Update on Photodermatoses

Santoro, Frank; Lim, Henry W.

doi:10.1016/j.sder.2011.07.007

Cited by 31 publications

(15 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been suggested that the formation of ROS in cells after treatment with aminoglycosides may play an important role in their toxicity . The overproduction of ROS may cause damage in DNA, proteins, and lipids, which may cause cell dysfunction or death . It has been stated that the presence of aminoglycosides in hair cells of the inner ear is correlated with increased oxidative stress .…”

Section: Discussionmentioning

confidence: 99%

Kanamycin induces free radicals formation in melanocytes: An important factor for aminoglycosides ototoxicity

Wrześniok

Rok

Beberok

et al. 2018

J of Cellular Biochemistry

View full text Add to dashboard Cite

Ototoxicity is well‐documented but not fully understood undesirable side effect of aminoglycoside antibiotic, kanamycin. Kanamycin is capable of binding to melanin biopolymers—natural pigments of the skin, hair, and eyes. Melanin‐producing cells, melanocytes, are also present in the inner ear and are known to be necessary for normal hearing. It was considered that melanin content in the inner ear may influence aminoglycoside‐induced ototoxic effect. The impact of kanamycin on melanocytes homeostasis may thus play role in the antibiotic‐induced ototoxic effect. Previously, we demonstrated that kanamycin disturbs homeostasis in light‐pigmented melanocytes. To investigate if/how melanization contributes to this phenomenon, the study using in vitro model of dark‐pigmented melanocytes is required. Spectrophotometric measurements and electron paramagnetic resonance (EPR) spectroscopy analysis were performed. Kanamycin induced a concentration‐dependent loss in HEMn‐DP melanocytes viability. The value of IC 50 was estimated to be 5.0 mM. Modulation of the activity of analyzed antioxidant enzymes and increased production of free radicals as well as the decrease of the melanin content were observed. Our results confirmed that kanamycin generates oxidative stress in melanocytes. The increased level of free radicals caused by kanamycin may be responsible for the imbalance of antioxidant defense and the reduction of melanin content in melanocytes. The role of melanin in the mechanism of kanamycin‐induced hearing impairment was discussed and the obtained results were compared with the previously demonstrated data concerning light‐pigmented melanocytes.

show abstract

Section: Discussionmentioning

confidence: 99%

Kanamycin induces free radicals formation in melanocytes: An important factor for aminoglycosides ototoxicity

Wrześniok

Rok

Beberok

et al. 2018

J of Cellular Biochemistry

View full text Add to dashboard Cite

show abstract

“…When these excited state molecules return to their ground state, they transfer energy to surrounding oxygen, thereby inducing the generation of reactive oxygen species. The ROS cause cellular damage through the oxidation of lipids, nucleic acids and proteins [27,38]. ROS may react with both cellular and extracellular components, leading to induction of cytotoxicity, apoptosis, mutations and carcinogenesis [35].…”

Section: Discussionmentioning

confidence: 99%

Effect of tetracycline and UV radiation on melanization and antioxidant status of melanocytes

Rok

Buszman

Delijewski

et al. 2015

Journal of Photochemistry and Photobiology B: Biology

View full text Add to dashboard Cite

“…166 CEP or Gunther disease is a rare autosomal recessive disorder, in which the defective enzyme is uroporphyrinogen III synthase, which leads to an accumulation uroporphyrinogen I and III in the bone marrow, blood, and other organs. 167 Patients have erythema, stinging, and photosensitivity, which lead to the formation of bullae within a day or 2 of exposure to the sun. Ulcerations and mutilating scarring of the ears, eyes, and nose can occur.…”

Section: Porphyriasmentioning

confidence: 99%

Cutaneous Deposits

Molina-Ruiz

Cerroni

Kutzner

et al. 2014

The American Journal of Dermatopathology

View full text Add to dashboard Cite

: The cutaneous deposition disorders are a group of unrelated conditions characterized by the accumulation of either endogenous or exogenous substances within the skin. These cutaneous deposits are substances that are not normal constituents of the skin and are laid down usually in the dermis, but also in the subcutis, in a variety of different circumstances. There are 5 broad categories of cutaneous deposits. The first group includes calcium salts, bone, and cartilage. The second category includes the hyaline deposits that may be seen in the dermis in several metabolic disorders, such as amyloidosis, gout, porphyria, and lipoid proteinosis. The third category includes various pigments, heavy metals, and complex drug pigments. The fourth category, cutaneous implants, includes substances that are inserted into the skin for cosmetic purposes. The fifth category includes miscellaneous substances, such as oxalate crystals and fiberglass. In this article, the authors review the clinicopathologic characteristics of cutaneous deposition diseases, classify the different types of cutaneous deposits, and identify all the histopathologic features that may assist in diagnosing the origin of a cutaneous deposit.

show abstract

Update on Photodermatoses

Cited by 31 publications

References 39 publications

Kanamycin induces free radicals formation in melanocytes: An important factor for aminoglycosides ototoxicity

Kanamycin induces free radicals formation in melanocytes: An important factor for aminoglycosides ototoxicity

Effect of tetracycline and UV radiation on melanization and antioxidant status of melanocytes

Cutaneous Deposits

Contact Info

Product

Resources

About