Upregulation of MAD2L1 mediated by ncRNA axis is associated with poor prognosis and tumor immune infiltration in hepatocellular carcinoma: A review

Abstract

Background: The mortality rate and prognosis of patients with hepatocellular carcinoma (HCC) are well known. A variety of highly malignant human cancers express mitotic arrest deficient 2 like 1 (MAD2L1), a transcription factor that plays a critical role in their development and progression. However, MAD2L1’s particular mechanisms and effects on HCC remain uncertain. Methods: We performed a pan-cancer analysis for MAD2L1 prognosis and expression using The Cancer Genome Atlas and Genotype-Tissue Expression data in the present study. MAD2L1 may act as an oncogene in HCC, and a combination of in silico analyses, including expression, survival, and correlation analyses, were performed to identify non-coding ribonucleic acids (ncRNAs) that contribute to MAD2L1 overexpression. Results: In conclusion, MAD2L1 is most likely regulated by HCP5/miRNA-139-5p/MAD2L1 in HCC based on its upstream ncRNA-related pathway. A significant positive association was also found between MAD2L1 levels and tumor immune cell infiltration, immune cell biomarkers, and immune checkpoint expression. Conclusion: Our findings demonstrate that ncRNA-mediated upregulation of MAD2L1 in HCC is closely related to poor prognosis and tumor infiltration.

Identification of common hub genes in gastrointestinal cancers and their role in prognosis and Immune cell infiltration in hepatocellular carcinoma

“…Few studies have shown that CyclinB1 (CCNB1) is a key gene in the development of liver cancer [34]. Studies have shown that ncRNA-mediated upregulation of MAD2L1 is a predictor of adverse outcomes and tumor invasion in HCC [35]. MiR-200c-5p could inhibit the expression of the MAD2L1 gene, which led to inhibiting the migration, invasion, and proliferation of HCC cells [36].…”