Update DVO-Leitlinie 2017 „Prophylaxe, Diagnostik und Therapie der Osteoporose bei postmenopausalen Frauen und Männern“

Pfeil, Alexander; Lehmann, G.; Lange, U.

doi:10.1007/s00393-018-0549-8

Cited by 13 publications

(7 citation statements)

References 4 publications

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“…Participants were identified from a previous study evaluating coincidence and potential interference of osteoporosis and sarcopenia in a large, community-derived cohort of elderly men ( Genest et al, 2021 ). Out of 507 participants evaluated in that former study, 268 had risk factors warranting further assessment for osteoporosis according to applicable national guidelines and were therefore invited for a comprehensive musculoskeletal exam, including assessment of clinical risk factors for osteoporosis, DXA measurement and laboratory workup ( Pfeil et al, 2018 ; Neuerburg et al, 2017 ). Out of 113 who accepted that offer, 57 were willing to participate in this six months exercise intervention study.…”

Section: Methodsmentioning

confidence: 99%

Feasibility of simple exercise interventions for men with osteoporosis – A prospective randomized controlled pilot study

et al. 2021

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Background Aging is associated with progressive loss of musculoskeletal performance. Exercise interventions can improve physical function in the elderly but there is a paucity of comparative assessments in order to understand what specific goals can be achieved particularly with less demanding exercise interventions readily accessible for untrained men. Methods Prospective randomized, controlled, single center exploratory trial to compare four distinct exercise interventions, i.e. Resistance Training (RT), Whole Body Vibration Exercise (WBV), Qi Gong (QG) and wearing a Spinal orthosis (SO) for 6 months in men at risk for osteoporosis aged 65–90 years. Primary endpoint was change in isometric one repetition maximum force trunk strength for extension (TSE) and flexion (TSF) compared to baseline, secondary endpoints covered key parameters of geriatric functional assessment, including Handgrip Strength (HS), Chair-Rise-Test (CRT), Usual Gait Speed (UGS) and Timed-Up-and-Go (TUG). Results Altogether 47 men (mean age 77 ±6.1 years) were randomized to RT, ( n = 11) WBV ( n = 13), QG ( n = 10) and SO(n = 13). RT, defined as reference exercise intervention, lead to significant improvements for TSE ( p = 0.009) and TSF ( p = 0.013) and was significantly superior in the between-group analysis for TSE ( p = 0.038). Vibration exercise caused sign. Improvements in TSE ( p = 0.014) and CRT ( p = 0.005), the Spinal orthosis improved CRT ( p = 0.003) and Gait Speed ( p = 0.027), while the QG intervention did not attain any sig. Developments. Subgroup analyses revealed most pronounced musculoskeletal progress in vulnerable patients (age ≥ 80 years, pre-sarcopenia, multimorbidity ≥3chronic diseases). Irrespective of the type of exercise, participants ≥80 years experienced significant gains in TSE ( p = 0.029) and CRT ( p = 0.017). Presarcopenic subjects (Skeletal muscle Index (SMI) ≤10.75 kg/m 2 ) improved in TSE ( p = 0.003), CRT ( p = 0.001) and UGS ( p = 0.016). Multimorbid participants achieved sig. Gains in TSE ( p < 0.001), TSF ( p = 0.002), UGS ( p = 0.036) and HS ( p = 0.046). Conclusions In this exploratory trial we found that simple exercise interventions are feasible in elderly men eliciting specific benefits, i.e. improvements are attained in those tasks addressed with the respective exercise modality. While targeted resistance training is superior in increasing TSE, alterna...

