Uptake by breast carcinoma of a lipidic nanoemulsion after intralesional injection into the patients: A new strategy for neoadjuvant chemotherapy

Mendes, Sérgio; Graziani, Silvia Regina; Vitório, Tatiana Solano; Padoveze, Amanda Felippe; Hegg, Roberto; Bydlowski, Sérgio Paulo; Maranhão, Raul C.

doi:10.1016/j.ygyno.2008.10.018

Cited by 26 publications

(18 citation statements)

References 21 publications

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“…In a previous study, we had shown that the intralesional injection of the nanoemulsion into breast carcinoma tissue resulted in a great concentration of LDE in the tumor. 28 Likewise, the tropism of LDE for the inflamed synovial tissues was shown in the present experiment, whereby the injected radioactively labeled LDE was 2.5 times more concentrated in the arthritic joint than in the normal joint.…”

Section: Discussionsupporting

confidence: 76%

Intra-articular methotrexate associated to lipid nanoemulsions: anti-inflammatory effect upon antigen-induced arthritis

Mello¹,

Tavares²,

Bulgarelli³

et al. 2013

IJN

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Section: Discussionsupporting

confidence: 76%

Intra-articular methotrexate associated to lipid nanoemulsions: anti-inflammatory effect upon antigen-induced arthritis

Mello¹,

Tavares²,

Bulgarelli³

et al. 2013

IJN

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“…Treatments such as solid lipid nanoparticles [7], chitosan nanoparticles [8] and albumin microspheres [9] were used with varying degrees of success. A recent clinical study by Mendes et al [10] strongly favors the intratumoral route over an intravenous route as a method of concentrating the injected lipidic nanoemulsion in the breast carcinoma tissue.…”

Section: Introductionmentioning

confidence: 99%

Effective antitumor activity of paclitaxel-loaded poly (ε-caprolactone)/pluronic F68 nanoparticles after intratumoral delivery into the murine breast cancer model

Ma¹,

Yang²,

Zhang³

et al. 2010

Anti-Cancer Drugs

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A paclitaxel-loaded poly (epsilon]-caprolactone)(PCL)/pluronic F68 (F68) nanoparticle formulation was prepared as an intratumoral delivery system to assess its potential for future neoadjuvant chemotherapy application in the treatment of breast cancer. Paclitaxel-loaded nanoparticles were prepared by a solvent evaporation method using the self-synthesized PCL/F68 compound. Prepared nanoparticles were spherical with a rough, porous surface. As described in our earlier study, F68 was incorporated into the PCL matrix as both a pore-forming agent and to enhance drug release from the particles. A murine breast cancer model has shown that when using equivalent paclitaxel doses, paclitaxel-loaded PCL/F68 nanoparticles administered by a single intratumoral injection were more efficient in impeding tumor development than conventional paclitaxel injections administered by multiple intraperitoneal injections. In conclusion, paclitaxel-loaded PCL/F68 nanoparticles can be delivered intratumorally and they effectively prevent tumor cell growth and establishment in a localized area. This treatment shows promise as a future neoadjuvant chemotherapy application in the treatment of breast cancer.

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“…Mendes and his team have recently shown that lecoregional injection of lipid nanoemulsion concentrates more in breast carcinoma minimizing interaction with the healthy cells. Therefore, it can be a promising approach for drugtargeting in neoadjuvant chemotherapy in breast cancer treatment (10) . Hyun-Jong Choc and co-workers observed that a novel lipid nanoemulsion system could improve permeation of granisetron.…”

Section: Recent Trend In Nanoemulsionsmentioning

confidence: 99%

“…(2,9) . It can bring a great revolution in cancer treatment since it was always a difficult measure to destroy the cancer cells completely with minimal interference to the normal body cells (10) . This compilation, illustrating the manufacturing methods as well as the recent researches, portrays the rising possibilities of nanoemulsions to serve the human being accurately with minimum damage.…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsions: increasing possibilities in drug delivery

Sutradhar

Amin

2013

European Journal of Nanomedicine

174

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Nanotechnology, the science of nano sized particles, has rapidly gained the spotlight in diversified areas including pharmaceutical sector. With the blessings of accurate drug designing and better pharmacological action, it has entered the pharmaceutical arena bringing promising discoveries along with it. Nanoemulsion is one of the greatest and advantageous dosage forms with the application of nanotechnology in pharmaceutical formulations. Very small size droplets of the nanoemulsion favor better drug absorption and targeting. It not only improves the conventional emulsion systems but also opens new opportunities for other drugs to be designed more precisely with better bioavailability and accurate dosing rendering minimum side effects. This article depicts various advantageous features of nanoemulsions delineating different methods of preparation. The foci of this review also include the opportunities of other drugs to be formulated through nanoemulsification in order to ensure better therapeutic effect. The summary shows recent researches on nanoemulsion formulation from different classes of drugs as well as some formulations based on nanoemulsion templates. The methods of preparing nanoparticles, characterized by nanoemulsion templates, have also been discussed which, as a whole, presents the best possibilities of nanoemulsions.

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Uptake by breast carcinoma of a lipidic nanoemulsion after intralesional injection into the patients: A new strategy for neoadjuvant chemotherapy

Cited by 26 publications

References 21 publications

Intra-articular methotrexate associated to lipid nanoemulsions: anti-inflammatory effect upon antigen-induced arthritis

Intra-articular methotrexate associated to lipid nanoemulsions: anti-inflammatory effect upon antigen-induced arthritis

Effective antitumor activity of paclitaxel-loaded poly (ε-caprolactone)/pluronic F68 nanoparticles after intratumoral delivery into the murine breast cancer model

Nanoemulsions: increasing possibilities in drug delivery

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