousands of women worldwide, and the majority of OvCa cases are diagnosed at advanced stages. Accumulating evidence has revealed the significant roles of circRNAs in the occurrence and progression of OvCa, indicating the function of circRNAs as promising biomarkers and their therapeutic relevance in this disease. This review aims to summarize the mechanisms by which circRNAs mediate OvCa progression as well as their diagnostic and prognostic values in OvCa.

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Section: Hsa_circ_101057mentioning

confidence: 96%

The emerging roles of circular RNAs in ovarian cancer

et al. 2020

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“…Some circRNAs exert their tumor-suppressive roles in OC cells [141][142][143][144][145][146][147][148][149][150] (Table 2 and Figure 4). According to these reports, the "miRNA" sponge seems to be the most common mechanism by which circRNAs regulate the malignant properties of OC cells.…”

Section: Circrnas As Tumor Suppressors In Ocmentioning

confidence: 99%

The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

Dong

Xiong

et al. 2020

Cancers

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Circular RNAs (circRNAs) are covalently closed, endogenous non-coding RNAs and certain circRNAs are linked to human tumors. Owing to their circular form, circRNAs are protected from degradation by exonucleases, and therefore, they are more stable than linear RNAs. Many circRNAs have been shown to sponge microRNAs, interact with RNA-binding proteins, regulate gene transcription, and be translated into proteins. Mounting evidence suggests that circRNAs are dysregulated in cancer tissues and can mediate various signaling pathways, thus affecting tumorigenesis, metastasis, and remodeling of the tumor microenvironment. First, we review the characteristics, biogenesis, and biological functions of circRNAs, and describe various mechanistic models of circRNAs. Then, we provide a systematic overview of the functional roles of circRNAs in gynecological cancers. Finally, we describe the potential future applications of circRNAs as biomarkers for prognostic stratification and as therapeutic targets in gynecological cancers. Although the function of most circRNAs remains elusive, some individual circRNAs have biologically relevant functions in cervical cancer, ovarian cancer, and endometrial cancer. Certain circRNAs have the potential to serve as biomarkers and therapeutic targets in gynecological cancers.

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“…Li et al proved that circRNA CDR1as was an oncogenic factor in nonsmall-cell lung cancer [ 6 ], and Lin and Cai claimed that circ-EGLN3 enhanced the proliferation and aggressiveness of renal cell carcinoma cells [ 7 ]. Circ_LARP4 was shown to inhibit ovarian cancer cell proliferation and migration [ 8 ], and the anticancer role of circMTO1 was demonstrated in rectal cancer [ 9 ]. Many dysregulated circRNAs have been found in GC tissues [ 10 ], including the downregulated circKIAA0907 (has_circ_0005758) [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

CircKIAA0907 Retards Cell Growth, Cell Cycle, and Autophagy of Gastric Cancer In Vitro and Inhibits Tumorigenesis In Vivo via the miR-452-5p/KAT6B Axis

et al. 2020

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Background The significant roles of circular ribonucleic acids (RNAs) in cancers have been discussed in many studies. This report aimed to investigate the biological functions of circKIAA0907 and its action mechanism in gastric cancer (GC). Material/Methods Relative RNA expression levels were determined using quantitative real-time polymerase chain reaction (qRT-PCR). The examination of cell proliferation was performed via 3-(4, 5-dimethylthiazol-2-y1)-2, 5-diphenyl tetrazolium bromide assay. Flow cytometry was used to analyze the apoptosis rate and cell cycle. Protein levels were quantified using western blot. Biotinylated RNA pull-down assay was used to find the microRNA target of circKIAA0907; target binding was validated through dual-luciferase reporter assay. The assay in vivo was executed via a xenograft tumor model to explore the role of circKIAA0907 in GC. Results CircKIAA0907 was downregulated in GC and had higher stability than its linear isoform. Functionally, circKIAA0907 upregulation resulted in the repression of proliferation, cell cycle, and autophagy and promotion of apoptosis in GC cells. Mechanistically, circKIAA0907 bound to miR-452-5p as a specific sponge for it; lysine acetyltransferase 6B ( KAT6B ) was a target gene of miR-452-5p, so circKIAA0907 elevated KAT6B levels via sponging miR-452-5p. Reversion assays indicated that circKIAA0907 served as a tumor inhibitor by inhibiting miR-452-5p and increasing KAT6B; miR-452-5p inhibition impeded GC development by upregulating KAT6B. The miR-452-5p/KAT6B axis was also accountable for circKIAA0907-induced tumorigenesis suppression in vivo . Conclusions This work demonstrated that circKIAA0907 has diagnostic and therapeutic value in GC by acting as an oncogenic molecule via the miR-452-5p/KAT6B axis.

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Up-regulation of circ_LARP4 suppresses cell proliferation and migration in ovarian cancer by regulating miR-513b-5p/LARP4 axis

Cited by 39 publications

References 27 publications

The emerging roles of circular RNAs in ovarian cancer

The emerging roles of circular RNAs in ovarian cancer

The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

CircKIAA0907 Retards Cell Growth, Cell Cycle, and Autophagy of Gastric Cancer In Vitro and Inhibits Tumorigenesis In Vivo via the miR-452-5p/KAT6B Axis

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