Update of a cohort mortality study of workers exposed to methylene chloride employed at a plant producing cellulose triacetate film base

Tomenson, John Andrew

doi:10.1007/s00420-011-0621-z

Cited by 10 publications

(2 citation statements)

References 21 publications

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“…Other than the above study 1) , no cancer epidemiological study or cancer case report of 1,2-DCP exposed workers has been published. There have been four cohort studies of DCM exposed workers in two cellulose triacetate-film production plants 3,4) and two cellulose triacetate-fiber production plants 5,6) , but of these, only Lane's original study found a significantly increased mortality risk for biliary tract cancer 7) . Consequently, the association between these chemicals and cholangiocarcinoma should be studied further.…”

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confidence: 99%

Two Offset Printing Workers with Cholangiocarcinoma

Kumagai

2014

Journal of Occupational Health

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Two Offset Printing Workers with Cholangiocarcinoma

Kumagai

2014

Journal of Occupational Health

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“…26 Among the epidemiological studies published since the Research Recommendations, there was an extended analysis of a cohort mortality study of workers in cellulose triacetate fiber and film facilities in England, with quantitative measures of DCM from area samples. 60 There were few cancer deaths and no clear findings according to categories of cumulative exposure. There were also other acetone and methanol exposures.…”

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confidence: 97%

Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned

Turner,

Cogliano,

Guyton

et al. 2023

Environ Health Perspect

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Background: The International Agency for Research on Cancer (IARC) Monographs program assembles expert working groups who publish a critical review and evaluation of data on agents of interest. These comprehensive reviews provide a unique opportunity to identify research needs to address classification uncertainties. A multidisciplinary expert review and workshop held in 2009 identified research gaps and needs for 20 priority occupational chemicals, metals, dusts, and physical agents, with the goal of stimulating advances in epidemiological studies of cancer and carcinogen mechanisms. Overarching issues were also described. Objectives: In this commentary we review the current status of the evidence for the 20 priority agents identified in 2009. We examine whether identified Research Recommendations for each agent were addressed and their potential impact on resolving classification uncertainties. Methods: We reviewed the IARC classifications of each of the 20 priority agents and identified major new epidemiological and human mechanistic studies published since the last evaluation. Information sources were either the published Monograph for agents that have been reevaluated or, for agents not yet reevaluated, Advisory Group reports and literature searches. Findings are described in view of recent methodological developments in Monographs evidence evaluation processes. Discussion: The majority of the 20 priority agents were reevaluated by IARC since 2009. The overall carcinogen classifications of 9 agents advanced, and new cancer sites with either “sufficient” or “limited” evidence of carcinogenicity were also identified for 9 agents. Examination of published findings revealed whether evidence gaps and Research Recommendations have been addressed and highlighted remaining uncertainties. During the past decade, new research addressed a range of the 2009 recommendations and supported updated classifications for priority agents. This supports future efforts to systematically apply findings of Monograph reviews to identify research gaps and priorities relevant to evaluation criteria established in the updated IARC Monograph Preamble. https://doi.org/10.1289/EHP12547

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Dichlormethan [MAK Value Documentation in German Language, 2015]

2015

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 59. Lieferung, Ausgabe 2015 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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Update of a cohort mortality study of workers exposed to methylene chloride employed at a plant producing cellulose triacetate film base

Abstract: The study provided no indication that employment at the plant, or exposure to methylene chloride, had adversely affected the mortalities of workers.

Cited by 10 publications

References 21 publications

Two Offset Printing Workers with Cholangiocarcinoma

Two Offset Printing Workers with Cholangiocarcinoma

Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned

Dichlormethan [MAK Value Documentation in German Language, 2015]

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