Uptake and Retention of Strontium 90 in Mouse Tissues Studied by Whole Animal Autoradiography and Impulse Counting. I

Nilsson, A.; Ullberg, S.

doi:10.1177/028418516205800201

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…Here we have treated mice with '"Sr to impair NK function, an effect previously obtained with "^' Sr [1,7,14]. This impairment is likely to be caused by the radiogenic destruction of the bone marrow achieved by selective accumulation ofthe radionuclide in bone [17,19]. Although extramedullary haematopoiesis takes place in the spleen [18].…”

mentioning

confidence: 99%

Impact of ⁹⁰Sr on Mouse Natural Killer Cells and their Regulation by Alpha Interferon and Interleukin 2

et al. 1990

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Male CBA/SU mice were exposed to ionizing radiation by intraperitoneal injection of the bone-seeking beta-emitter 90Sr. NK-cell lytic activities in spleen, peripheral blood, and lymph nodes were severely depressed or completely abolished. In contrast, production of the NK regulatory proteins alpha interferon (IFN-alpha) and interleukin 2 (IL-2) was normal 5-8 weeks after 90Sr injection. IFN-alpha, produced in vivo or in vitro by cells from injected mice, was able to enhance strongly NK lytic activities. These data indicate that 90Sr acts on the bone marrow, where it interferes with the maturation and seeding of NK precursor cells. The mechanisms regulating NK activities in peripheral organs remained relatively unchanged. Finally, we did not detect any major organ redistribution of NK cells as a result of 90Sr irradiation.

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confidence: 99%

Impact of ⁹⁰Sr on Mouse Natural Killer Cells and their Regulation by Alpha Interferon and Interleukin 2

et al. 1990

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“…Similar results have been obtained with teratogens (Dencker 1976). The distribution and relative retention of ' OSr in the mothers were largely in agreement with the findings of Nilsson & Ullberg (1962) and have therefore not been described. Whereas these authors found no 90Sr in the soft tissues 4 hours after intraperitoneal injection, our results indicated that it could persist for 24 hours.…”

Section: Discussionmentioning

confidence: 53%

⁹⁰Sr in Placentas, Embryos and Foetuses of Mice, Evaluated by Whole‐Body Autoradiography

Olsen

Jonsen

1979

Acta Pharmacologica et Toxicologica

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90Sr is a hazardous fission product from nuclear reactions. Its transplacental passage is of particular interest because of the high sensitivity of embryos/foetuses to ionizing radiation. We have used whole-body autoradiography to study the foetal uptake and retention of 90Sr and the embryonic/foetal transfer of this isotope as a function of gestational age. Fifteen minutes after an intraperitoneal injection of 50 p i 9oSr-nitrate into a 14-day-pregnant mouse, radioactivity was present in the placenta, but not in the foetus. During a 72-hour observation period, 90Sr gradually accumulated in the hard foetal tissues. In the soft foetal tissues, accumulation occurred up to 12-24 hours. After 72 hours, no 90Sr could be detected in the soft tissues. 90Sr crossed the visceral yolk sac placenta during early gestation, the visceral yolk sac and the chorioallantoic placentas during late gestation. Transfer increased considerably at the end of the latter period. There was a marked uptake of 90Sr in all structures of early embryos, whereas the isotope concentrated in the preskeletal and skeletal parts of the foetuses. Intake of 90Sr during early gestation may therefore be more injurious to the offspring than intake during late gestation.

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“…It was designed to supplement those studies by providing a link between epidemiologic studies of radium effects in humans, and studies in dogs with various radionuclides for which few effects have been documented in humans. Dogs injected between 1954 and1963;last dog died in 1977; analysis is complete. Single intravenous injection of radium citrate solution.…”

Section: Long-term Animal Studies In Radiobiologymentioning

confidence: 99%

International radiobiology archives of long-term animal studies. I. Descriptions of participating institutions and studies

Gerber¹,

Watson²,

Sugahara³

et al. 1996

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Uptake and Retention of Strontium 90 in Mouse Tissues Studied by Whole Animal Autoradiography and Impulse Counting. I

Cited by 5 publications

References 6 publications

Impact of ⁹⁰Sr on Mouse Natural Killer Cells and their Regulation by Alpha Interferon and Interleukin 2

Impact of ⁹⁰Sr on Mouse Natural Killer Cells and their Regulation by Alpha Interferon and Interleukin 2

⁹⁰Sr in Placentas, Embryos and Foetuses of Mice, Evaluated by Whole‐Body Autoradiography

International radiobiology archives of long-term animal studies. I. Descriptions of participating institutions and studies

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Uptake and Retention of Strontium 90 in Mouse Tissues Studied by Whole Animal Autoradiography and Impulse Counting. I

Cited by 5 publications

References 6 publications

Impact of 90Sr on Mouse Natural Killer Cells and their Regulation by Alpha Interferon and Interleukin 2

Impact of 90Sr on Mouse Natural Killer Cells and their Regulation by Alpha Interferon and Interleukin 2

90Sr in Placentas, Embryos and Foetuses of Mice, Evaluated by Whole‐Body Autoradiography

International radiobiology archives of long-term animal studies. I. Descriptions of participating institutions and studies

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Product

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Impact of ⁹⁰Sr on Mouse Natural Killer Cells and their Regulation by Alpha Interferon and Interleukin 2

Impact of ⁹⁰Sr on Mouse Natural Killer Cells and their Regulation by Alpha Interferon and Interleukin 2

⁹⁰Sr in Placentas, Embryos and Foetuses of Mice, Evaluated by Whole‐Body Autoradiography