Updated Review on Ozone Therapy in Pain Medicine

Abstract

The use of medical ozone in the treatment of chronic pain is progressively expanding in Spain and today it is used both in public and private medical centers. However, there is a great lack of knowledge about this technology not only in primary care but also in medical specialties. Although its biochemical bases are well determined and there are various systematic reviews and meta-analyses in the literature that justify its use in pain medicine, some professionals still are prejudiced against it. The evidence level of using medical ozone according SIGN (Scotish Intercollegiate Guideline Network) criteria is similar or superior to most of the techniques used in a Pain Unit. In this paper, we have done a review on ozone therapy in pain medicine, compiling the evidence published about it.

Long-term improvement by ozone treatment in chronic pain secondary to chemotherapy-induced peripheral neuropathy: A preliminary report

“…Once they are enhanced, some tissues could use them to palliate some pro-oxidative status (at the systemic or local level) as those associated with the side effects of radiotherapy ( Clavo et al, 2005 ; Clavo et al, 2011 ; Clavo et al, 2013a ), chemotherapy ( Clavo et al, 2019 ), or CIPN. Additionally, we have described the beneficial effect of ozone treatment in different pain syndromes as refractory headaches ( Clavo et al, 2013b ), and refractory pelvic pain after cancer treatment ( Clavo et al, 2021b ), and a recent review has updated the evidence on ozone treatment in pain medicine, especially relevant in knee osteoarthritis and low-back pain ( Hidalgo-Tallon et al, 2022 ).…”

Investigating the Effect of Injectable Ozone in Treating Symptoms and Improving Performance in Patients with Tennis Elbow Disease

“…Figure 1 represents tenderness before and after the treatment. Before the treatment, 10.71%, 53.57%, and 35.71% had The efficacy of ozone therapy as a conservative treatment in pain medicine, especially shoulder, knee, and spine is well-known [7]. Several mechanisms were suggested for the ameliorating effect of ozone on pain.…”

“…On the other hand, a study compared corticosteroid and ozone injection in a clinical trial and found better outcomes following ozone injection [6]. The safety of ozone therapy in LE is not established yet in the literature, however, there is no strong evidence of harm in this treatment method [7]. In this communication, we aimed to compare the severity of pain, tenderness, and involved elbow before and after the ozone injection treatment regimen in LE.…”

Rapid and Sustained Effect of Ozone Major Autohemotherapy for Raynaud and Hand Edema in Systemic Sclerosis Patient: A Case Report

“…Side effects of these drugs are common and include hypotension, dizziness, flushing, dependent edema and headaches for calcium channel blockers [11], vasomotor reactions, myalgias, allergic reaction, chest pain, dyspepsia, nasal stuffiness, visual abnormalities for PDE5 inhibitors [11], apathy, lethargy, impaired concentration, diarrhea and/or nausea, sexual dysfunction, and antidepressant discontinuation syndrome for fluoxetine [11]. On the contrary, if performed correctly, especially with the latest generation and high precision ozone generators as recommended by the main guidelines [12], ozone therapy has a high safety profile and a very low incidence of side effects [13] and deserves to be properly studied for the treatment of this disease [14].…”