Upregulation of Glutamic-Oxaloacetic Transaminase 1 Predicts Poor Prognosis in Acute Myeloid Leukemia

Cheng, Zhiheng; Dai, Yifeng; Zeng, Tiansheng; Liu, Yan; Cui, Longzhen; Qian, Tingting; Si, Chaozeng; Huang, Wenhui; Pang, Ying; Xu, Ye; Shi, Jianxin; Fu, Lin

doi:10.3389/fonc.2020.00379

Cited by 11 publications

(10 citation statements)

References 28 publications

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“…In addition, altered gene expression is associated with the prognosis and may guide the treatment of AML patients. We found that AML patients with high expression of FHL2 , DDIT4 , GOT1 and iASPP tend to have shorter survival, while those with high expression of PAK2 and DOK7 have better outcomes ( 3 – 7 ). The role of epigenetics, which does not involve changes in DNA sequence, in leukemogenesis is of increasing concern.…”

Section: Introductionmentioning

confidence: 80%

Prognostic Value of MicroRNA-20b in Acute Myeloid Leukemia

et al. 2021

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Acute myeloid leukemia (AML) is a highly heterogeneous disease that requires fine-grained risk stratification for the best prognosis of patients. As a class of small non-coding RNAs with important biological functions, microRNAs play a crucial role in the pathogenesis of AML. To assess the prognostic impact of miR-20b on AML in the presence of other clinical and molecular factors, we screened 90 AML patients receiving chemotherapy only and 74 also undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) from the Cancer Genome Atlas (TCGA) database. In the chemotherapy-only group, high miR-20b expression subgroup had shorter event-free survival (EFS) and overall survival (OS, both P < 0.001); whereas, there were no significant differences in EFS and OS between high and low expression subgroups in the allo-HSCT group. Then we divided all patients into high and low expression groups based on median miR-20b expression level. In the high expression group, patients treated with allo-HSCT had longer EFS and OS than those with chemotherapy alone (both P < 0.01); however, there were no significant differences in EFS and OS between different treatment subgroups in the low expression group. Further analysis showed that miR-20b was negatively correlated with genes in “ribosome,” “myeloid leukocyte mediated immunity,” and “DNA replication” signaling pathways. ORAI2, the gene with the strongest correlation with miR-20b, also had significant prognostic value in patients undergoing chemotherapy but not in the allo-HSCT group. In conclusion, our findings suggest that high miR-20b expression is a poor prognostic indicator for AML, but allo-HSCT may override its prognostic impact.

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Section: Introductionmentioning

confidence: 80%

Prognostic Value of MicroRNA-20b in Acute Myeloid Leukemia

et al. 2021

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“…GOT1 overexpression was shown to promote cisplatin resistance in NSCLC [ 20 ]. In acute myeloid leukemia, upregulation of GOT1 was also found to be associated with a worse prognosis [ 21 ]. However, in cervical cancer, upregulation of GOT1 mRNA is a protective factor, indicating a better prognosis [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Proteomic Analysis of Colon Cancer Tissue Revealed the Reason for the Worse Prognosis of Right-Sided Colon Cancer and Mucinous Colon Cancer at the Protein Level

et al. 2021

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To clarify the molecular mechanisms underlying the poor prognosis of right-sided and mucinous colon cancer at the proteomic level. A tandem mass tag-proteomics approach was used to identify differentially expressed proteins (DEPs) in colon carcinoma tissues from different locations and with different histological types to reveal the underlying mechanisms of these differences at the protein level. In additional, the DEPs were analyzed using bioinformatics methods. The proteomics profiles among colon cancers with different tumor locations and histological types were dramatically distinguished. In terms of tumor locations, the right-sided carcinoma specific DEPs may promote the tumor progression via activating inflammation, metastasis associated pathways. When referring to histological types, the mucinous colon cancers perhaps increased the invasion and metastasis through distinct mechanisms in different tumor locations. For mucinous cancer located in right-sided colon, the mucinous specific DEPs were mainly associated with ECM-related remodeling and the IL-17 signal pathway. For mucinous cancer located in left-sided colon, the mucinous specific DEPs showed a strong relationship with ACE2/Ang-(1–7)/MasR axis. The proteomics profiles of colon cancers showed distinct differences related to locations and histological types. These results suggested a distinct mechanism underlying the diverse subtypes of colon cancers.

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“…Leukemia, as a clinical disease with high morbidity and high mortality, its clinical research has not stopped [8,9] . However, But the speci c mechanism analysis is not clear, which brings great di culties to the prevention and treatment of leukemia and despite aggressive treatment, the prognosis of patients remains dismal [10] . MiRNAs plays an important role in the cancer development in leukemia [11,12] .…”

Section: Discussionmentioning

confidence: 99%

miR-22/TET2/p53-Feedback Loop Regulates Cell Proliferation and Apoptosis of k562 cells

Yao¹,

Fu²,

Chen³

et al. 2020

Preprint

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BackgroundChronic myeloid leukemia (CML) is a major global health threat due to its low cure rate and high fatality rate. Studies have reported that miR-22, TET2, and p53 play a vital role in the progression of leukemia. However, it is unclear whether there is feedback regulation between them.MethodsTransfection efficiency of miR-22 and TET2 was detected by qRT-PCR. CCK-8 assay was applied to measure the proliferation ability of K562 cells. Flow cytometry was used for evaluation the cell cycle and apoptosis rate of K562 cells after transfection. Moreover, the interaction between miR-22, TET2 and P53 was analyzed by luciferase reporter gene assay.ResultsExperiments indicated that the TET2 expression was decreased and apoptosis was increased in the miR-22 mimic group, and cell cycle was arrested in G0/G1phase, the proliferation was markedly inhibited. Meanwhile we found that TET2 can affect the expression of p53. Then, we directly proved p53 inhibition miR-22 transcription, whereas miR-22 as a transcriptional repressor, TET2 expression is negatively regulated to form a feedback loop.ConclusionsmiR-22, TET2 and p53 can form a feedback loop and thus affect cell proliferation and apoptosis of chronic myeloid leukemia cells.

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Upregulation of Glutamic-Oxaloacetic Transaminase 1 Predicts Poor Prognosis in Acute Myeloid Leukemia

Cited by 11 publications

References 28 publications

Prognostic Value of MicroRNA-20b in Acute Myeloid Leukemia

Prognostic Value of MicroRNA-20b in Acute Myeloid Leukemia

Comprehensive Proteomic Analysis of Colon Cancer Tissue Revealed the Reason for the Worse Prognosis of Right-Sided Colon Cancer and Mucinous Colon Cancer at the Protein Level

miR-22/TET2/p53-Feedback Loop Regulates Cell Proliferation and Apoptosis of k562 cells

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