Upconversion nanoparticles modified with aminosilanes as carriers of DNA vaccine for foot-and-mouth disease

Guo, Huichen; Hao, Rongzeng; Qian, Haisheng; Sun, Shiqi; Sun, Dehui; Yin, Hong; Liu, Zaixin; Liu, Xiangtao

doi:10.1007/s00253-012-4042-z

Cited by 23 publications

(16 citation statements)

References 40 publications

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“…Other studies have also shown the delivery of DNA vaccines against foot and mouth disease virus [46]. The DNA was bound to amino-silane modified UCNs and was used for the delivery.…”

Section: Gene Therapymentioning

confidence: 99%

Luminescent Lanthanide Nanomaterials: An Emerging Tool for Theranostic Applications

Ranjan

Jayakumar

Zhang

2015

Nanomedicine (Lond.)

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Lanthanide materials have been gaining popularity for use in various theranostic applications, primarily due to their unique optical properties such as narrow emission bands, multiple emission wavelengths, emission tunability, long fluorescence lifetime and large Stokes shift. Apart from these, some lanthanide materials also exhibit magnetic and light-up conversion properties. Such nanomaterials have been used for a wide range of applications ranging from detection of biomarkers, in vitro and in vivo imaging to therapeutic applications. Recently, combined modalities of lanthanide nanomaterials for simultaneous detection/imaging and delivery of therapeutic agents (termed 'theranostics') have been explored. The various advantages and disadvantages of using lanthanide nanomaterials as theranostic agents and potential areas for future development have been discussed in this review.

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“…Other studies have also shown the delivery of DNA vaccines against foot and mouth disease virus [46]. The DNA was bound to amino-silane modified UCNs and was used for the delivery.…”

Section: Gene Therapymentioning

confidence: 99%

Luminescent Lanthanide Nanomaterials: An Emerging Tool for Theranostic Applications

Ranjan

Jayakumar

Zhang

2015

Nanomedicine (Lond.)

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“… 133 As revealed by in vitro studies, the transfection efficiency of the nanoparticles is comparable to lipofectamine, but with lower cytotoxicity. 133 Upon intramuscular injection of the UCNP/DNA complex to guinea pigs, induction of the humoral and cellular immune responses has been achieved. 133 The serum levels of anti-FMDV specific antibodies and neutralizing antibodies, as well as the proliferation of T-lymphocytes, have also been found to be enhanced.…”

Section: Recent Advances In Ucnp-based Gene Transfermentioning

confidence: 92%

“…As far as UCNP-based gene transfer is concerned, most of the efforts in the literature have been devoted to DNA delivery, whose practical potential in biomedicine has been evidenced in a pre-clinical trial, in which aminosilane-modified NaYF 4 :Yb,Er UCNPs have been exploited as carriers for DNA vaccination to combat foot-and-mouth disease (FMD). 133 The UCNPs can complex with the plasmid pcDNA3.1/VP1-GFP via electrostatic interactions, and protect the plasmid from DNase I degradation. 133 As revealed by in vitro studies, the transfection efficiency of the nanoparticles is comparable to lipofectamine, but with lower cytotoxicity.…”

Section: Recent Advances In Ucnp-based Gene Transfermentioning

confidence: 99%

“… 133 The UCNPs can complex with the plasmid pcDNA3.1/VP1-GFP via electrostatic interactions, and protect the plasmid from DNase I degradation. 133 As revealed by in vitro studies, the transfection efficiency of the nanoparticles is comparable to lipofectamine, but with lower cytotoxicity. 133 Upon intramuscular injection of the UCNP/DNA complex to guinea pigs, induction of the humoral and cellular immune responses has been achieved.…”

Section: Recent Advances In Ucnp-based Gene Transfermentioning

confidence: 99%

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Molecular design of upconversion nanoparticles for gene delivery

2017

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“…Up to now, most of the UCNPs drug delivery system were realized by coating PEG or mesoporous silica for probe attachment or drug loading [89][90][91][92]. Liu and coworkers functionalized UCNPs with a PEG grafted amphiphilic polymer.…”

Section: Ucnps For Cancer Therapymentioning

confidence: 99%

Up-Conversion Nanoparticles for Gastric Cancer Targeted Imaging and Therapy

Yang¹,

Han²,

Yue³

2016

Nano BioMed ENG

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As a new generation of fluorophores, up-conversion nanoparticles (UCNPs) exhibit high penetration depth in tissues, low photodamage to biological samples, large Stokes shifts, sharp emission bands, free auto-fluorescence background and high photostability, thus making them an ideal kind of fluorescent labels for a variety of assay formats ranging from bio-imaging to cancer therapy. In this article, the method for the synthesis of biocompatible UCNPs, the recent progress regarding the UCNPs for multimodal targeted tumor imaging, drug delivery, photodynamic therapy (PDT), and photothermal therapy (PTT) are discussed on emphasis. The challenges and opportunities in this emerging field are also presented.

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Upconversion nanoparticles modified with aminosilanes as carriers of DNA vaccine for foot-and-mouth disease

Cited by 23 publications

References 40 publications

Luminescent Lanthanide Nanomaterials: An Emerging Tool for Theranostic Applications

Luminescent Lanthanide Nanomaterials: An Emerging Tool for Theranostic Applications

Molecular design of upconversion nanoparticles for gene delivery

Up-Conversion Nanoparticles for Gastric Cancer Targeted Imaging and Therapy

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