Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics

Chen, Guanying; Qiu, Hailong; Prasad, Paras N.; Chen, Xiaoyuan

doi:10.1021/cr400425h

Cited by 2,299 publications

(1,897 citation statements)

References 471 publications

(1,047 reference statements)

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“…Up to now, modulation approach was almost exclusively addressed by changing the depopulation rate of the activator emitting energy level, such as surface modification, Ln 3+ dopant concentration manipulation, plasmonic effect and introducing extra energy transfer channels 11a, 12. However, all these approaches usually bring along limitations including 1) a limited tuning range, and 2) UC efficiency reduction.…”

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confidence: 99%

Precisely Tailoring Upconversion Dynamics via Energy Migration in Core–Shell Nanostructures

et al. 2018

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Upconversion emission dynamics have long been believed to be determined by the activator and its interaction with neighboring sensitizers. Herein this assumption is, however, shown to be invalid for nanostructures. We demonstrate that excitation energy migration greatly affects upconversion emission dynamics. “Dopant ions’ spatial separation” nanostructures are designed as model systems and the intimate link between the random nature of energy migration and upconversion emission time behavior is unraveled by theoretical modelling and confirmed spectroscopically. Based on this new fundamental insight, we have successfully realized fine control of upconversion emission time behavior (either rise or decay process) by tuning the energy migration paths in various specifically designed nanostructures. This result is significant for applications of this type of materials in super resolution spectroscopy, high‐density data storage, anti‐counterfeiting, and biological imaging.

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confidence: 99%

Precisely Tailoring Upconversion Dynamics via Energy Migration in Core–Shell Nanostructures

et al. 2018

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“…Laser-generated rare-earth-doped materials such as Ca-a-SiAlON:Eu 2+ [65], YVO 4 :Eu 3+ [66,67], and Y 2 O 3 :Er,Yb [68][69][70][71] feature interesting optical properties which are a subject of current research. Among these, Y 2 O 3 :Er,Yb nanoparticles belong to the group of upconversion nanoparticles (UCNPs).…”

Section: Opticsmentioning

confidence: 99%

“…By changing the composition of the material, the upconversion efficiency and emission color can be tuned [68]. During upconversion, two or more photons are sequentially absorbed leading to the emission of light at a shorter wavelength than the excitation wavelength.…”

Section: Opticsmentioning

confidence: 99%

Process Chain for the Fabrication of Nanoparticle Polymer Composites by Laser Ablation Synthesis

2017

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Nanoparticle polymer composites are of growing interest due to their unique properties. However, conventional composite synthesis methods usually require several process steps including steps for cleaning and improving the particlematrix dispersion. As an alternative, laser ablation synthesis can be used to prepare tunable composite materials. This method enables an easy process chain, without the need of additional steps. In this status report, the process chain of laser-based pre-series fabrication of nanocomposites is visualized, and the increase of the method's technology readiness level is demonstrated. The process steps are demonstrated from the synthesis of the colloid to applicable functional products. The advantages of using laser ablation for nanocomposite synthesis are highlighted.

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“…Because of the fast exploration of UCNPs, several reviews have already summarized the preparation and applications of UCNPs 23, 37, 38, 39, 40, 41, 42, 43, 44, 45. In this review, we mainly focus on recent achievements on the usage of lanthanide‐doped UCNPs as efficient probes for biodetection since 2014.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems

2018

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Significant progress on upconversion‐nanoparticle (UCNP)‐based probes is witnessed in recent years. Compared with traditional fluorescent probes (e.g., organic dyes, metal complexes, or inorganic quantum dots), UCNPs have many advantages such as non‐autofluorescence, high chemical stability, large light‐penetration depth, long lifetime, and less damage to samples. This article focuses on recent achievements in the usage of lanthanide‐doped UCNPs as efficient probes for biodetection since 2014. The mechanisms of upconversion as well as the luminescence resonance energy transfer process is introduced first, followed by a detailed summary on the recent researches of UCNP‐based biodetections including the detection of inorganic ions, gas molecules, reactive oxygen species, and thiols and hydrogen sulfide.

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Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics

Cited by 2,299 publications

References 471 publications

Precisely Tailoring Upconversion Dynamics via Energy Migration in Core–Shell Nanostructures

Precisely Tailoring Upconversion Dynamics via Energy Migration in Core–Shell Nanostructures

Process Chain for the Fabrication of Nanoparticle Polymer Composites by Laser Ablation Synthesis

Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems

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