Upregulation of αvβ6 integrin, a potent TGF-β1 activator, and posterior capsule opacification

Sponer, Ulrike; Pieh, Stefan; Soleiman, Afschin; Skorpik, Christian

doi:10.1016/j.jcrs.2004.05.058

Cited by 25 publications

(17 citation statements)

References 51 publications

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“…During the embryonic development of eyes, LEC proliferation and differentiation are affected by various factors outside the cells, in which TGF-β is one of the most important trans-differentiation cytokines (de Iongh et al, 2005). More and more studies confirm that TGF-β can lead to the apoptosis of LECs and induce cataract formation (Sponer et al, 2005). Under physiological conditions, TGF-β 2 is in the inactive form, and activity can be induced by some pathological changes such as surgery and trauma (Saika et al, 2005;Ou et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Role of glutathione and other antioxidants in the inhibition of apoptosis and mesenchymal transition in rabbit lens epithelial cells

Wang¹,

Zhu²,

Zheng³

2014

Genet. Mol. Res.

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ABSTRACT. This study aimed to discuss the effect and mechanism of glutathione (GSH) and catalase (CAT) on transforming growth factor beta (TGF-β)-induced lens epithelial cell (LEC) apoptosis and epithelial mesenchymal transition (EMT) to prevent and control cataracts. Healthy rabbits (4 weeks old) were randomly selected, and LECs from their lenses were cultured in vitro. The 2nd-and 3rd-generation cells were divided into 6 groups (group A: 75 pg/mL TGF-β 2

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Section: Discussionmentioning

confidence: 99%

Role of glutathione and other antioxidants in the inhibition of apoptosis and mesenchymal transition in rabbit lens epithelial cells

Wang¹,

Zhu²,

Zheng³

2014

Genet. Mol. Res.

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“…Injury by mechanical trauma can modulate integrin expression, which has particular relevance to fibrotic conditions that occur following surgery such as PCO. An interesting study was carried out by Sponer et al [144] using the human capsular bag system which demonstrated that aVb6 integrin is increased in capsular bags cultured in protein-free medium compared with cultured intact lenses. Similarly, in non-ocular fibrotic diseases aVb6 integrin is increased following acute biliary injury [145].…”

Section: Extracellular Matrix/cell Communication-integrinsmentioning

confidence: 99%

The lens as a model for fibrotic disease

Eldred

Dawes

Wormstone

2011

Phil. Trans. R. Soc. B

106

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Fibrosis affects multiple organs and is associated with hyperproliferation, cell transdifferentiation, matrix modification and contraction. It is therefore essential to discover the key drivers of fibrotic events, which in turn will facilitate the development of appropriate therapeutic strategies. The lens is an elegant experimental model to study the processes that give rise to fibrosis. The molecular and cellular organization of the lens is well defined and consequently modifications associated with fibrosis can be clearly assessed. Moreover, the avascular and non-innervated properties of the lens allow effective in vitro studies to be employed that complement in vivo systems and relate to clinical data. Using the lens as a model for fibrosis has direct relevance to millions affected by lens disorders, but also serves as a valuable experimental tool to understand fibrosis per se.

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“…While many β subunits can form heterodimers with αv, in this study the increased expression of αv in response to TGFβ is paralleled only by upregulation of the αv heterodimer partner β5 (Dawes et al, 2007). However, in a study using the human lens capsular bag model for PCO, mock cataract surgery induces expression of αvβ6 integrin (Sponer et al, 2005). It is not surprising that distinct αv integrin receptors are induced in different models of lens fibrotic disease, as most αv integrin receptors are strongly implicated in the fibrotic disease process, particularly through their activation of latent forms of TGFβ (Sheppard, 2004) and their regulation of TGFβ receptor function.…”

Section: Integrins and Lens Diseasementioning

confidence: 99%

Integrins in lens development and disease

Walker

Menko

2009

Experimental Eye Research

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Integrins are the major cell surface receptors for proteins in the extracellular matrix. These receptors form major cell signaling centers that are bidirectional, communicating messages between the cell and its environment. They are a large receptor family, with members well-known to regulate cellular processes essential to both development and disease. In this review we examine the literature regarding integrins in the lens. Here we cover integrin function in lens cell differentiation, in the development of the lens and in protection of the lens epithelial cell phenotype. In addition, we analyze the role of integrins in the progression of lens fibrotic diseases, focusing particularly on integrin regulation of TGFβ signaling pathways in Posterior Capsule Opacification (PCO) and Anterior Subcapsular Cataract (ASC).

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Upregulation of αvβ6 integrin, a potent TGF-β1 activator, and posterior capsule opacification

Abstract: Alphavbeta6 is the main activator of TGF-beta1 in the lens capsule and represents a new target for PCO prevention.

Cited by 25 publications

References 51 publications

Role of glutathione and other antioxidants in the inhibition of apoptosis and mesenchymal transition in rabbit lens epithelial cells

Role of glutathione and other antioxidants in the inhibition of apoptosis and mesenchymal transition in rabbit lens epithelial cells

The lens as a model for fibrotic disease

Integrins in lens development and disease

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