Uptake of arachidonic acid, arachidic acid, oleic acid and their incorporation into phospholipids and triacylglycerols of isolated murine hepatocytes. Effect of thrombin-antithrombin III complex

Biocompatible Slippery Fluid-Infused Films Composed of Chitosan and Alginate via Layer-by-Layer Self-Assembly and Their Antithrombogenicity

“…The biocompatible SLIPS demonstrated significant antithrombogenicity caused by its low surface wettability and the anticoagulation property of almond oil, whose main component is oleic acid. Oleic acid enhances the antithrombin activity of the film by binding to lysine residues near the N-terminus of antithrombin III, which is a physiological serine protease inhibitor that controls the coagulation reaction as a blood clotting inhibitor and promotes reactions with the serine proteolytic enzymes . Linoleic acid, another major component of almond oil, is incorporated into lipoprotein lipids and demonstrates an antiatherogenic effect.…”

“…Oleic acid enhances the antithrombin activity of the film by binding to lysine residues near the N-terminus of antithrombin III, which is a physiological serine protease inhibitor that controls the coagulation reaction as a blood clotting inhibitor and promotes reactions with the serine proteolytic enzymes. 59 Linoleic acid, another major component of almond oil, is incorporated into lipoprotein lipids and demonstrates an antiatherogenic effect. The enrichment of lipoprotein particles with less oleic acid at the expense of linoleic acid increases their resistance to oxidative stress because of the increased susceptibility to oxidation of lipoproteins enriched with linoleic acid, reducing platelet activity.…”

Facile design of plant-oil-infused fine surface asperity for transparent blood-repelling endoscope lens

“…42,43 This chemical anticoagulation potential exhibited by the SLIPS was due to the presence of oleic acid in the plant oil. 28,44 The oleic acid bound the blood lysine, which is responsible for coagulation, as well as antithrombin III, which functions as an anticoagulant. The overall coagulation reaction was thus controlled.…”

“…The overall coagulation reaction was thus controlled. 44 For endoscope lens, our coating prevents blood clotting for 20 minutes that is enough for practical use because blood slides on coating immediately.…”