Updates in cutaneous manifestations of systemic vasculitis

Elbendary, Amira; Abdel‐Halim, Mona R. E.; Ragab, Gaafar

doi:10.1097/bor.0000000000000847

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…TAK causes mainly LVV and MVV of the larger medium-sized arteries, including the CNS [ 19 , 21 , 22 ]. Because retinal and skin vasculitis can occur, rare SVV manifestations should be considered [ 11 , 118 ].…”

Section: The Primary Vasculitidesmentioning

confidence: 99%

Spectrum of Large and Medium Vessel Vasculitis in Adults: Primary Vasculitides, Arthritides, Connective Tissue, and Fibroinflammatory Diseases

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et al. 2022

Curr Rheumatol Rep

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Purpose of Review To provide a comprehensive overview of the spectrum of large and medium vessel vasculitis in adults with primary vasculitides, arthritides, connective tissue, and fibroinflammatory diseases as well as vasculitis mimics, for an efficient differential diagnosis and initial diagnostic approach. Recent Findings Imaging has had a tremendous impact on the diagnosis of medium to large vessel vasculitis, now often replacing histopathologic confirmation and identifying new disease manifestations (e.g., intracranial disease in giant cell arteritis; vascular manifestations of IgG4-related disease). Novel diseases or syndromes involving blood vessels have been described (e.g., VEXAS-Syndrome with polychondritis). The use of the terms “medium” or “large” vessel varies considerably between medical specialties. Summary The differential diagnosis of large and medium vessel vasculitis is becoming increasingly complex as new entities or disease manifestations of known inflammatory rheumatic diseases are regularly identified. A more precise and widely recognized definition of the vessel sizes would make future research more comparable.

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Section: The Primary Vasculitidesmentioning

confidence: 99%

Spectrum of Large and Medium Vessel Vasculitis in Adults: Primary Vasculitides, Arthritides, Connective Tissue, and Fibroinflammatory Diseases

Seitz

Pop

et al. 2022

Curr Rheumatol Rep

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“…Behcet’s Disease (BD) is a systemic vasculitis of unknown etiology involving different-sized vessels presenting between the second and fourth decades of life with a higher prevalence around the historical Silk Road. Since various organs may be involved, use of appropriate imaging modalities is mandatory for the assessment of disease extent [ 40 , 41 ]. BD is marked by recurring oropharyngeal ulcers, genital ulcers, and ocular involvement.…”

Section: Autoimmune/inflammatory Disorders and Vasculitidesmentioning

confidence: 99%

“…Genital ulcers are smaller and occur less frequently. Other common cutaneous lesions include erythema-nodosum-like nodules, pseudofolliculitis, papulopustular lesions, acneiform nodules, and superficial thrombophlebitis ( Figure 7 C,D) [ 41 , 42 ].…”

Section: Autoimmune/inflammatory Disorders and Vasculitidesmentioning

confidence: 99%

Imaging More than Skin-Deep: Radiologic and Dermatologic Presentations of Systemic Disorders

et al. 2022

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Background: Cutaneous manifestations of systemic diseases are diverse and sometimes precede more serious diseases and symptomatology. Similarly, radiologic imaging plays a key role in early diagnosis and determination of the extent of systemic involvement. Simultaneous awareness of skin and imaging manifestations can help the radiologist to narrow down differential diagnosis even if imaging findings are nonspecific. Aims: To improve diagnostic accuracy and patient care, it is important that clinicians and radiologists be familiar with both cutaneous and radiologic features of various systemic disorders. This article reviews cutaneous manifestations and imaging findings of commonly encountered systemic diseases. Conclusions: Familiarity with the most disease-specific skin lesions help the radiologist pinpoint a specific diagnosis and consequently, in preventing unnecessary invasive workups and contributing to improved patient care.

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“…In patients with CV, radiological and laboratory evaluations should be performed to investigate systemic involvement [ 4 ]. Since histopathological diagnosis takes time, many patients with clinical suspicion of CV are exposed to unnecessary laboratory examinations or immunosuppressive therapies.…”

Section: Introductionmentioning

confidence: 99%

Dermoscopic Features of Cutaneous Vasculitis

Karstarli Bakay,

Kacar,

Gonulal

et al. 2024

Dermatol Pract Concept

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Introduction: Dermoscopy has become widespread in the diagnosis of inflammatory skin diseases. Cutaneous vasculitis (CV) is characterized by inflammation of vessels, and a rapid and reliable technique is required for the diagnosis. Objectives: We aimed to define CV dermoscopic features and increase the diagnostic accuracy of dermoscopy with machine learning (ML) methods. Methods: Eighty-nine patients with clinically suspected CV were included in the study. Dermoscopic images were obtained before biopsy using a polarized dermoscopy. Dermoscopic images were independently evaluated, and interobserver variability was calculated. Decision Tree, Random Forest, and K-Nearest Neighbors were used as ML classification models. Results: The histopathological diagnosis of 58 patients was CV. Three patterns were observed: homogeneous pattern, mottled pattern, and meshy pattern. There was a significant difference in background color between the CV and non-CV groups (P = 0.001). The milky red and livedoid background color were specific markers in the differential diagnosis of CV (sensitivity 56.7%, specificity 96.3%, sensitivity 29.4%, specificity 99.2%, respectively). Red blotches were significantly more common in CV lesions (P = 0.038). Red dots, comma vessels, and scales were more common in the non-CV group (P = 0.002, P = 0.002, P = 0.003, respectively). Interobserver agreement was very good for both pattern (???? = 0.869) and background color analysis (???? = 0.846) (P < 0.001). According to ML classifiers, the background color and lack of scales were the most significant dermoscopic aspects of CV. Conclusions: Dermoscopy may guide as a rapid and reliable technique in CV diagnosis. High accuracy rates obtained with ML methods may increase the success of dermoscopy.

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Updates in cutaneous manifestations of systemic vasculitis

Cited by 8 publications

References 39 publications

Spectrum of Large and Medium Vessel Vasculitis in Adults: Primary Vasculitides, Arthritides, Connective Tissue, and Fibroinflammatory Diseases

Spectrum of Large and Medium Vessel Vasculitis in Adults: Primary Vasculitides, Arthritides, Connective Tissue, and Fibroinflammatory Diseases

Imaging More than Skin-Deep: Radiologic and Dermatologic Presentations of Systemic Disorders

Dermoscopic Features of Cutaneous Vasculitis

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