Upregulation of Endothelial HLA Class II is a Marker of Antibody-Mediated Rejection in Heart Allograft Biopsies

Cai, Qi; Moore, Samantha A.; Hendricks, Allen R.; Torrealba, José

doi:10.1016/j.transproceed.2020.01.049

Cited by 2 publications

(1 citation statement)

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“…In one such study, simultaneous bulk analysis of the transcriptome and epigenome of ECs across 12 organs showed that ECs are epigenetically pre-programmed for a response to immunological challenges, including viral infection [ 106 ]. Future studies will inform on the contributions of distinct IMEC subsets to immunity in normal tissue homeostasis, tumor immunity, and graft rejection reactions [ 107 , 108 ].…”

Section: Ec Heterogeneity In Tissue Repairmentioning

confidence: 99%

Endothelial cell plasticity at the single-cell level

et al. 2021

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The vascular endothelium is characterized by a remarkable level of plasticity, which is the driving force not only of physiological repair/remodeling of adult tissues but also of pathological angiogenesis. The resulting heterogeneity of endothelial cells (ECs) makes targeting the endothelium challenging, no less because many EC phenotypes are yet to be identified and functionally inventorized. Efforts to map the vasculature at the single-cell level have been instrumental to capture the diversity of EC types and states at a remarkable depth in both normal and pathological states. Here, we discuss new EC subtypes and functions emerging from recent single-cell studies in health and disease. Interestingly, such studies revealed distinct metabolic gene signatures in different EC phenotypes, which deserve further consideration for therapy. We highlight how this metabolic targeting strategy could potentially be used to promote (for tissue repair) or block (in tumor) angiogenesis in a tissue or even vascular bed-specific manner.

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Section: Ec Heterogeneity In Tissue Repairmentioning

confidence: 99%