Upscaling of Plasma Processes for Carboxyl Functionalization

Sciarratta, Vincenzo; Hegemann, Dirk; Müller, Michaela; Vohrer, U.; Oehr, Christian

doi:10.1002/3527605584.ch3

Cited by 12 publications

(10 citation statements)

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“…Based on previous results26 we can affirm that the thickness of the pp‐AAc layer is approximately 400 nm. On this basis a nominal carboxylic group concentration of about 13 mmol · cm −3 can be assumed.…”

Section: Resultssupporting

confidence: 76%

“…It has to be mentioned that the produced polymer layers are stable against various solvents; they have the characteristic to be swellable and contain a high concentration of carboxylic groups 26…”

Section: Resultsmentioning

confidence: 99%

“…In the case of glass chamber slides and silicon wafers the creation of SiOH groups may enhance the adhesion of the growing films. The polymer film formation was done using a H 2 /AAc cw plasma (H 2 flow: 4 sccm, AAc flow: about 1 sccm) up to 30 min 26…”

Section: Experimental Partmentioning

confidence: 99%

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Controlled Cell Attachment, Using Plasma Deposited Polymer Microstructures: A Novel Study of Cells‐Substrate Interactions

Sciarratta

Sohn

Burger‐Kentischer

et al. 2006

Plasma Processes & Polymers

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Summary: Several actual developments in medical therapy are focussing on the potential of a surface‐dependent selection and proliferation of special cell types. For an improvement of biocompatibility it is interesting to understand the interactions between cells and material surfaces in order to create devices with the respective characteristics. In this paper the possibility to isolate three different tumor cells lines are studied: HEK293, RINm5f and KYM‐1. A procedure by means of plasma polymerization is demonstrated to create hydrophilic microstructures (precursor: AAc) on a hydrophobic (precursor: CHF3) substrate and shown to effectively select RINm5f cells. Moreover, by studying the interaction between culture media and deposited polymers, it is shown that Ca2+ ions and protein adsorption play a fundamental role in the cell‐substrate adhesion and proliferation.

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Section: Resultssupporting

confidence: 76%

Section: Resultsmentioning

confidence: 99%

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Controlled Cell Attachment, Using Plasma Deposited Polymer Microstructures: A Novel Study of Cells‐Substrate Interactions

Sciarratta

Sohn

Burger‐Kentischer

et al. 2006

Plasma Processes & Polymers

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“…Reactive plasma carboxylic functionalization using precursor molecules of the desired functionalities (e.g., acrylic acid or maleic anhydride)26, 27 are even more subject to fragmentation processes in gas (vapors) phase as a result of their interactions with the electrons and with the precursor‐derived, nascent, charged, free radicals, and neutral species; in addition to the desired functionalities, other functional groups will be simultaneously implanted onto the surfaces, reducing the specificity of the functionalization process; free radical sites (reactive surface radicals and stable, “caged” free radicals)8, 9 will initiate after plasma treatment,9, 10 non‐specific interactions with target molecules (e.g., biomolecules), which obviously will diminish significantly the molecular recognition capabilities (specificity) of the modified substrates. Possible solutions for these problems have been reported by using pulsed plasma discharges27–32 or plasma assisted macromolecules grafting 33.…”

Section: Resultsmentioning

confidence: 99%

Functionalization of Nonwoven Pet Fabrics by Water/O₂ Plasma for Biomolecule Mediated Cell Cultivation

