UPLC‐MS/MS Profile of Alkaloids with Cytotoxic Properties of Selected Medicinal Plants of the <i>Berberidaceae</i> and <i>Papaveraceae</i> Families

Jiang

J of Separation Science

et al. 2019

Berberine alkaloids, a group of protoberberine alkaloids under the classification of isoquinoline alkaloids, include berberine, coptisine, palmatine, columbamine, dehydrocorydaline, jatrorrhizine, and epiberberine from natural sources. Studies have shown that berberine alkaloids have various pharmacological functions, such as antibacterial, antiviral, blood pressure‐lowering, hypoglycaemic, antiarrhythmia, and anticancer effects. Therefore, it is worthwhile to develop analytical methods to investigate the pharmacokinetics and activity mechanisms of berberine alkaloids and to study berberine alkaloids more comprehensively. Current analytical methods for berberine alkaloids include liquid chromatography, thin‐layer chromatography, ultraviolet spectroscopy, capillary electrophoresis, and gas chromatography. The most widely used detection method is mass spectrometry. In order to provide a systematic and comprehensive summary and to serve as a reference for the future pharmacokinetics studies and analysis of berberine alkaloids, analytical methods for natural berberine alkaloids that have been used in the past ten years are reviewed here.

“…This kind of method is frequently used for TCM analytes . For example, berberine in Dicentra spectabilis (L.) Lem., Fumaria officinalis L., and Glaucium flavum Crantz.…”

Section: Methodsmentioning

confidence: 99%

Section: Lc-ms/msmentioning

confidence: 99%

A review on analytical methods for natural berberine alkaloids

Jiang

J of Separation Science

et al. 2019

Journal of Integrative Medicine

“…In addition, it is unknown whether berberine, as a constituent of traditional medicine, rather than as an isolate, could exert the same effectiveness. Berberine is a natural alkaloid found in various medicinal plant species [36,[222][223][224][225][226][227][228][229] (Table 11). These medicinal plants could be useful in the prevention of dementia associated with metabolic disorders.…”

Section: Limitations and Future Perspectivesmentioning

confidence: 99%

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Shinjyo

Parkinson

Bell

et al. 2020

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Food and Chemical Toxicology

“…Moreover, Bournine et al (2013) studied the chemical composition of roots and isolated two new alkaloids, namely protopine and bocconoline. Two more alkaloids were also isolated and identified in aerial parts as N,N-dimethyl-hernovine and sanguinarine (Och et al, 2017). However, according to Doncheva et al (2016) alkaloid profile of the species is highly depended on genotype, with three chemotypes being suggested in terms of aporphines, protopines and morpinanes content.…”

Section: Chemical Compositionmentioning

confidence: 99%

Halophytic herbs of the Mediterranean basin: An alternative approach to health

Petropoulos

Karkanis

Martins

et al. 2018

Wild native species are usually grown under severe and stressful conditions, while a special category includes halophytic species that are tolerant to high salinity levels. Native halophytes are valuable sources of bioactive molecules whose content is higher in saline than normal conditions, since the adaptation to salinity mechanisms involve apart from changes in physiological functions the biosynthesis of protectant molecules. These compounds include secondary metabolites with several beneficial health effects which have been known since ancient times and used for medicinal purposes. Recent trends in pharmaceutical industry suggest the use of natural compounds as alternative to synthetic ones, with native herbs being strong candidates for this purpose due to their increased and variable content in health promoting compounds. In this review, an introductory section about the importance of native herbs and halophyte species for traditional and modern medicine will be presented. A list of the most important halophytes of the Mediterranean basin will follow, with special focus on their chemical composition and their reported by clinical and ethnopharmacological studies health effects. The review concludes by suggesting future requirements and perspectives for further exploitation of these valuable species within the context of sustainability and climate change.