Updates in diabetic peripheral neuropathy

Abstract

Diabetes has become one of the largest global health-care problems of the 21 st century. According to the Centers for Disease Control and Prevention, the population prevalence of diabetes in the US is approaching 10% and is increasing by 5% each year. Diabetic neuropathy is the most common complication associated with diabetes mellitus. Diabetes causes a broad spectrum of neuropathic complications, including acute and chronic forms affecting each level of the peripheral nerve, from the root to the distal axon. This review will focus on the most common form, distal symmetric diabetic polyneuropathy. There has been an evolution in our understanding of the pathophysiology and the management of diabetic polyneuropathy over the past decade. We highlight these new perspectives and provide updates from the past decade of research.

Microarray Analysis of Long Noncoding RNAs in Female Diabetic Peripheral Neuropathy Patients

“…Previous studies supported the hypothesis that DPN develops as a result of chronic hyperglycemia [4]. However, more recent data seem to indicate that the development of DPN is not necessarily strictly glucocentric but also involves other risk factors that cause nerve and microvascular injury, especially in type 2 DM patients [5].…”

A Case for Alpha-Lipoic Acid as an Alternative Treatment for Diabetic Polyneuropathy

“…The following criteria were used to select studies: (1) RCTs and open-label trials on ALA, (2) review articles and meta-analyses of RCTs on ALA, (3) study population consisting of patients with diabetes mellitus, peripheral neuropathic pain, and/or metabolic syndrome. Language was a restriction in the search strategy; only articles in English were selected.…”

“…Diabetes is among the most prevalent chronic diseases of the 21 st century, with an estimation of 30.3 million people living with diabetes (1,2). The most common diabetic complication is diabetic polyneuropathy (DPN), which has a lifetime prevalence of approximately 50% in patients with diabetes (1).…”

“…The most common diabetic complication is diabetic polyneuropathy (DPN), which has a lifetime prevalence of approximately 50% in patients with diabetes (1). DPN significantly lowers quality of life as patients experience symptoms such as pain, abnormal sensation, muscle weakness, gait disturbances, and increased fall risk.…”

Avaliação Da Velocidade De Condução Da Fibra Muscular Em Indivíduos Diabéticos Com E Sem Neuropatia Periférica

“…The subjects were divided into three groups: healthy (n = 7), diabetic without DPN (n = 8) and diabetic with DPN (n = 7). Both diabetic groupsshowed reduced MFCV when compared to control, which is even lower for diabetic with DPN (5.75±0.22 vs. 3.71±0.21, p<0.000001) than for diabetic without DPN (4.76±0.41, p<0.0001 [6]. Mais tarde aparecem os primeiros sinais clínicos de disfunções motoras que consistem na perda da força nos músculos distais localizados nos membros inferiores [7,8], afetando principalmente músculos com maior proporção de fibras do tipo I como o Tibial Anterior (TA) [9,10].…”