Şaşmazel

Manolache

Gümüşderelı́oğlu

2010

Plasma Processes & Polymers

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The main target of this study was to obtain COOH functionalities on the surface of 3D, nonwoven polyethylene terephthalate fabrics (NWPFs) by using low pressure water/O2 plasma assisted treatment. The plasma treatments were performed in a cylindrical, capacitively coupled RF‐plasma‐reactor and then following steps were performed: in situ (oxalyl chloride vapors) gas/solid reaction to convert OH functionalities into COCl groups; and hydrolysis under open laboratory conditions using air moisture for finalCOOH functionalities. COOH and OH functionalities on the surfaces were detected quantitatively by fluorescent labeling techniques. The COOH‐functionalized samples were biologically activated with insulin or heparin molecules by using spacer polyoxyethylene bis‐amine (PEO). Successful immobilization was checked qualitatively using electron spectroscopy for chemical analysis (ESCA). The average amount of immobilized insulin and heparin onto NWPF surfaces were determined as 146.09 and 4.81 nmol · cm−2, respectively. Our results showed that water/O2 plasma assisted treatment worked very well for functionalization and biofunctionalization of 3D NWPF disks comparing with wet‐chemistry methods. Cell culture experiments indicated that functionalization of NWPF disks and/or nanotopographies on the disk surfaces were effective on adhesion and proliferation of L929 mouse fibroblasts.

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“…If the evaporation of reactive monomers is possible, polymerization reactions can be induced by a plasma discharge and a highly crosslinked polymer film may be deposited on materials in vicinity [232]. Depending on the monomer, substrates thus can be coated with a polymer film carrying a high density of functional groups (Fig.…”

Section: Mineralization Of Polymer Surfacesmentioning

confidence: 99%

From Sol-Gel Processing to Bio-Inspired Materials Synthesis

Löbmann

2007

CNANO

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The improvement of materials performance and their respective processing routes ever has been the driving force for material science and engineering. For the preparation of non-metallic inorganic materials the synthesis from chemical precursors is a field of steadily increasing scientific and industrial importance: Products in a broad variety of compositions can be obtained by sol-gel techniques. The shaping of intermediates allows the specific preparation of many microarchitectural configurations such as powders, fibers, thin films and aerogels. For purely inorganic products the sintering temperatures are low compared to conventional mixed-oxide ceramic processing which enables e.g. the coating of glasses and metals. Hybrid inorganic-organic compositions combine some advantages of polymers and ceramics.Nature has found amazing alternative ways to produce high-performance inorganic-organic composites at ambient temperatures under physiological conditions: Teeth, bone and nacre are self-evident examples for the capability of biomineralization processes.Even though many aspects of the related mechanisms in vivo are not yet fully understood, the utilization of the basic strategies of natural biomineralization has become a challenge to material scientist in an interdisciplinary approach.In this paper the strong points of sol-gel processing are highlighted, its limitations are discussed and related to the unique characteristics of natural biomineralization. Subsequently biomimetic and biologically-inspired material syntheses routes are reviewed which try to compensate the shortcomings of sol-gel techniques.

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Upscaling of Plasma Processes for Carboxyl Functionalization

Cited by 12 publications

References 0 publications

Controlled Cell Attachment, Using Plasma Deposited Polymer Microstructures: A Novel Study of Cells‐Substrate Interactions

Controlled Cell Attachment, Using Plasma Deposited Polymer Microstructures: A Novel Study of Cells‐Substrate Interactions

Functionalization of Nonwoven Pet Fabrics by Water/O₂ Plasma for Biomolecule Mediated Cell Cultivation

From Sol-Gel Processing to Bio-Inspired Materials Synthesis

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Upscaling of Plasma Processes for Carboxyl Functionalization

Cited by 12 publications

References 0 publications

Controlled Cell Attachment, Using Plasma Deposited Polymer Microstructures: A Novel Study of Cells‐Substrate Interactions

Controlled Cell Attachment, Using Plasma Deposited Polymer Microstructures: A Novel Study of Cells‐Substrate Interactions

Functionalization of Nonwoven Pet Fabrics by Water/O2 Plasma for Biomolecule Mediated Cell Cultivation

From Sol-Gel Processing to Bio-Inspired Materials Synthesis

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Product

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Functionalization of Nonwoven Pet Fabrics by Water/O₂ Plasma for Biomolecule Mediated Cell Cultivation