Up-regulation of Wip1 involves in neuroinflammation of retinal astrocytes after optic nerve crush via NF-κB signaling pathway

Zhong, Haibin; Cui, Ling; Xu, Fan; Chen, Lifei; Jiang, Li; Huang, Hui; Xu, Jiping; Zhao, Xin; Li, Li; Zeng, Siming; Li, Min

doi:10.1007/s00011-016-0952-z

Cited by 16 publications

(11 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The elevation of these cytokine can be linked to the ability of Wip1 to regulate p53 and NF k B pathways. 40,41 These data suggest that Wip1 in immune cells intrinsically controls the sensitivity to DSS-induced colitis through regulation of cytokine production. Yet, the deficiency in Wip1 activity is associated with more severe inflammatory response.…”

Section: Wip1 In Regulation Of Immune Responsementioning

confidence: 89%

DNA damage-induced phosphatase Wip1 in regulation of hematopoiesis, immune system and inflammation

et al. 2017

View full text Add to dashboard Cite

PP2C serine–threonine phosphatase, Wip1, is an important regulator of stress response. Wip1 controls a number of critical cellular functions: proliferation, cell cycle arrest, senescence and programmed cell death, apoptosis or autophagy. Ppm1d, the gene encoding Wip1 phosphatase, is expressed in hematopoietic progenitors, stem cells, neutrophils, macrophages B and T lymphocytes in bone marrow and peripheral blood. The Wip1−/− mice display immunodeficiency, abnormal lymphoid histopathology in thymus and spleen, defects in B- and T-cell differentiation, as well as susceptibility to viral infection. At the same time, Wip1 knockout mice exhibit pro-inflammatory phenotype in skin and intestine in the model of inflammatory bowel disease (IBD) with elevated levels of inflammation-promoting cytokines TNF-α, IL-6, IL-12, IL-17. Several Wip1 downstream targets can mediate Wip1 effects on hematopoietic system including, p53, ATM, p38MAPK kinase, NFkB, mTOR. Here, we summarized the current knowledge on the role of Wip1 in the differentiation of various hematopoietic lineages and how Wip1 deficiency affects the functions of immune cells.

show abstract

Section: Wip1 In Regulation Of Immune Responsementioning

confidence: 89%

DNA damage-induced phosphatase Wip1 in regulation of hematopoiesis, immune system and inflammation

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Only left optic nerve of the rats was crushed as described in previous studies [39, 49] with slight modification. Briefly, after general anesthesia induced by 10 % chloral hydrate, the ON was exposed and isolated after the gently rotated downward in the orbit.…”

Section: Methodsmentioning

confidence: 99%

Wogonin prevents TLR4-NF-κB-medicated neuro-inflammation and improves retinal ganglion cells survival in retina after optic nerve crush

Yang

et al. 2016

Oncotarget

Self Cite

View full text Add to dashboard Cite

Chronic neuro-inflammation is involved in the death of retinal ganglion cells (RGCs) in glaucoma. The aim of this study is to determine whether wogonin can suppress inflammatory responses and rescue RGCs death after optic nerve crush (ONC), an ideal animal model of glaucoma. Wogonin was administered intraperitoneally 10 min after establishment of ONC model. In this study, wogonin treatment reduced RGCs loss and inhibited RGCs apoptosis demonstrated by the increased Brn3a labeling RGCs at day 14 and the decreased cleaved caspase-3 expression at day 7 after ONC, respectively. In ONC model, number of GFAP-positive glial cells and iba1-positive microglial cells were increased, combined of the elevated level of pro-inflammatory cytokines released in retina at day 7. However, most of these responses were inhibited after wogonin treatment. The level of TLR4 expression, NF-κB-P65 nucleus location and NF-κB-P65 phosphorylation were increased in retina at day 1 after ONC, which was significantly reduced after wogonin treatment. These results demonstrated that wogonin protected RGCs survival and suppressed neuro-inflammation in retina after ONC by inhibiting TLR4-NF-κB pathways. We conclude that wogonin could be a possible strategy for the treatment of glaucoma.

show abstract

“…We further demonstrated that Wip1 can modulate neutrophil function to regulate intestinal ischemia/reperfusion injury (26, 37) and inflammatory bowel diseases in a p38 MAPK-dependent manner (25). Moreover, Wip1 can also participate in neuro-inflammation through controlling tumor necrosis factor (TNF)-α synthesis (38) or NF-κB function (39). Further studies identified the interplay between Wip1 and NF-κB which plays an important role in cellular inflammatory response.…”

Section: Wip1 In Inflammationmentioning

confidence: 99%

Phosphatase Wip1 in Immunity: An Overview and Update

et al. 2017

View full text Add to dashboard Cite

Wild-type p53-induced phosphatase 1 (Wip1) is a newly identified serine/threonine phosphatase, which belongs to the PP2C family. Due to its involvement in stress-induced networks and overexpression in human tumors, primary studies have mainly focused on the role of Wip1 in tumorigenesis. It now has also been implicated in regulating several other physiological processes such as organism aging and neurogenesis. Recent evidence highlights a new role of Wip1 in controlling immune response through regulating immune cell development and function, as well as through the interplay with inflammatory signaling pathways such NF-κB and p38 mitogen-activated protein kinase. In this short review, we will give an overview of Wip1 in immunity to better understand this important phosphatase.

show abstract

Up-regulation of Wip1 involves in neuroinflammation of retinal astrocytes after optic nerve crush via NF-κB signaling pathway

Abstract: These data were consistent with the hypothesis that Wip1 was implicated in neuroinflammation of retinal astrocytes after ONC via NF-κB signaling pathway.

Cited by 16 publications

References 23 publications

DNA damage-induced phosphatase Wip1 in regulation of hematopoiesis, immune system and inflammation

DNA damage-induced phosphatase Wip1 in regulation of hematopoiesis, immune system and inflammation

Wogonin prevents TLR4-NF-κB-medicated neuro-inflammation and improves retinal ganglion cells survival in retina after optic nerve crush

Phosphatase Wip1 in Immunity: An Overview and Update

Contact Info

Product

Resources

About