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Section: Methodsmentioning

confidence: 99%

Feasibility of simple exercise interventions for men with osteoporosis – A prospective randomized controlled pilot study

et al. 2021

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“…Bei Nachweis pathologischer Werte soll neben einer GFD eine Vitamin D- und Kalziumsubstitution bzw. eine leitliniengerechte Therapie der Osteoporose erfolgen 284 .…”

Section: Kapitel 4: Therapieunclassified

“…Das Risiko für Hüftfrakturen war mit 1,69 (95 % KI 1,10-2,59) in der Metaanalyse aller prospektiven Studien erhöht [225,283]. Die DVO empfiehlt eine Basisdiagnostik bei allen Personen ab dem Alter von 50 Jahren bei Auftreten von Risikofaktoren, wobei die Zöliakie als Risikofaktor bewertet wird [284].…”

Section: Kommentarunclassified

Aktualisierte S2k-Leitlinie Zöliakie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)

et al. 2022

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Basophile-Aktivierungstest BDP Bundesverband Deutscher Pathologen e. V. CHOP-Regime Kombinationstherapie aus den 4 folgenden Medikamenten (C: Cyclophosphamid; H: Hydroxydaunorubicin aka Doxorubicin; Vincristin; P: Prednison, Prednisolon) CLE Konfokale Laserendomikroskopie CT Computertomografie DGAKI Deutsche Gesellschaft für Allergologie und Klinische Immunologie e. V. DGE Deutsche Gesellschaft für Ernährung e. V. DGEM Deutsche Gesellschaft für Ernährungsmedizin e. V. DGIM Deutsche Gesellschaft für Innere Medizin e. V. DGKJ Deutsche Gesellschaft für Kinder-und Jugendmedizin e. V. DGI Deutsche Gesellschaft für Immungenetik DGP Deutsche Gesellschaft für Pathologie e. V. dGP-IgA deaminierte Gliadinpeptid-IgA-Antikörper dGP-IgG deaminierte Gliadinpeptid-IgG-Antikörper EATL Enteropathie-assoziiertes T-Zelllymphom

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“…of vitamin D. The dosage of vitamin D should be increased during concurrent therapy with glucocorticoids [48]. When choosing the dosage, a risk-benefit assessment is recommended, such as kidney stones, kidney disease, heart disease, gastrointestinal disease [49].…”

Section: Non-pharmacological Treatment Interventionsmentioning

confidence: 99%

“…For men, alendronate, teriparatide, zoledronate, and denosumab have received approval, see ▶Tab. 4 [5,19,32,[49][50][51]. Comparative studies are available for some of these agents.…”

Section: Pharmacologic Treatment Interventionsmentioning

confidence: 99%

Osteoporosis and Rheumatoid Arthritis-Diagnosis, Diagnostics and Therapy

Buehring

Thomasius²,

Schultz

et al. 2021

Osteologie

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Many inflammatory rheumatic diseases are associated with an increased fracture risk. Causes include the pro-inflammatory cytokines which are elevated in these diseases, reduced mobility and physical activity often caused by joint pain, and medications that negatively affect bone quality. Osteoporosis, the loss of bone mass and structure is the result. This review article summarizes the current diagnostic and therapeutic osteoporosis recommendations for patients with rheumatoid arthritis. It should be emphasized that early measures for the detection and treatment of osteoporosis are particularly important, since the risk factor constellation often present in this patient population leads to a relatively high imminent fracture risk at the beginning of the disease and the start of glucocorticoid therapy. Treatment initiations as early as possible with effective control of inflammatory activity is therefore essential to reduce the risk of osteoporosis. The administration of glucocorticoids should be reduced as far as the clinical context allows. Fracture risk should be assessed when the RA diagnosis is made and in regular intervals thereafter. Osteoporosis medication should be initiated based on the overall fracture risk. The choice of medication is based on the particular risk and indication. The basis of therapy is an adequate intake of vitamin D and calcium and adapted physical activity

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Update DVO-Leitlinie 2017 „Prophylaxe, Diagnostik und Therapie der Osteoporose bei postmenopausalen Frauen und Männern“

Cited by 13 publications

References 4 publications

Feasibility of simple exercise interventions for men with osteoporosis – A prospective randomized controlled pilot study

Feasibility of simple exercise interventions for men with osteoporosis – A prospective randomized controlled pilot study

Aktualisierte S2k-Leitlinie Zöliakie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)

Osteoporosis and Rheumatoid Arthritis-Diagnosis, Diagnostics and Therapy

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