Uptake, Distribution and Release of 14C-Triclosan in Human Gingival Fibroblasts

Mustafa, Manal; Wondimu, Biniyam; Hultenby, Kjell; Yucel‐Lindberg, Tülay; Modéer, Thomas

doi:10.1002/jps.10429

Cited by 13 publications

(6 citation statements)

References 16 publications

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“…Of note, studies to discern the subcellular localization of TCS show preference for nuclear, as opposed to cytosolic, accumulation. Although initial uptake was considerably higher in the cytoplasm, a great proportion of cytosolic TCS was eliminated after repeated washing, while nuclear retention was observed [143]. This may explain the perturbed inflammatory signaling associated with TCS.…”

Section: Immunity and Inflammationmentioning

confidence: 99%

Triclosan: An Update on Biochemical and Molecular Mechanisms

Alfhili

Lee

2019

Oxidative Medicine and Cellular Longevity

102

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Triclosan (TCS) is a synthetic, chlorinated phenolic antimicrobial agent commonly used in commercial and healthcare products. Items made with TCS include soaps, deodorants, shampoos, cosmetics, textiles, plastics, surgical sutures, and prosthetics. A wealth of information obtained from in vitro and in vivo studies has demonstrated the therapeutic effects of TCS, particularly against inflammatory skin conditions. Nevertheless, extensive investigations on the molecular aspects of TCS action have identified numerous adversaries associated with the disinfectant including oxidative injury and influence of physiological lifespan and longevity. This review presents a summary of the biochemical alterations pertaining to TCS exposure, with special emphasis on the diverse molecular pathways responsive to TCS that have been elucidated during the present decade.

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Section: Immunity and Inflammationmentioning

confidence: 99%

Triclosan: An Update on Biochemical and Molecular Mechanisms

Alfhili

Lee

2019

Oxidative Medicine and Cellular Longevity

102

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“…Cells were treated for 12 hours with the indicated agents and then harvested for CAT activity. This was measured as picomoles chloramphenicol butyrylated per hour per milligrams protein, 22 which is noted on the y ‐axis. n = 3.…”

Section: Resultsmentioning

confidence: 99%

Triclosan Blocks MMP‐13 Expression in Hormone‐Stimulated Osteoblasts

Barnes

Shimizu

et al. 2013

Journal of Periodontology

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Background Matrix metalloproteinase-13 (Mmp-13) is an important enzyme for the modulation of bone turnover and gingival recession. Elevated levels of Mmp-13 are associated with alveolar bone resorption, periodontal ligament destruction, and gingival attachment loss, which are the clinical symptoms of periodontal disease. Continued evidence suggests periodontal disease contributes to oral tissue destruction and is linked to numerous systemic conditions. Triclosan is a long standing, proven antibacterial and anti-inflammatory agent found in the only FDA-approved dentifrice for the treatment of plaque and gingivitis. Methods This study examined the inhibitory effects of triclosan on lipopolysaccharide (LPS), parathyroid hormone (PTH) and prostaglandin E2 (PGE2) induced expression of Mmp-13 in UMR 106-01 cells, an osteoblastic osteosarcoma cell line. The cells were stimulated with PTH or PGE2 to induce Mmp-13 mRNA expression and Real Time RT-PCR was performed to determine gene expression levels. Western blot analysis assessed the presence or absence of protein degradation or inhibition of protein synthesis. Mmp-13 Promoter Reporter Assay was utilized to explore possible direct effects of triclosan on the Mmp-13 promoter. Results Triclosan significantly reduced PTH or PGE2 elevated expression of Mmp-13 in osteoblastic cells without affecting basal levels of the mRNA. Surprisingly, triclosan enhanced the expression of c-fos and amphiregulin mRNA. A promoter assay indicated triclosan directly inhibits the activation of the PTH-responsive minimal promoter of Mmp-13. Conclusion Our data appear to have identified a nuclear mechanism of action of triclosan which accounts for triclosan’s ability to inhibit PTH or PGE2 induced Mmp-13 expression in osteoblastic cells.

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“…89 Nevertheless, worth noting is that a certain quantity of these compounds may be persistent due to their bioaccumulation property and continual infusion, in spite of the low level of PPCPs observed in a short time. 90 Adults appear not to be significantly impacted by short-term acute exposure to PPCPs/EDCs (endocrine disrupting compounds) in foods, whereas long-term chronic exposure even at extremely low concentrations might be harmful. Furthermore, PPCPs like triclosan have been found in human plasma and milk, suggesting a potential risk to infants during lactation.…”

Section: Uncertainty Of Agriculturally Derived Ppcp Risks To Human Hementioning

confidence: 98%

The Fate and Impact of Pharmaceuticals and Personal Care Products in Agricultural Soils Irrigated With Reclaimed Water

Qin

Chen

Zhuang

2014

Critical Reviews in Environmental Science and Technology

101

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Reclaimed water is an important source of irrigation and is widely used on agricultural soils throughout the world, particularly in arid and semi-arid regions. However, concerns about the potential risks of this practice are rapidly increasing because reclaimed water may contain various organic pollutants such as pharmaceuticals and personal care products (PPCPs). Trace levels of PPCPs have been found in fields irrigated with reclaimed water, and continual infusion, along with bioaccumulation properties, may result in significant bio-uptake and PPCP contamination in agricultural soils. This review attempts to summarize the literature concerning the fate and behavior of PPCPs in agricultural soils, as well as their adverse effects on soil organisms (including microorganisms and fauna), crops, and even humans via dietary consumption. Strategies and potential technologies for degrading or removing PPCPs from soils are addressed, along with the irrigation strategies and agricultural practices for minimizing PPCP transfer to crops and groundwater. Based on this review, we conclude that the agricultural risks of PPCPs associated with reclaimed water irrigation could be controlled under certain agro-ecological conditions. We suggest developing agro-ecosystem specific practices and regulations for reclaimed water irrigation on the basis of a systematic assessment and modeling analysis of the fate, transport, accumulation, and transformation of PPCPs in soil-crop systems.

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Uptake, Distribution and Release of 14C-Triclosan in Human Gingival Fibroblasts

Cited by 13 publications

References 16 publications

Triclosan: An Update on Biochemical and Molecular Mechanisms

Triclosan: An Update on Biochemical and Molecular Mechanisms

Triclosan Blocks MMP‐13 Expression in Hormone‐Stimulated Osteoblasts

The Fate and Impact of Pharmaceuticals and Personal Care Products in Agricultural Soils Irrigated With Reclaimed Water

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