Uptake, Tissue Distribution, and Depuration of Cadmium (Cd) in the Frog Rana ridibunda

Vogiatzis, Angelos K.; Loumbourdis, N. S.

doi:10.1007/s001289900547

Cited by 46 publications

(12 citation statements)

References 15 publications

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“…Adult toads of the same size and almost the same weight (32.87g±0.03) were acclimatized in glass tanks (51¥32¥33 cm) containing 2 L of dechlorinated tap water, for 7 days prior to the experiments. 18 Tanks were placed on a slant to provide the option of both aqueous and dry environment. 17 Water was changed every 2 days and the tank cleaned thoroughly.…”

Section: Collection Of Test Organismsmentioning

confidence: 99%

Diazinon mediated biochemical changes in the African toad (Bufo regularis)

Tongo¹,

Ezemonye²,

Ochei

2012

J Xenobiotics

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The sublethal toxicity of diazinon to the adult African toad, Bufo regularis was assessed using an integration of biomarkers. Changes in acetylcholinesterase (AChE), corticosterone and total protein levels were assessed in the serum, brain, liver, lungs and gastrointestinal tract (GIT) and the results supported by bioaccumulation data. The biomarkers were chosen as indicators of key physiological functions: AChE for neurotoxicity, corticosterone and total protein levels as indicators of oxidative stress. Toads were exposed to 0.01, 0.02, 0.03 and 0.04 g/L for 28 days. Brain AChE activity reduced by 96% in the highest concentration (0.04 g/L) compared to the control brain. Similarly, AChE activities in serum, liver, lungs and GIT tissues (88%, 88%, 87, 87% umg -1 protein respectively) were also inhibited in the toads. Corticosterone and total protein levels in the tissues decreased compared to the control. The accumulation results obtained showed accumulation in the tissues (liver>serum>brain> lung>GIT), with a direct relationship between tissue concentration and changes in the biochemical indices. The alterations in all the indices were significantly concentration dependent. The biomarkers described in this study could be useful complementary indices in the risk assessment of diazinon pesticide.

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Section: Collection Of Test Organismsmentioning

confidence: 99%

Diazinon mediated biochemical changes in the African toad (Bufo regularis)

Tongo¹,

Ezemonye²,

Ochei

2012

J Xenobiotics

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“…Furthermore, cadmium has been reported to inhibit a variety of thiol-containing enzymes which include γ-glutamyl cysteine, the rate limiting enzyme in the biosynthesis of GSH (Jinna et al, 1989). Rana ridibunda exposed to cadmium (534 ppm) for 4, 10 and 30 days showed a decrease in GSH concentration following a time-and Cd concentration dependent pattern (Volgiatzis and Loumbourdis, 1997).…”

Section: Discussionmentioning

confidence: 93%

“…It is very toxic to aquatic and terrestrial biota. Cadmium is introduced into the aquatic environment primarily by human activities including mining, fertilizer application and industrial discharges (James and Little, 2003;Ezemonye and Enuneku, 2005;Volgiatzis and Loumbourdis, 1997).…”

Section: Introductionmentioning

confidence: 99%

Untitled

L.I.N.¹,

A.A.²

2011

Turk. J. Fish. Aquat. Sci.

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The adult crowned bullfrog, Hoplobatrachus occipitalis was exposed to 0.25, 0.50, 1.00 and 2.00 mg/L cadmium for 28 days. The effect of cadmium on selected biochemical parameters-superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) in the liver were tested. Biochemical observations revealed significant (P<0.05) dose-dependent increase in the specific activity of superoxide dismutase (SOD) and catalase (CAT) relative to controls. This could be due to increased production of these antioxidants to counteract oxidative stress and lipid peroxidation induced by cadmium. Glutathione (GSH) level decreased with increase in the concentration of heavy metal. Thiobarbituric acid reactive substances (TBARS) which is an index of lipid peroxidation increased as concentration of cadmium increased. The increased level of TBARS in the liver of cadmium exposed frogs is an indication of increased membrane lipid peroxidation which could lead to cell damage.

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“…Liver is one of the target organs of Cd bioaccumulation in R. ridibunda and it is a phenomenon that has already been observed and discussed in other articles related to Cd e!ects (Vogiatzis and Loumbourdis 1997.…”

Section: Discussionmentioning

confidence: 93%