Update on the Diagnosis and Prognosis of Preeclampsia with the Aid of the sFlt-1/ PlGF Ratio in Singleton Pregnancies

Herraı̀z, Ignacio; Llurba, Elisa; Verlohren, Stefan; Galindo, Alberto

doi:10.1159/000477903

Cited by 122 publications

(94 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hypertensive disorders and pre-eclampsia have been reported to be associated with FGR. The pathogenesis of dysfunctional placental implantation in pre-eclampsia is hypothesised to lead to decreased uteroplacental flow and placental ischaemia, decreasing oxygen and nutritional supply to the fetus 18,19 . In our study, the incidence of hypertensive disorders or pre-eclampsia was 4.5%, which was comparable to the 5.2% reported in a large retrospective study of 112 386 Chinese women 20 .…”

Section: Discussionmentioning

confidence: 99%

Risk factors and pregnancy outcomes of term fetal growth restriction

2019

Hong Kong J Gynaecol Obstet Midwifery

View full text Add to dashboard Cite

To evaluate the maternal risk factors associated with term fetal growth restriction (FGR) and immediate perinatal outcomes in these pregnancies. Methods: This was a retrospective cohort study conducted at a regional obstetric unit in Hong Kong over a 6-year period. All singleton livebirths delivered at term (≥37 weeks of gestation) were analysed. Those with major congenital abnormalities were excluded. Maternal epidemiological and anthropometric characteristics, presence of antenatal complications (gestational diabetes and medical disorders), and pregnancy outcomes (need for labour induction, mode of delivery, Apgar scores, occurrence of shoulder dystocia, and birth trauma) were compared between those with FGR (defined as birthweight ≤10th percentile for gestation) and those with birthweight appropriate for gestational age. Logistic regression analysis was conducted to identify risk factors associated with FGR. Results: From 2012 to 2017, 24 010 singleton term livebirths were stratified into FGR (n=2425, 10%), appropriate for gestational age (n=19 162, 80%), and large for gestational age. Those classified as FGR were compared with those appropriate for gestational age pregnancies. A logistic regression model confirmed that the key risk factors for FGR included maternal underweight (adjusted odds ratio [OR]=1.88), hypertensive disorders of pregnancy (adjusted OR=1.78), smoking (adjusted OR=2.02), and antenatal anaemia (adjusted OR=1.20), whereas multiparity, gestational diabetes, and hepatitis B antigen carrier status were apparently protective. Pregnancies with FGR were more likely to undergo induction of labour, but were less likely to have shoulder dystocia, Caesarean section, or postpartum haemorrhage. Conclusion: Despite the inherent risks associated with FGR at term, the immediate perinatal outcomes of these pregnancies appeared to be comparable to those appropriate for gestational age.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk factors and pregnancy outcomes of term fetal growth restriction

2019

Hong Kong J Gynaecol Obstet Midwifery

View full text Add to dashboard Cite

show abstract

“…Aunque el sobrepeso y la obesidad aumentan el riesgo de preeclampsia solo de dos a tres veces, el sobrepeso y la obesidad son altamente prevalentes en todo el mundo y, por lo tanto, representan más del 40 por ciento de los casos de preeclampsia 20 . La explicación fisiopatológica es claramente derivada de la disfunción del metabolismo de los lípidos y del síndrome metabólico asociado con los factores antiangiogenicos expresados productos de la disfunción endotelial como son el sflt-1 y PIGF 30 .…”

Section: Obesidadunclassified

Factores de riesgo de preeclampsia, una actualización desde la medicina basada en evidencias

Guevara-Ríos¹,

Gonzales-Medina²

2019

Investigación Materno Perinatal

View full text Add to dashboard Cite

La preeclampsia constituye un problema de salud pública en medicina materno perinatal y el reconocimiento de los factores de riesgo es de vital importancia para su manejo inicial. Asimismo, el vertiginoso avance de la ciencia y la investigación, nos compromete a revisar desde el enfoque actual de la medicina basada en evidencias (MBE) los nuevos hallazgos que sustentan el reconocimiento de los potenciales factores riesgo de nuestras pacientes en la práctica clínica diaria. Por ello el objetivo de la presente revisión es documentar desde el enfoque de la MBE las últimas publicaciones en relación al estudio de los factores de riesgo de preeclampsia.

show abstract

“…It is not available in the United States as the Food and Drug Association (FDA) has not approved it yet. Approval in Japan is also pending …”

Section: Proposed Screening Strategies In Relation To Pathophysiologymentioning

confidence: 99%

Prediction and prevention of pre‐eclampsia in Asian subpopulation

Wataganara

Leetheeragul

Pongprasobchai

et al. 2018

J of Obstet and Gynaecol

View full text Add to dashboard Cite

The benefit of the early administration of aspirin to reduce preterm pre-eclampsia among screened positive European women from multivariate algorithmic approach (ASPRE trial) has opened an intense debate on the feasibility of universal screening. This review aims to assess the new perspectives in the combined screening of pre-eclampsia in the first trimester of pregnancy and the chances for prevention using low-dose aspirin with special emphasis on the particularities of the Asian population. PubMed, CENTRAL and Embase databases were searched from inception until 15 November 2017 using combinations of the search terms: preeclampsia, Asian, prenatal screening, early prediction, ultrasonography, pregnancy, biomarker, mean arterial pressure, soluble fms-like tyrosine kinase-1, placental growth factor, pregnancy-associated plasma protein-A and pulsatility index. This is not a systematic review or meta-analysis, so the risk of bias of the selected published articles and heterogeneity among the studies need to be considered. The prevalence of pre-eclampsia and serum levels of biochemical markers in Asian are different from Caucasian women; hence, Asian ethnicity needs to be corrected for in the algorithmic assessment of multiple variables to improve the screening performance. Aspirin prophylaxis may still be viable in Asian women, but resource implication needs to be considered. Asian ethnicity should be taken into account before implementing pre-eclampsia screening strategies in the region. The variables included can be mixed and matched to achieve an optimal performance that is appropriate for economical restriction in individual countries.

show abstract

Update on the Diagnosis and Prognosis of Preeclampsia with the Aid of the sFlt-1/ PlGF Ratio in Singleton Pregnancies

Cited by 122 publications

References 51 publications

Risk factors and pregnancy outcomes of term fetal growth restriction

Risk factors and pregnancy outcomes of term fetal growth restriction

Factores de riesgo de preeclampsia, una actualización desde la medicina basada en evidencias

Prediction and prevention of pre‐eclampsia in Asian subpopulation

Contact Info

Product

Resources

About