Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours

Vered, Marilena; Wright, John M.

doi:10.1007/s12105-021-01404-7

Cited by 189 publications

(152 citation statements)

References 53 publications

Supporting

Mentioning

130

Contrasting

Unclassified

Order By: Relevance

“…According to this, CEOTs are classified as benign epithelial odontogenic tumors. 4 The tumor is supposed to arise from dental lamina remnants, from the reduced epithelium or intermediate layer of the enamel organ, or even from the oral epithelium, however, the etiopathogenesis of CEOT is still doubtful.…”

Section: Discussionmentioning

confidence: 99%

Clinical, Radiological features of Calcifying Epithelial Odontogenic Tumor: Report of two rare cases

et al. 2022

View full text Add to dashboard Cite

The calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic tumor constitutes around 1% of all odontogenic tumours involving the jaw. The intraosseous and extraosseous variant constitutes about 95% and 5% of CEOT respectively. We have reported two CEOT cases. One is associated with an impacted left third molar in the maxilla of 39-year-old female patient, and the other with a sessile soft tissue gingival mass in the left molar region of a 30-year-old female patient. It also emphasizes the importance of advanced imaging and peculiar ﬁndings of computed tomography in diagnosing this rare tumour. The visualization of the internal structure of the lesion and the involvement of the neighbouring structures were considered very helpful for diagnosis and treatment planning. Early detection and treatment planning for such rare cases is required to prevent further complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical, Radiological features of Calcifying Epithelial Odontogenic Tumor: Report of two rare cases

et al. 2022

View full text Add to dashboard Cite

show abstract

“…However, several studies have discussed the clinical and pathological differences between OOC and OKC [ 2 – 9 ]. The new edition of the World Health Organization classification of head and neck tumors published in 2022 has described OOC as a distinct entity from OKC [ 1 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, OOC recurs less frequently, in comparison to OKC, which has recurrence rate as high as 2.5–62% [ 1 , 9 , 11 ]. In addition, OKC is genetically associated with mutations in the protein patched homolog 1 ( PTCH1 ) gene, which activates the Sonic hedgehog (SHH) signaling pathway and results in aberrant cell proliferation of the OKC epithelium [ 1 , 10 , 11 ]. The PTCH1 mutation was detected in up to 93% of sporadic OKCs [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, OKC is genetically associated with mutations in the protein patched homolog 1 ( PTCH1 ) gene, which activates the Sonic hedgehog (SHH) signaling pathway and results in aberrant cell proliferation of the OKC epithelium [ 1 , 10 , 11 ]. The PTCH1 mutation was detected in up to 93% of sporadic OKCs [ 10 ]. In addition, 5% of all OKCs occur as part of nevoid basal cell carcinoma syndrome (NBCCS) caused by PTCH1 mutation [ 1 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Multiple orthokeratinized odontogenic cysts: clinical, pathological, and genetic characteristics

et al. 2022

View full text Add to dashboard Cite

Background: Orthokeratinized odontogenic cyst (OOC) is a rare developmental odontogenic cyst of the jaw. It was originally believed to be a variant of odontogenic keratocyst (OKC) but is now considered to be a distinct entity. OOC usually presents as a single lesion and recurs infrequently. On the other hand, OKC often presents with multiple lesions and displays locally aggressive behavior and a high recurrence rate associated with the protein patched homolog 1 (PTCH1) gene mutation. Multiple OOC cases are extremely rare and seem to be aggressive, but their pathogenesis is not fully understood. This study aimed to determine the clinical, pathological, and genetic characteristics of multiple OCC. Methods: Three cases of multiple OOC were evaluated for clinical and histological findings, and immunohistochemical expression of Ki-67 and Bcl-2. Furthermore, PTCH1 mutations were analyzed by next-generation sequencing using a custom panel to cover the entire exon of PTCH1. Results: The three cases of multiple OOC included two men and one woman with a mean age of 25.3 years old (range, 18–38 years old). Each case had two or three OOCs (total of seven OOCs), all of which were simultaneously detected. Of the seven OOCs that manifested as multiple jaw cysts, seven (100%) occurred in the posterior regions, four (57.1%) occurred in the mandible, and four (57.1%) were associated with an impacted tooth. Histological examination revealed cysts lined by orthokeratinized stratified squamous epithelium. Immunohistochemistry showed a low Ki-67 labeling index and no Bcl-2 expression in the seven OOCs. No pathogenic PTCH1 mutations were detected in any of the seven OOCs. None of the patients had any other symptoms or signs of recurrence at the last follow-up (6–60 months). Conclusion: Multiple OOCs appeared to occur more often in younger patients than solitary OOC. Both multiple and solitary OOCs may be related diseases within the entity of odontogenic cysts. Multiple OOCs are clinicopathologically and genetically distinct from OKC.

show abstract

“…Traditionally, the PDL, which is part of the odontogenic apparatus, has been proposed as the histogenetic source of central COsF based primarily on clinical observations of its confinement to tooth-bearing areas. [2][3][4][5] Nevertheless, one should bear in mind that radiological or pathological evidence to support this hypothesis has so far been unavailable in the existing literature, 2 as COsFs typically occur as sizable intraosseous lesions. Here, we provide conclusive evidence of a PDL origin for central COsF by presenting a unique exophytic-type lesion that developed on the lateral surface of the tooth root.…”

mentioning

confidence: 99%

Direct evidence supporting a periodontal ligament origin for central cemento‐ossifying fibroma

Ide

Sakamoto

Miyazaki

et al. 2022

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours

Cited by 189 publications

References 53 publications

Clinical, Radiological features of Calcifying Epithelial Odontogenic Tumor: Report of two rare cases

Clinical, Radiological features of Calcifying Epithelial Odontogenic Tumor: Report of two rare cases

Multiple orthokeratinized odontogenic cysts: clinical, pathological, and genetic characteristics

Direct evidence supporting a periodontal ligament origin for central cemento‐ossifying fibroma

Contact Info

Product

Resources

About