Up-regulation of PPARγ, Nrf2 and HO-1 in microglia activated by thrombin

Hang, Hang; Wang, Likun; Wu, Guofeng; Ren, Siying

doi:10.1016/j.hest.2020.04.001

Brain Hemorrhages

2020

DOI: 10.1016/j.hest.2020.04.001

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Up-regulation of PPARγ, Nrf2 and HO-1 in microglia activated by thrombin

Hang Hang

Likun Wang

Guofeng Wu

et al.

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Cited by 2 publications

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“…Nrf2 as a transcription factor control the expression of antioxidant genes, such as HO-1 [ 67 , 69 ]. The Nrf2 pathway by PPARγ stimulation can decrease oxidative-stress [ 68 , 69 ]. The protective effect of pentahydroxy flavone against arsenic-induced myocardial injury appears to be via up-regulation of the PPARγ/Nrf2 signaling pathway [ 70 ].…”

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Madhuca indica: A Review on the Phytochemical and Pharmacological Aspects

et al. 2023

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Madhuca indica J.F. Gmel. (family: Sapotaceae), commonly known as Mahua in Indian dialects, occupies the importance as one of the fuel-efficient, energy-saving plant species. Extensive studies showed that the presence of phytochemicals e.g., carbohydrates, fatty acids, flavonoids, saponins, steroids, triterpenoids and glycosidic compounds in the extract of this species. Pharmacologically, it has been used against various disorders in indigenous system of medicine, inckuding antioxidant, anti-inflammatory, anticancer, hepatoprotective, anti-diabetic and wound healing activities. This review highlights various pharmacological activities, phytochemistry and importance of M. indica plant for medicine.

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Madhuca indica: A Review on the Phytochemical and Pharmacological Aspects

et al. 2023

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Targeting PPARs Signaling Pathways in Cardiotoxicity by Natural Compounds

2022

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Up-regulation of PPARγ, Nrf2 and HO-1 in microglia activated by thrombin

Cited by 2 publications

References 29 publications

Madhuca indica: A Review on the Phytochemical and Pharmacological Aspects

Madhuca indica: A Review on the Phytochemical and Pharmacological Aspects

Targeting PPARs Signaling Pathways in Cardiotoxicity by Natural Compounds

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