2007
DOI: 10.1038/sj.leu.2404784
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Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma

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Cited by 31 publications
(24 citation statements)
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“…13 We report that the interstitial deletion results in fusion transcript in which the first noncoding exon of P2YR8 fuses to the coding region of CRLF2, thereby driving CRLF2 expression by the P2YR8 promoter. A similar mechanism was reported in a single patient with splenic lymphoma and P2YR8-SOX5 fusion 34 and is reminiscent of the common SIL-SCL (STIL-TAL1) rearrangement in T-ALL. 35 Cloning of the genomic breakpoints is required to determine whether, like SIL-SCL, the deletion is caused by aberrant V(D)J activity.…”
Section: Discussionsupporting
confidence: 67%
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“…13 We report that the interstitial deletion results in fusion transcript in which the first noncoding exon of P2YR8 fuses to the coding region of CRLF2, thereby driving CRLF2 expression by the P2YR8 promoter. A similar mechanism was reported in a single patient with splenic lymphoma and P2YR8-SOX5 fusion 34 and is reminiscent of the common SIL-SCL (STIL-TAL1) rearrangement in T-ALL. 35 Cloning of the genomic breakpoints is required to determine whether, like SIL-SCL, the deletion is caused by aberrant V(D)J activity.…”
Section: Discussionsupporting
confidence: 67%
“…A similar chimeric transcript was described in a single patient with splenic lymphoma, fusing P2RY8 to SOX5 resulting in overexpression of SOX5. 34 We extended the analysis and identified the chimeric transcript in 7 of 10 patients with overexpression of CRLF2 and in none of 8 samples with no expression of CRLF2 (supplemental Table 2). Thus, consistent with the FISH findings, 13 the interstitial deletion is more common than the IgH@ translocation.…”
Section: Genomic Analysis Of Ds-all 1009mentioning
confidence: 99%
“…P2RY8 is a member of a family of purinergic receptor genes that is expressed in hematopoietic cells, including leukemic blasts, and has previously been identified as a rare target of translocation to SOX5 in lymphoma. 72 CRLF2 alterations in B-progenitor ALL have been subsequently confirmed and identified by multiple groups, including adult ALL 61,70,71,73,74 (Table 1). CRLF2 is rearranged in five to seven percent of B-progenitor childhood ALL cases, most commonly by IGH@-CRLF2 rearrangement or the PAR1 deletion resulting in expression of P2RY8-CRLF2.…”
Section: Genetic Characterization Of Bcr-abl1-like Phà Allmentioning
confidence: 80%
“…2). P2RY8, CCR10 and RGS10, which were elevated in HCC tissues and their pair paracancerous tissues, have been reported to play roles in carcinoma [33][34][35] . Our data showed that ARRB1 was upregulated in human HCC tissues and its paracancerous tissues compared with normal liver tissues, but there was no significant difference between HCC tissues and paracancerous tissues, suggesting that ARRB1 may play an important role in hepatocellular carcinogenesis.…”
Section: Discussionmentioning
confidence: 98%