2008
DOI: 10.1016/j.biopsych.2007.01.010
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Upregulation of Voluntary Alcohol Intake, Behavioral Sensitivity to Stress, and Amygdala Crhr1 Expression Following a History of Dependence

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Cited by 300 publications
(376 citation statements)
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“…2 [6,23]. As predicted from the allostatic concept of addiction (Box 1) we found upregulated CRH activity in the central amygdala of postdependent animals during acute withdrawal and many weeks thereafter, contributing to increased ethanol intake, anxiety, and ethanol-seeking behavior, all of which can be alleviated by blockade of CRH 1 receptors [6,[23][24][25][26]. In fact, the excessive ethanol consumption appears to be a means to downregulate amygdala CRH 1 receptors [27].…”
Section: Introductionsupporting
confidence: 52%
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“…2 [6,23]. As predicted from the allostatic concept of addiction (Box 1) we found upregulated CRH activity in the central amygdala of postdependent animals during acute withdrawal and many weeks thereafter, contributing to increased ethanol intake, anxiety, and ethanol-seeking behavior, all of which can be alleviated by blockade of CRH 1 receptors [6,[23][24][25][26]. In fact, the excessive ethanol consumption appears to be a means to downregulate amygdala CRH 1 receptors [27].…”
Section: Introductionsupporting
confidence: 52%
“…1), in close proximity to the locus of highest extrahypothalamic Crh mRNA expression. Interestingly, CRH 1 receptors appear upregulated in the medial amygdala during states of increased behavioral sensitivity to stress [6]. However, most of the cellular and molecular interactions between these systems are still unknown.…”
Section: Introductionmentioning
confidence: 99%
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“…Second, studies have also implicated CRHR1 SNPs in heavy alcohol use during adolescence (Blomeyer et al, 2008) and binge drinking (Treutlein et al, 2006), and CRHR1 gene upregulation has been linked to the risk of relapse after cessation of drinking (Sommer et al, 2008). CRHR1 SNPs also interact with stressful life events to predict heavy drinking among 19-year-olds (Schmid et al, 2010).…”
Section: Discussionmentioning
confidence: 99%