Update of Immunosenescence in Cerebral Small Vessel Disease

Jian, Banghao; Hu, Mengyan; Cai, Wei; Zhang, Bingjun; Lu, Zhengqi

doi:10.3389/fimmu.2020.585655

Cited by 18 publications

(11 citation statements)

References 125 publications

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“…Indeed, the majority of cSVD cases are sporadic and associated with diverse risk factors, as such, it is critically important to develop animal models that replicate some of the pathological features associated with VaD. However, the overwhelming findings indicate the loss-of-function on the local cerebrovascular network caused a central role in initiating a pathological cascade of events that lead to altered neuro-glial functions, and thus subsequently dementia (Rouhl et al, 2012;Shoamanesh et al, 2015;Fu and Yan, 2018;Li et al, 2018;Jian et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors

Lecordier

Manrique-Castano

Moghrabi

et al. 2021

Front. Aging Neurosci.

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Vascular dementia (VaD) constitutes the second most prevalent cause of dementia in the world after Alzheimer’s disease (AD). VaD regroups heterogeneous neurological conditions in which the decline of cognitive functions, including executive functions, is associated with structural and functional alterations in the cerebral vasculature. Among these cerebrovascular disorders, major stroke, and cerebral small vessel disease (cSVD) constitute the major risk factors for VaD. These conditions alter neurovascular functions leading to blood-brain barrier (BBB) deregulation, neurovascular coupling dysfunction, and inflammation. Accumulation of neurovascular impairments over time underlies the cognitive function decline associated with VaD. Furthermore, several vascular risk factors, such as hypertension, obesity, and diabetes have been shown to exacerbate neurovascular impairments and thus increase VaD prevalence. Importantly, air pollution constitutes an underestimated risk factor that triggers vascular dysfunction via inflammation and oxidative stress. The review summarizes the current knowledge related to the pathological mechanisms linking neurovascular impairments associated with stroke, cSVD, and vascular risk factors with a particular emphasis on air pollution, to VaD etiology and progression. Furthermore, the review discusses the major challenges to fully elucidate the pathobiology of VaD, as well as research directions to outline new therapeutic interventions.

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Section: Discussionmentioning

confidence: 99%

Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors

Lecordier

Manrique-Castano

Moghrabi

et al. 2021

Front. Aging Neurosci.

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“…In hereditary CSVD, specific enzyme replacement therapy for febrile disease has been proven to be effective, and the main drug is exogenous gene recombinant α-galactosidase A, including arga-β and arga-α. The potential therapeutic targets of CSVD are as follows: ① immune aging may be related to the occurrence of age-related CSVD; ② reducing the immune inflammatory response may delay the progression of age-related CSVD ( 101 ); ③ vitamin B supplementation may delay WMH progression in patients with severe CSVD ( 102 ). Controlling the risk factors of cerebrovascular diseases, such as hypertension, diabetes, heart disease, hyperlipidemia, obesity, and smoking, can significantly reduce the mortality and disability rates of patients with CSVD.…”

Section: Treatmentmentioning

confidence: 99%

Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment

et al. 2022

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Cerebral small vessel disease (CSVD) is the most common chronic vascular disease involving the whole brain. Great progress has been made in clinical imaging, pathological mechanism, and treatment of CSVD, but many problems remain. Clarifying the current research dilemmas and future development direction of CSVD can provide new ideas for both basic and clinical research. In this review, the risk factors, biological markers, pathological mechanisms, and the treatment of CSVD will be systematically illustrated to provide the current research status of CSVD. The future development direction of CSVD will be elucidated by summarizing the research difficulties.

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“…Addressing the immune response of injured brain endothelium and the BBB may be a promising therapeutic strategy (Cai et al 2021). Ongoing interactions between the gut microbiota and the host immune system have important implications for the induction, functional modulation, or suppression of local and systemic immune responses (Jian et al 2020). The field of drug intervention of intestinal flora in the treatment of cerebral small vessel disease is almost blank, and it is also one of the main research trends in the future.…”

Section: Study On Drug Intervention Of Intestinal Flora In the Treatm...mentioning

confidence: 99%

Cerebral Small Vessel Disease: A Bibliometric Analysis

Yang

Xie

et al. 2022

J Mol Neurosci

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Cerebral small vessel disease is a common neurological disease, and its incidence is increasing year by year worldwide. In recent years, research on cerebral small vessel disease has gained more and more attention. Our research aims to visualize publications to identify the hotspots and frontiers of cerebral small vessel disease research, and to provide reference and guidance for further research. Publications related to cerebral small vessel disease were searched from the Web of Science Core Collection and screened according to inclusion criteria. CiteSpace 5.8.R3 was used to evaluate and visualize results, including generating web maps and analyzing annual publications, countries, institutions, bibliographic and co-cited references, and keywords; in this article, we use CiteSpace and VOSviewer for the 2012 Cerebral small vessel disease and bibliometric analysis from January 1, 2022 to April 30, 2022. A total of 3037 papers related to cerebral small vessel disease were retrieved, and the number of published papers showed a steady upward trend. Among them, Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration, the most symbolic references in the field of cerebral small vessel disease have been cited a total of 438 times. Stroke is the most active journal (227 articles) and USA publishes up to 800 articles. Harvard Med SchUniv Edinburgh (133 papers) and Charidimou (85 papers) are the institutions and authors who have made the most contributions in this field, respectively. Among the keywords, most of them are related to the pathogenesis of cerebral small vessel disease. After 2018, gut-brain axis and cortex are the keywords with the strongest number of cited outbreaks. There is increasing evidence that cerebral small vessel disease is a research frontier and may remain a research hotspot in the future.

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Update of Immunosenescence in Cerebral Small Vessel Disease

Cited by 18 publications

References 125 publications

Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors

Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors

Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment

Cerebral Small Vessel Disease: A Bibliometric Analysis

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