Update in Tuberculosis/Pulmonary Infections 2015

Koenig, Serena P.; Furin, Jennifer

doi:10.1164/rccm.201601-0129up

Cited by 14 publications

(12 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An important next step is to compare expression signatures at the respective sites of disease to identify common pathways that can underpin dissection of the fundamental pathological process. This approach may elucidate the disease mechanisms in pulmonary TB, which continues to be poorly understood and for which standard treatment has remained unchanged for 40 years and vaccination for almost 100 years (9). Defining an autoimmune process that exacerbates pathology in TB would help inform emerging host-directed therapies, to limit the lung-tissue destruction that results in mortality and potentially to accelerate cure (10), as well as avoid vaccination strategies that may inadvertently exacerbate lung destruction and transmission.…”

Section: To the Editormentioning

confidence: 99%

Gene Expression Signatures in Tuberculosis Have Greater Overlap with Autoimmune Diseases Than with Infectious Diseases

Clayton

Polak

Woelk

et al. 2017

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Section: To the Editormentioning

confidence: 99%

Gene Expression Signatures in Tuberculosis Have Greater Overlap with Autoimmune Diseases Than with Infectious Diseases

Clayton

Polak

Woelk

et al. 2017

Am J Respir Crit Care Med

View full text Add to dashboard Cite

“…Determining the diagnostic treatment for TB was also significantly difficult because conventional therapies were ineffective for drug-resistant MTB or non-tuberculous mycobacteria [ 14 ]. A culture from the vocal cord tissue might assist in the diagnosis despite the prior low success rate.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterial identification on homogenised biopsy facilitates the early diagnosis and treatment of laryngeal tuberculosis

Gan

et al. 2020

Open Medicine

View full text Add to dashboard Cite

AbstractIntroductionThe incidence of laryngeal tuberculosis has increased gradually in recent years. Laryngeal tuberculosis has strong infectivity and atypical clinical manifestations. Hence, establishing the early diagnosis of laryngeal tuberculosis is considered difficult, resulting in the high rate of misdiagnosis of laryngeal tuberculosis and increased rates of tuberculosis infection.ObjectiveThis study aimed to describe a case of laryngeal tuberculosis detected using the mycobacteria gene chips technology, facilitating the early diagnosis and the treatment of laryngeal tuberculosis.Case presentationA 27-year-old woman presented with a 7-day history of hoarseness, with a normal routine blood chemistry test and chest computed tomography results. Histological analysis of the vocal cord biopsy showed granulomatous inflammation and the negative acid-fast stain test. The mycobacteria gene chips method was used to directly examine the vocal cord tissue treated with homogenate, and the Mycobacterium tuberculosis was successfully identified. Thus, the early diagnosis of laryngeal tuberculosis and the drug sensitivity of rifampin and isoniazid were confirmed. The patient recovered after undergoing a 1-year standard anti-tuberculosis therapy.ConclusionsMycobacterial identification on homogenised biopsy using the mycobacteria gene chips method significantly facilitates the early diagnosis and the treatment of tuberculosis.

show abstract

“…TB paru stadium lanjut banyak timbul daerah fibrosis di seluruh paru, sehingga mengurangi jumlah total jaringan paru fungsional. Keadaan ini menyebabkan peningkatan kerja pada bagian otot pernapasan yang berfungsi untuk ventilasi paru dan berkurangnya kapasitas vital dan kapasitas pernapasan, berkurangnya luas membran pernapasan dan peningkatan ketebalan membran pernapasan yang menyebabkan kapasitas difusi paru secara progresif, dan kelainan rasio ventilasi-perfusi dalam paru, sehingga mengurangi difusi oksigen dan karbondioksida paru secara keseluruhan (Koenig & Furin, 2016).…”

Section: Pendahuluanunclassified

“…Diharapkan dengan melakukan latihan pernafasan dapat memperbaiki kapasits fungsi paru dan menurunkan resiko terjadinya perubahan bentuk fisik pada penderita TB paru. Dukungan sosial yang bermakna dengan keluarga atau teman atau petugas kesehatan terbukti memperbaiki hasil akhir kesehatan dan kesejahteraan pada individu (Koenig & Furin, 2016). Peran kader TB dan keluarga diharapkan tidak pada aspek farmakologis saja, tetapi juga upaya non farmakologis salah satunya melalui latihan pernapasan.…”

Section: Pendahuluanunclassified

Pemberdayaan Kader Dan Keluarga Dalam Upaya Perbaikan Perubahan Fisik Penderita Tuberculosis Melalui Latihan Pernapasan

Pratiwi

Nimah

Dewi

2020

Abi

View full text Add to dashboard Cite

Penderita tuberculosis paru (TB) mengalami penurunan fungsi paru sehingga compliance paru berkurang yang beresiko tinggi terjadinya perubahan bentuk fisik. Selama ini intervensi yang dilakukan kepada penderita tuberculosis paru masih terpusat pada penanganan farmakologis. Peran kader TB dan keluarga diharapkan tidak pada aspek farmakologis saja, tetapi juga upaya non farmakologis salah satunya melalui latihan pernapasan. Diharapkan dengan melakukan latihan pernapasan dapat memperbaiki kapasitas fungsi paru dan menurunkan resiko perubahan bentuk fisik pada penderita TB paru. Wilayah Kerja Puskesmas yang akan menjadi tempat pengabdian masyarakat ini adalah Puskesmas Tanah Kali Kedinding dan Puskesmas kenjeran Surabaya. Metode yang digunakan melalui pendidikan dengan media booklet dan praktik latihan pernapasan sebagai Upaya Perbaikan Perubahan Fisik Pada Penderita Tuberkulosis Paru Di Surabaya kepada Kader TB dan keluarga penderita TB. Evaluasi Akhir Program Pengabdian Kepada Masyarakat membandingkan nilai pre-test dan post-test pada kuesioner pengetahuan dan sikap kepada khalayak sasaran. Hasil pengabdian masyarakat, terdapat 61 orang kader TB dan keluarga dengan rata-rata usia 35 tahun yang berpatisipasi pada kegiatan ini dimana hasil pengukuran terhadap tingkat pengetahuan p=0,30 (p<0,05) dan kuesioner terkait kondisi pernapasan dengan p=0,01 (p<0,05) sehingga terdapat perbedaan yang bermakna antara sebelum dan sesudah diberikan pendidikan dan pelatihan latihan pernapasan. Kesimpulan: pemberdayaan kader dan keluarga melalui pendidikan dan praktik latihan pernapasan dapat dijadikan upaya memperbaiki kapasitas fungsi paru dan menurunkan resiko terjadinya perubahan bentuk fisik pada penderita TB paru melalui transfer pengetahuan dan pengawasan dalam praktik latihan pernapasan bagi penderita TB yang dilakukan oleh kader dan keluarga penderita TB.

show abstract

Update in Tuberculosis/Pulmonary Infections 2015

Cited by 14 publications

References 26 publications

Gene Expression Signatures in Tuberculosis Have Greater Overlap with Autoimmune Diseases Than with Infectious Diseases

Gene Expression Signatures in Tuberculosis Have Greater Overlap with Autoimmune Diseases Than with Infectious Diseases

Mycobacterial identification on homogenised biopsy facilitates the early diagnosis and treatment of laryngeal tuberculosis

Pemberdayaan Kader Dan Keluarga Dalam Upaya Perbaikan Perubahan Fisik Penderita Tuberculosis Melalui Latihan Pernapasan

Contact Info

Product

Resources

About