2002
DOI: 10.2116/analsci.18.273
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Uptake of Transition Metal Ions Using Liposomes Containing Dicetylphosphate as a Ligand

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Cited by 4 publications
(4 citation statements)
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“…It is now well established that divalent metals can, even in the absence of a pH gradient, facilitate the encapsulation of selected anticancer drugs with chemical groups capable of forming coordination complexes with transition metals trapped inside liposomal vesicles (3,6,7,(13)(14)(15)(16)(17). When assessing the role of transmembrane pH gradients on this loading process, our research suggested that copper exhibited a distinct advantage over manganese (another metal commonly employed to facilitate encapsulation), in terms drug retention (6,10,17).…”
Section: Introductionmentioning
confidence: 76%
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“…It is now well established that divalent metals can, even in the absence of a pH gradient, facilitate the encapsulation of selected anticancer drugs with chemical groups capable of forming coordination complexes with transition metals trapped inside liposomal vesicles (3,6,7,(13)(14)(15)(16)(17). When assessing the role of transmembrane pH gradients on this loading process, our research suggested that copper exhibited a distinct advantage over manganese (another metal commonly employed to facilitate encapsulation), in terms drug retention (6,10,17).…”
Section: Introductionmentioning
confidence: 76%
“…Although interaction of copper with camptothecins has been previously documented (26,32), a recent report completed using copper gluconate demonstrated no direct interaction between copper and irinotecan (3), although it should be noted that this formulation maintains an internal pH that is >6.5. As noted above, it has been reported that copper can bind to phospholipids (16,29), and it could be argued that the copper-lipid interaction may affect membrane permeability in a more generic way. For this reason, we assessed the influence that copper has on membrane permeability as determined using sucrose as a membrane permeable marker.…”
Section: Influence Of Entrapped Copper Concentration On Drug Retentionmentioning
confidence: 94%
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“…Multilamellar vesicules of phosphatidylcholine liposomes in egg yolk and cholesterol exhibit a high affinity of Cu 2+ ions to diacetylphosphate [65]. It was demonstrated that the behavior of copper compounds in hydrophobic micellar systems is determined primarily by the solvent [66].…”
mentioning
confidence: 99%