Upper Gastrointestinal Disease in Chronic Renal Failure

Margolis, David M.

doi:10.1001/archinte.1978.03630330014007

Cited by 49 publications

(8 citation statements)

References 13 publications

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“…Gastrointestinal bleeding is a frequently reported complication of chronic renal failure [2,10,26]. This has been attributed to a number of pathologic abnormalities including peptic ulceration [20], gastritis and gastric ulceration [2] and gastric telangiectasias [3,26].…”

Section: Discussionmentioning

confidence: 99%

Ranitidine pharmacokinetics in continuous ambulatory peritoneal dialysis

Sica

Comstock

Harford

et al. 1987

Eur J Clin Pharmacol

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Ranitidine kinetics in renal failure were evaluated in six patients undergoing continuous ambulatory peritoneal dialysis (CAPD). On separate occasions each patient received either 50 mg intravenously (i.v.) or 150 mg orally of ranitidine HCl. Following i.v. administration, the plasma concentration vs time curve was best described by a two compartment model with firstorder elimination. The mean +/- SD distribution and elimination rate constants were 2.47 +/- 0.78 and 0.098 +/- 0.013 h, respectively. The area under the serum concentration vs time curve after the i.v. dose was 5979 +/- 2870 micrograms X h X l-1, resulting in a mean volume of distribution of 76.8 l and a total body clearance of 126 ml X min-1. Following oral administration the observed maximum plasma concentration was 904 +/- 483 micrograms X l-1 at 4.2 +/- 1.8 h, and the bioavailability was 69.7 +/- 35.6%. The peritoneal clearance of ranitidine was 3.2 +/- 0.7 and 2.6 +/- 0.6 ml X min-1 for the i.v. and oral groups, respectively. The amount of drug removed by dialysis was 561.2 +/- 336.2 micrograms for the i.v. and 1197.1 +/- 602.3 micrograms for the oral group. Four patients in the i.v. group had urine output during the study period with renal ranitidine clearance values of 9.9 +/- 9.9 ml X min-1. Two patients in the oral group had urine output and corresponding renal ranitidine clearance values of 5.1 and 20.1 ml X min-1. A dosage regimen for ranitidine is proposed based on ranitidine kinetics in patients undergoing CAPD.

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Section: Discussionmentioning

confidence: 99%

Ranitidine pharmacokinetics in continuous ambulatory peritoneal dialysis

Sica

Comstock

Harford

et al. 1987

Eur J Clin Pharmacol

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“…The 50 -70 age group was the most represented with 43.4% of patients. In the literature, Varma [9] in India, David etcollaborateurs [10] in the USA, Rey et collaborateurs [11] in France, Gary and Zuckerman in the USA [12] reported an average age in 42.26, 43.1, 50.1 and 57 years respectively. Low life expectancy, socio-economic conditions, diet and the high frequency of predisposing pathologies (hypertension, diabetes) could also explain this difference.…”

Section: Discussionmentioning

confidence: 99%

Digestive Pathologies during Chronic Renal Failure in the Nephrology and Haemodialysis Department at the University Hospital Center of Point G in Mali

Samaké¹,

Sy²,

Yattara³

et al. 2020

OJCD

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Introduction: Chronic kidney disease (CKD) is the progressive and irreversible loss of kidney function. It exposes to many complications, among which, digestive complications. In Mali, we do not have data on the prevalence of digestive pathologies in people with chronic renal failure, hence the interest of this study. Objective: To determine the prevalence of digestive pathologies and to describe their manifestations during chronic renal failure. Patients and Methods: This was a prospective cross-sectional study conducted from September 2016 to August 2017, a period of 12 months. Included were patients hospitalized in our department with CKD who received digestive endoscopy and/or liver serology. Results: Seventy-one patients underwent digestive endoscopy with oesogastroduodenal fibroscopy (60 patients), rectoscopy (6 patients) and anoscopy (5 patients), i.e.

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“…Many factors may be related. For example, dis turbances in serum gastrin [17][18][19], in gastric acid secre tion [9,11,17,19], in the mucosal barrier [20][21][22], in the clotting process [23][24][25], etc. were caused, either separ ately or together, by chronic renal failure, and have been proposed as important elements in uppergastrointestinal hemorrhaging.…”

Section: Discussionmentioning

confidence: 99%

Hypochlorhydria and Hypergastrinemia and Their Association with Gastrointestinal Bleeding in Undialyzed and Hemodialyzed Patients

Muto¹,

Asano²,

Hosoda³

et al. 1988

Nephron

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In 15 undialyzed (UD) patients and 26 hemodialyzed (HD) patients, (1) basal and test meal-stimulated gastrin concentrations, (2) basal and pentagastrin-stimulated gastric acid outputs, and (3) endoscopic examinations were studied. Also studied were the morphological and functional differences of the gastrointestinal tract between UD and HD patients. HD patients had lower gastric acid outputs and higher circulating gastrin levels in the fasting state. After a test meal, the peak increment of serum gastrin in UD and HD patients occurred 30 and 60 min later, respectively, and the response was prolonged in each group. Endoscopic findings showed that the incidence of abnormalities in each group was very similar, that is, the most predominant lesions in each group were hemorrhagic and atrophic gastritis. The data suggested that the response to gastrin of parietal cell and the defensive mechanism of gastrointestinal mucosa in HD patients may be impaired.

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Upper Gastrointestinal Disease in Chronic Renal Failure

Cited by 49 publications

References 13 publications

Ranitidine pharmacokinetics in continuous ambulatory peritoneal dialysis

Ranitidine pharmacokinetics in continuous ambulatory peritoneal dialysis

Digestive Pathologies during Chronic Renal Failure in the Nephrology and Haemodialysis Department at the University Hospital Center of Point G in Mali

Hypochlorhydria and Hypergastrinemia and Their Association with Gastrointestinal Bleeding in Undialyzed and Hemodialyzed Patients

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