Update on granulosa cell tumours of the ovary

Stuart, Gavin; Dawson, Lesa

doi:10.1097/00001703-200302000-00005

Cited by 68 publications

(58 citation statements)

References 15 publications

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“…Staging procedures are the same and a laparotomy should be performed trough a midline incision [1,2]. In fact it is still the general agreement that a patient with ovarian cancer should have laparotomy to ensure optimal staging and treatment.…”

Section: Discussionmentioning

confidence: 99%

“…GCT typically presents at an early stage. Patients may have symptoms of hyper-estrogenism associated with a pelvic mass, but diagnosis is rare before surgery [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Usually, staging and restaging are performed by laparotomy, while the role of laparoscopy is not yet clear [2]. In the last two decades, laparoscopic surgery has greatly changed the approach to ovarian masses, and most of them are treated laparoscopically.…”

Section: Introductionmentioning

confidence: 99%

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Laparoscopic restaging of ovarian granulosa cells tumor: three cases report

et al. 2008

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Granulosa cell tumor (GCT) of the ovary is an uncommon neoplasm, often diagnosed at an early stage. Surgery is necessary for definitive diagnosis and staging. Complete staging is recommended as for epithelial ovarian cancer and a restaging procedure is sometime required. The staging procedure should include evaluation of para-aortic and pelvic lymph nodes. We report three cases of laparoscopic restaging of GCT. The patients were treated in our Institution from August 2005 to January 2007. They were diagnosed an ovarian cyst and underwent laparoscopic adnexectomy. Histology showed a GCT (one case of juvenile type in a 38-year-old woman). All the patients were submitted to laparoscopic restaging with pelvic and para-aortic lymphadenectomy. Mean operation time was 195 min. A mean number of 32 lymph nodes were removed. No major intraoperative or postoperative complication occurred. Patients were discharged on the second or third postoperative day. All the patients are well and without disease. Laparoscopic restaging of GCT is feasible and allows para-aortic and pelvic lymphadenectomy. Patients restaged by laparoscopy benefit of a less invasive treatment.

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Section: Discussionmentioning

confidence: 99%

“…GCT typically presents at an early stage. Patients may have symptoms of hyper-estrogenism associated with a pelvic mass, but diagnosis is rare before surgery [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Laparoscopic restaging of ovarian granulosa cells tumor: three cases report

et al. 2008

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“…Sur le plan biologique, les taux sé riques et urinaires d'estradiol sont gé né ralement augmenté s ; par ailleurs, les taux plasmatiques des gonadotrophines (FSH et LH) sont diminué s [1,7,12]. Dans les formes virilisantes, les taux des cé tosté roï-des urinaires, de testosté rone et de la delta-4-androstè nedione sont gé né ralement é levé s [7].…”

Section: Discussionunclassified

Tumeur à cellules de la granulosa juvénile de l’ovaire: à propos de deux cas

Kallel¹,

Makni²,

Ellouze³

et al. 2008

Oncologie

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“…El crecimiento es lento y las metástasis a distancia son raras, aunque están descritas a nivel pulmonar (4,5), óseo (6), peritoneal y hepático (7). Pueden presentar recurrencias tardías, incluso 25 años después del tratamiento por lo que precisan seguimiento indefinido (8).…”

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Shock hipovolémico como forma de presentación de un tumor ovárico

Rodríguez

Alonso

Sánchez

et al. 2005

An. Med. Interna (Madrid)

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El efecto de radioyodo en el tiroides es producir una intensa tiroiditis por radiación seguida por una progresiva fibrosis intersticial y atrofia glandular (1). Para determinar la dosis de I-131 en la EG, se han aplicado distintas técnicas para calcular la dosis, mediante tamaño glandular, captación de yodo y turnover de yodo. Sin embargo diversos estudios de seguimiento en pacientes con EG tratados con radioyodo, utilizando distintos métodos de cálculo de dosis, no han encontrado ninguna ventaja sobre utilizar dosis fijas o dosis ajustadas (5). Conseguir que el paciente permanezca eutiroideo, sería el objetivo deseable. Sin embargo la mayoría de los pacientes desarrollan hipotiroidismo permanente. La incidencia del mismo en la EG es de 103/1000 personas-año mientras que en pacientes con adenoma tóxico y bocio multinodular tratados con radioyodo es de 17-18/1000 (6), en nuestro medio la presencia de hipotiroidismo post I-131 en pacientes con EG es del 82,4% algo inferior al descrito por Herrera y cols que es del 90% (2).

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Update on granulosa cell tumours of the ovary

Abstract: The pathology and treatment of women with granulosa cell tumours of the ovary is complex. Such women should be managed in a multidisciplinary gynaecological oncology unit. A better understanding of the molecular pathology may assist treatment.

Cited by 68 publications

References 15 publications

Laparoscopic restaging of ovarian granulosa cells tumor: three cases report

Laparoscopic restaging of ovarian granulosa cells tumor: three cases report

Tumeur à cellules de la granulosa juvénile de l’ovaire: à propos de deux cas

Shock hipovolémico como forma de presentación de un tumor ovárico

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