UPLC–ESI–Q‐TOF–MS/MS analysis of anticancer fractions from <i>Ophiocordyceps xuefengensis</i> and <i>Ophiocordyceps sinensis</i>

Qin, You; Zhou, Rongrong; Jin, Jian; Xie, Jing; Liu, Hao; Cai, Ping; Shu, Jun; Zhao, Yahui; Huang, Luqi; Zhang, Shuihan

doi:10.1002/bmc.4841

Cited by 8 publications

(4 citation statements)

References 36 publications

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“…Among these compounds, 68 existed in both O. xuefengensis and O. sinensis . [53] Thus, in addition to cultured C. militaris and mycelial products of O. sinensis , native and cultivated O. xuefengensis may also have its role to play in substituting O. sinensis in Cordyceps -based therapeutics.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, a synchronized effort between the cultivated Cordyceps industry and scientific research communities is needed to future-proof this important industry. [53] Thus, in addition to cultured C. militaris and mycelial products of O. sinensis, native and cultivated O. xuefengensis may also have its role to play in substituting O. sinensis in Cordyceps-based therapeutics.…”

Section: Discussionmentioning

confidence: 99%

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Cultivated Cordyceps : A Tale of Two Treasured Mushrooms

Anyu¹,

Zhang²

2021

Chinese Medicine and Culture

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History of Ophiocordyceps sinensisCordyceps as a health supplement has been used for many centuries. O. sinensis is a naturally existent fungus-caterpillar complex that has been used in Chinese and Tibetan traditional medicine since the 15 th century. [3] O. sinensis is highly precious because it is harvested from remote locations of about 3800 m above sea level in Tibet, Qinghai, Yunnan, Sichuan, and Gansu provinces. Due to the limited quantity

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cultivated Cordyceps : A Tale of Two Treasured Mushrooms

Anyu¹,

Zhang²

2021

Chinese Medicine and Culture

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“…The oxidants in tobacco smoke channel the cell fortifications in plasma. Smokers should eat 2-3 times more ascorbate than non-smokers to achieve a comparable level of ascorbate in the blood [83], nonetheless, they only sometimes do. In assessments of sperm from smokers and non-smokers [84] the amount of sperm and the degree of motile sperm decay basically in smokers, and this reducing was dependent upon the part and term of smoking.…”

Section: Birth Defects Childhood Tumour and Oxidationmentioning

confidence: 99%

Broad Efficacy of Scavenging Free Radicals: Cordyceps sp.

Deshmukh¹,

Singh²,

Sandhu³

2021

Antioxidants - Benefits, Sources, Mechanisms of Action

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Scavenging free radical potency of cordycepin is the major bioactive segment extricated from Cordyceps species. In some new years, Cordyceps has gotten growing thought inferable from its distinctive restorative/pharmacological tests. This assessment reviews continuous explores on the counter oxidant impacts and the associated analyses of Cordyceps species. The results from our review show that Cordyceps of the cordycepin applies protective effects against hostile to oxidant injury for certain, afflictions including constant obstructive pneumonic infection (COPD), hepatitis, asthma, cerebral paralysis, Parkinson’s illness (PD), coronary course sickness (CAD), Alzheimer illness, respiratory failure, malignancy infection, maturing, waterfalls, and mind brokenness. Cordyceps coordinates the NF-κB, RIP2/Caspase-1, Akt/GSK-3β/p70S6K, TGF-β/Smads, and Nrf2/HO-1 hailing pathways among others of cordycepin. A couple of assessments focusing in on Cordyceps auxiliaries were surveyed and found to down metabolic speed of Cordyceps and augmentation its bioavailability. In addition, cordycepin further developed opposition, prevented the duplication of viral RNA, and covered cytokine storms, therefore proposing its capacity to treat COVID-19 and other viral defilements. From the accumulated and assessed information, this article gives the speculative reason to the clinical usages of cordycepin and inspects the way for future assessments focusing in on expanding the restorative use of Cordyceps species. Cordycepin and its analogs show unfathomable potential as the accompanying new class of against oxidant specialists.

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“…It is a widely known medicinal herb in the world primarily functioned as remedy for anti-cancer [2]. Pure active substances isolated from O.sinensis, namely polysaccharide, cordyceps acid, cordycepin and adenosine [3,4], have been certified to possess anti-oxidant, anti-aging, anti-cancer and strengthen the immune system [5]. In addition, it has been certificated as a novel food source according to State Food and Drug Administration of Ministry of Public Health of China [1].…”

Section: Introductionmentioning

confidence: 99%

Selection and validation of reference genes for RT-qPCR in ophiocordyceps sinensis under different experimental conditions

He,

Wang,

et al. 2024

PLoS ONE

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The Chinese caterpillar mushroom, Ophiocordyceps sinensis (O. sinensis), is a rarely medicinal fungus in traditional chinese herbal medicine due to its unique medicinal values, and the expression stability of reference genes is essential to normalize its gene expression analysis. In this study, BestKeeper, NormFinder and geNorm, three authoritative statistical arithmetics, were applied to evaluate the expression stability of sixteen candidate reference genes (CRGs) in O. sinensis under different stress [low temperature (4°C), light treatment (300 lx), NaCl (3.8%)] and different development stages (mycelia, primordia and fruit bodies) and formation of morphologic mycelium (aeriasubstrate, hyphae knot mycelium). The paired variation values indicated that two genes could be enough to accurate standardization exposed to different conditions of O.sinensis. Among these sixteen CRGs, 18S ribosomal RNA (18S rRNA) and beta-Tubulin (β-TUB) showed the topmost expression stability in O.sinensis exposed to all conditions, while glutathione hydrolase proenzym (GGT) and Phosphoglucose isomerase (PGI) showed the least expression stability. The optimal reference gene in different conditions was various. β-TUB and Ubiquitin (UBQ) were identified as the two most stable genes in different primordia developmental stage, while phosphoglucomutase (PGM) with elongation factor 1-alpha (EF1-α) and 18S rRNA with UBQ were the most stably expressed for differentially morphologic mycelium stages and different stresses, respectively. These results will contribute to more accurate evaluation of the gene relative expression levels in O.sinensis under different conditions using the optimal reference gene in real-time quantitative PCR (RT-qPCR) analysis.

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UPLC–ESI–Q‐TOF–MS/MS analysis of anticancer fractions from Ophiocordyceps xuefengensis and Ophiocordyceps sinensis

Cited by 8 publications

References 36 publications

Cultivated Cordyceps : A Tale of Two Treasured Mushrooms

Cultivated Cordyceps : A Tale of Two Treasured Mushrooms

Broad Efficacy of Scavenging Free Radicals: Cordyceps sp.

Selection and validation of reference genes for RT-qPCR in ophiocordyceps sinensis under different experimental conditions

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