Upregulation of circular RNA hsa_circ_0007534 predicts unfavorable prognosis for NSCLC and exerts oncogenic properties in vitro and in vivo

Qi, Yi; Zhang, Bingquan; Wang, Junting; Yao, Mengna

doi:10.1016/j.gene.2018.07.028

Cited by 35 publications

(37 citation statements)

References 23 publications

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“…After abstract and full article review, 24 published articles were enrolled for the final analysis. Among them, 5 articles investigated diagnostic value of circRNAs in lung cancer [24,[33][34][35][36], and 19 studies examined prognostic information related to overall survival [32,[37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54]. The period of the eligible studies ranged from 2017 to 2018 with a total of 2122 individuals.…”

Section: Resultsmentioning

confidence: 99%

Potential Diagnostic and Prognostic Biomarkers of Circular RNAs for Lung Cancer in China

Wang

Jiang

Lei

et al. 2019

BioMed Research International

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Emerging evidence demonstrated that circular RNAs (circRNAs) were dysregulated in lung cancer, indicating that circRNAs might serve as novel diagnostic and prognostic biomarkers for lung cancer. However, the clinical value of circRNAs on lung cancer remains unclear. This study aimed to evaluate the efficiency of circRNAs in the diagnosis and prognosis for lung cancer in China. 2122 Chinese individuals were enrolled in this investigation for assessment of diagnostic value and examination of prognostic analysis. In the diagnostic analysis, the pooled sensitivity, specificity, PLR, NLR, DOR, and AUC of the sROC curve with their 95% CIs were 0.80 (95%CI: 0.74-0.84), 0.80 (95%CI: 0.73-0.86), 3.97 (95%CI: 2.80-5.62) and 0.26 (95%CI: 0.19-0.34), 15.51 (95%CI: 8.76-24.47), and 0.85 (95%CI: 0.82-0.88), respectively. As for the prognostic power of circRNAs, lung cancer patients with higher expression levels of circRNAs tend to possess lower overall survival with the overall pooled HR (1.70, 95%CI: 1.26-2.29). Furthermore, in stratified analysis, upregulated and downregulated circRNAs were manifested to exert significant effects on prognosis with HR values of 2.17 (95%CI: 1.74-2.72) and 0.52 (95%CI: 0.34-0.80). This study validates that circRNAs are promising diagnostic and predictive biomarkers for lung cancer patients in China.

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Section: Resultsmentioning

confidence: 99%

Potential Diagnostic and Prognostic Biomarkers of Circular RNAs for Lung Cancer in China

Wang

Jiang

Lei

et al. 2019

BioMed Research International

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“…This circRNA sponged miR-330-5p, thus increasing FAM83A expression and regulating MAPK/ERK signal transduction [98]. CircDDX42 [111] and circARHGAP10 [71] also correlated with worse NSCLC overall survival.…”

Section: Circrna Clinical Relevance As Cancer Biomarkersmentioning

confidence: 93%

The Potential of Circular RNAs as Cancer Biomarkers

Brown

Chinnaiyan

2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Circular RNA (circRNA) is a covalently closed RNA structure that has several proposed functions related to cancer development. Recently, cancer-specific and tissue-specific circRNAs have been identified by high throughput sequencing and are curated in publicly available databases. CircRNAs have features that are ideal properties of biomarkers, including conservation, abundance, and stability in plasma, saliva, and urine. Many circRNAs with predictive and prognostic significance in cancer have been described, and functional mechanisms for some circRNAs have been suggested. CircRNA also has great potential as a non-invasive biomarker for early cancer detection, although further investigation is necessary before clinical application is feasible.

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“…Hsa_circ_0007534 is an exon-derived circRNA that originates from the protein-coding gene DEAD-box helicase 42 ( DDX42 ) 38. It was found to be upregulated in a variety of cancers, including glioma,40 osteosarcoma,41 breast cancer,42 non-small cell lung cancer,43 and CRC 44. Li et al found that hsa_circ_0007534 promoted glioma cell proliferation and migration via upregulating Zic family member 5 ( ZIC5 ) expression by sponging miR-761 40.…”

Section: Circrnas Regulate the Proliferation And Progression Of Crcmentioning

confidence: 99%

<p>Emerging roles of circular RNAs in colorectal cancer</p>

Hao¹,

Liu²,

Qu³

et al. 2019

OTT

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Circular RNAs (circRNAs) are a newly discovered class of endogenous non-coding RNAs. Owing to the development of high-throughput sequencing, researchers have identified thousands of circRNAs. Emerging evidence suggests that circRNAs are involved in various tumor cell processes, including proliferation, apoptosis, invasion and migration. Because of their high stability and abundance, tissue-specific expression, and easy detection, circRNAs are considered ideal biomarkers for cancer diagnosis and prognosis. An increasing number of studies have recently demonstrated that circRNAs are closely associated with colorectal cancer (CRC). CRC is the third most common cancer and the second leading cause of cancer-related death globally. Thus, understanding the molecular mechanisms involved in the development and progression of CRC is vital. In this review, we summarize the current literature regarding human circRNAs related to CRC and present an overview of the potential clinical implications of circRNAs with respect to CRC.

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Upregulation of circular RNA hsa_circ_0007534 predicts unfavorable prognosis for NSCLC and exerts oncogenic properties in vitro and in vivo

Cited by 35 publications

References 23 publications

Potential Diagnostic and Prognostic Biomarkers of Circular RNAs for Lung Cancer in China

Potential Diagnostic and Prognostic Biomarkers of Circular RNAs for Lung Cancer in China

The Potential of Circular RNAs as Cancer Biomarkers

<p>Emerging roles of circular RNAs in colorectal cancer</p>

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