Up-regulation of neprilysin mediates the protection of fructo-oligosaccharides against Alzheimer's disease

Abstract

<p>FOS attenuate cognitive impairment and alleviate Aβ accumulation in the brain of AD model mice. The regulation of HDAC2 on NEP plays an important role in the anti-AD effect of FOS.</p>

A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer’s Pathogenesis—And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder

“…Exercise training has been shown to have this effect in mice, whereas brain hypoperfusion or hypoxia tends to reduce neprilysin expression-an effect which might mediate in part the increased risk for AD that accompanies cerebrovascular disease [171][172][173]. Other reports indicate that oral administration of the green tea catechin epigallocatechin-3-gallate (EGCG) or prebiotic fructo-oligosaccharides can increase brain expression of neprilysin in AD model mice, whereas vitamin D deficiency can decrease brain neprilysin expression in mice [174][175][176]. These intriguing leads merit follow up.…”

Gut Microbiota and its Metabolites: Bridge of Dietary Nutrients and Alzheimer’s Disease

“…Multiple animal studies have demonstrated the protective effects of prebiotic administration on Aβ deposition, synaptic plasticity, and neuroinflammation markers, as well as on alterations in behavior and the microbiome and its metabolites in different animal models. For instance, in APP/PS1 transgenic mice, the administration of fructooligosaccharides alleviates Aβ accumulation and ameliorates cognitive deficits and neurodegeneration by modulating the gut microbiota [ 183 , 184 ]. In addition, dietary inulin intervention increases the abundance of beneficial microbiota and promotes the production of SCFAs and tryptophan-derived metabolites, indicating its potential to prevent AD [ 185 ].…”

Bioactive polysaccharides and oligosaccharides from garlic (Allium sativum L.): Production, physicochemical and biological properties, and structure–function relationships

“…Antioxidant, immunostimulatory activity, modulating the intestinal microbiota Perera et al, 2018;Zeng et al, 2012;Zhao, Cheng, et al, 2019 Ganoderma lucidum polysaccharides A glucan consisted of a mixed (1→3), ( 1→4 Immuno-enhancing, Antioxidant hypolipidemic, anti-lipidperoxidant activity Kang et al, 2019;Wang, Liu, et al, 2017; Lycium barbarum polysaccharides A main chain composed of Hypoglycemic, antifatigue, immunomodulatory activity Liu et al, 2016;Tang et al, 2015;Zhang, Li, et al, 2014; anti-Alzheimer's disease Kumar et al, 2015;Mao et al, 2015a;Singh et al, 2016;Wu et al, 2020 ( Bifidogenic, immunostimulatory, anti-obesity effect Coulier et al, 2009;Mistry et al, 2020;Vulevic et al, 2015;Walton et al, 2012 Xylooligosaccharides insulin resistance-alleviation effect Chen et al, 2010;Fei et al, 2014;Zartl et al, 2018 and biological activities of some polysaccharides and oligosaccharides from natural plant sources. Differences in molecular weight (MW), monosaccharide composition and sequence, glycosidic bond and its position, type and ...…”