Upper urothelial tumours and the Balkan nephropathy

Radovanović, Zoran; Velimirović, D; Naumović, T

doi:10.1016/0277-5379(90)90239-p

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…The fact that GAGs are constituents of the basement mem branes and of the extracellular matrix situated all along the nephron most probably accounts for the lack of reliability of this parameter in indicating tubular damage when com pared to pr microglobulin and NAG. A pronounced in crease of urinary GAGs in subjects at the suspect and diseased stage of BEN could be a sign of other nephrologi cal alterations often seen in this disease [8,18].…”

Section: Discussionmentioning

confidence: 99%

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Urinary Glycosaminoglycans in Different Phases of Balkan Endemic Nephropathy

Juretić

Čvorišćec²,

Vuković-Holjevac³

et al. 1993

Nephron

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The relationship between glycosaminoglycans and β₂-microglobulin, glycosaminoglycans and N-acetyl-β-D-glucosaminidase as well as the relationship between the chondroitin sulfate/heparan sulfate ratio and SDS electrophoresis in the urine of subjects from the endemic area of Balkan nephropathy was studied in order to establish a method for early detection of this disease. The results show an unquestionable increase in urinary excretion of total glycosaminoglycans in subjects with or suspected of having Balkan endemic nephropathy while the chondroitin sulfate/heparan sulfate ratio was not statistically different between the groups studied. Thus, the chondroitin sulfate/heparan sulfate ratio cannot be used as a cheap and quick semiquantitative method for the diagnosis of early tubular damage in Balkan endemic nephropathy. However, the determination of total glycosaminoglycans in the urine of subjects from endemic areas proved to be valuable additional information helping with the diagnosis of Balkan endemic nephropathy.

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Section: Discussionmentioning

confidence: 99%

“…BEN is characterized by a degener ation of tubular cells, eventually accompanied by glomeru lar lesions in the late phase [1,18].…”

Section: Discussionmentioning

confidence: 99%