Uptake and distribution of a new SSRI, NS2381, studied by PET in living porcine brain

Smith, Donald F.; Gee, Antony D.; Hansen, Søren B.; Moldt, P.; Nielsen, Elsebet Ø.; Scheel-Krüger, Jørgen; Gjedde, Albert

doi:10.1016/s0924-977x(99)00007-3

Cited by 24 publications

(10 citation statements)

References 27 publications

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“…High concentrations of 5-HT are primarily observed in the raphe´nucleus, thalamus and basal ganglia, as in other vertebrate species (Niblock et al, 2004;Smith et al, 1999a). The serotonin receptors of mammalian brain are extremely diverse, and have not been characterized fully in the pig nervous system.…”

Section: Serotonin Systemsmentioning

confidence: 98%

The use of pigs in neuroscience: Modeling brain disorders

Lind

Moustgaard

Jelsing

et al. 2007

Neuroscience & Biobehavioral Reviews

444

407

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Section: Serotonin Systemsmentioning

confidence: 98%

The use of pigs in neuroscience: Modeling brain disorders

Lind

Moustgaard

Jelsing

et al. 2007

Neuroscience & Biobehavioral Reviews

444

407

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“…[ 11 C]NS2381 is very selective for SERT, but suffers from similar problems as many other SSRIs labelled for PET use [68]. The ratio between specific and nonspecific binding is only 1.3-1.7:1, depending on the brain region.…”

Section: Serotonin Transportermentioning

confidence: 99%

PET Studies of Brain Monoamine Transporters

Laakso

Hietala²

2000

CPD

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Monoamine transporters are proteins mainly located on nerve terminals of dopaminergic, noradrenergic and serotonergic neurons. They are members of a larger sodium dependent transporter family and represent a major mechanism terminating the action of released neurotransmitter in the synaptic cleft. In addition to being important target molecules for many antidepressive drugs and substances of abuse, transporter proteins are good markers for the integrity of monoaminergic innervation. Therefore, there is a growing interest for in vivo imaging studies using positron emission tomography (PET) or single photon emission computed tomography (SPECT) and ligands selective for monoamine transporters. In this review, the use of monoamine transporter ligands (or tracers) for imaging studies of cocaine dependence, neurodegenerative diseases and mechanism of antidepressant drug action is discussed, with special focus on the use of PET for evaluating possible new pharmacological innovations.

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“…identification of cortical and subcortical structures by modern imaging techniques such as MRI (Watanabe et al, 2001;Jelsing et al, 2005b) and positron emission tomography (Danielsen et al, 1998;Smith et al, 1999), making it possible to perform investigations of pathophysiological processes in living animals. In recent years, the pig and the Göttingen minipig have been used in preclinical investigations of, e.g.…”

Section: Introductionmentioning

confidence: 99%