Upconversion Fluorescence-SERS Dual-Mode Tags for Cellular and in Vivo Imaging

Xiao-Juan, Niu; Chen, Haiyan; Wang, Yunqing; Wang, Wenhai; Sun, Xiaofeng; Chen, Lingxin

doi:10.1021/am500411m

Cited by 113 publications

(74 citation statements)

References 41 publications

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“…The new nano-carriers that have rapidly emerged as drug delivery systems may overcome these limitations. [30][31][32][33][34][35][36][37][38] The drug delivery mechanism of nano-carriers depends on enhanced permeability and retention (EPR) effects. The anticancer drugs are either conjugated to the nano-carriers or packaged as nanocapsules.…”

Section: Jaebum Choomentioning

confidence: 99%

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

et al. 2017

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Surgical resection of solid tumors is currently the gold standard and preferred therapeutic strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting the rapid growth of tumor cells and these two approaches are often combined to enhance treatment efficacy. However, surgery and chemotherapy inevitably lead to severe side effects and high systemic toxicity, which in turn results in poor prognosis. Precision medicine has promoted the development of treatment modalities that are developed to specifically target and kill tumor cells. Advances in in vivo medical imaging for visualizing tumor lesions can aid diagnosis, facilitate surgical resection, investigate therapeutic efficacy, and improve prognosis. In particular, the modality of fluorescence imaging has high specificity and sensitivity and has been utilized for medical imaging. Therefore, there are great opportunities for chemists and physicians to conceive, synthesize, and exploit new chemical probes that can image tumors and release chemotherapy drugs in vivo. This review focuses on small molecular ligand-targeted fluorescent imaging probes and fluorescent theranostics, including their design strategies and applications in clinical tumor treatment. The progress in chemical probes described here suggests that fluorescence imaging is a vital and rapidly developing field for interventional surgical imaging, as well as tumor diagnosis and therapy.

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Section: Jaebum Choomentioning

confidence: 99%

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

et al. 2017

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“…[8][9][10][11][12] Especially, SERS-fluorescence dual mode nanoprobes were expected to improve the imaging quality and detection sensitivity of the fluorescence signal, quick indicator; meanwhile SERS could help to distinguish specific targets in multiplex interactions. 13,14 Utilizing SERS-fluorescence dual mode nanoprobes can be an extremely sensitive analytic tool in a variety of biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Dual-Mode SERS-Fluorescence Immunoassay Using Graphene Quantum Dot Labeling on One-Dimensional Aligned Magnetoplasmonic Nanoparticles

Zou

Zhou

Tran

et al. 2015

ACS Appl. Mater. Interfaces

106

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A novel dual-mode immunoassay based on surface-enhanced Raman scattering (SERS) and fluorescence was designed using graphene quantum dot (GQD) labels to detect a tuberculosis (TB) antigen, CFP-10, via a newly developed sensing platform of linearly aligned magnetoplasmonic (MagPlas) nanoparticles (NPs). The GQDs were excellent bilabeling materials for simultaneous Raman scattering and photoluminescence (PL). The one-dimensional (1D) alignment of MagPlas NPs simplified the immunoassay process and enabled fast, enhanced signal transduction. With a sandwich-type immunoassay using dual-mode nanoprobes, both SERS signals and fluorescence images were recognized in a highly sensitive and selective manner with a detection limit of 0.0511 pg mL(-1).

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“…This surfaceenhanced resonant Raman scattering effect is a benefit for producing a higher enhancement factor. 33,34 For AuNR, the longitude SPR peak at 780 nm matched the maximum absorption of DTTC (764 nm); thus only DTTC exhibited strong Raman intensity. Second, the coupling between the AuNR core and the external porous Ag/Au shell renders the inherent EM hot spots.…”

Section: Acs Applied Materials and Interfacesmentioning

confidence: 93%

Phospholipid Encapsulated AuNR@Ag/Au Nanosphere SERS Tags with Environmental Stimulus Responsive Signal Property

Wang

et al. 2016

ACS Appl. Mater. Interfaces

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Surface-enhanced Raman scattering (SERS) tags draw much attention due to the ultrasensitivity and multiplex labeling capability. Recently, a new kind of SERS tags was rationally designed by encapsulating metal nanoparticles with phospholipid bilayers, showing great potential in theranostics. The lipid bilayer coating confers biocompatibility and versatility to changing surface chemistry of the tag; however, its "soft" feature may influence SERS signal stability, which is rarely investigated. Herein, we prepared phospholipidcoated AuNR@Ag/Au nanosphere SERS tags by using three different kinds of Raman reporters, i.e., thio-containing 4-nitrothiophenol (NT), nitrogen-containing hydrophobic chromophore cyanine 7 monoacid (Cy7), and alkyl chain− chromophore conjugate 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindodicarbocyanine (DiD). It was found that signal responses were different upon additional stimulation which the tags may encounter in theranostic applications including the presence of detergent Triton X-100, lipid membrane, and photothermal treatment. Living-cell imaging also showed signal changing distinction. The different SERS signal performances were attributed to the different Raman reporter releasing behaviors from the tags. This work revealed that Raman reporter structure determined signal stability of lipid-coated SERS tags, providing guidance for the design of stimulus responsive tags. Moreover, it also implied the potential of SERS technique for real time drug release study of lipid based nanomedicine.

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Upconversion Fluorescence-SERS Dual-Mode Tags for Cellular and in Vivo Imaging

Cited by 113 publications

References 41 publications

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

Dual-Mode SERS-Fluorescence Immunoassay Using Graphene Quantum Dot Labeling on One-Dimensional Aligned Magnetoplasmonic Nanoparticles

Phospholipid Encapsulated AuNR@Ag/Au Nanosphere SERS Tags with Environmental Stimulus Responsive Signal Property

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