Ural cohort of the population exposed in childhood

Шалагинов, С. А.; Крестинина, Л. Ю.

doi:10.21514/1998-426x-2020-13-1-91-93

Radiac. gig. (2008)

2020

DOI: 10.21514/1998-426x-2020-13-1-91-93

|View full text |Cite

Ural cohort of the population exposed in childhood

С. А. Шалагинов¹,

Л. Ю. Крестинина²

Abstract: The object of the study is the cohort of individuals exposed in the Southern Urals in the 1950s at the age of 0–19 years. The relevance of the creation of the cohort of individuals exposed in childhood and adolescence is determined by their high sensitivity to radiation exposure and is associated with the need for differentiated assessments of the radiation risk of morbidity and mortality for individuals exposed at different stages of ontogenesis. The work includes definition of the cohort, the criteria for in… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2021

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Radiogenic risk of solid cancer incidence in persons exposed to radiation in childhood in the Southern Urals

Krestinina

Шалагинов

Силкин

et al. 2021

Radiac. gig. (2008)

View full text Add to dashboard Cite

The aim of this work is to assess the radiogenic risk of solid cancers incidence in the members of the Urals Childhood Exposure Cohort. The cohort includes people exposed under 20 years of age as a result of two radiation accidents at the Mayak Production Association in the Southern Urals (discharges of radioactive waste into the Techa River and the formation of the East Ural radioactive trace). The number of the cohort for solid cancer incidence analysis is 31,578 individuals. All the members were postnatally exposed and some of them – in-utero. Some of their parents were exposed before conception. 2,018 solid cancers were registered on the incidence catchment area during the period 1956-2018, the total amount of person years was 818,083. The analysis was carried out by the Poisson regression method with a simple parametric excess relative risk model. 95% confidence intervals were estimated with maximum likelihood approach. Only a postnatal dose was used in the first solid cancer incidence analysis of this cohort members with due account for preconception exposure of parents. TRDS-2016 mean postnatal dose accumulated over the entire follow-up period in the stomach of cohort members was 0.047 Gy. The analysis showed linear dependence of solid cancer incidence excess relative risk on postnatal dose. Excess relative risk was 0.66/Gy, р=0.006 with a five-year latency period. While estimating excess relative risk in different age groups at the beginning of exposure, a significant risk was present only in the age group under 1 year and amounted to 2.16/Gy; р<0.02 at the onset of exposure. The present results are in agreement with the results of the solid cancer incidence risk analysis both in the Techa River Cohort of exposed In-Utero where a statistically significant excess relative risk from a postnatal dose was revealed, and with the results of risk analysis in the Japanese cohort of people exposed in-utero and in early childhood.

show abstract

Radiogenic risk of solid cancer incidence in persons exposed to radiation in childhood in the Southern Urals

Krestinina

Шалагинов

Силкин

et al. 2021

Radiac. gig. (2008)

View full text Add to dashboard Cite

show abstract

Solid cancer mortality risk in the cohort of Urals population exposed to radiation for up the age of 20

Silkin,

Krestinina

2024

Radiac. gig. (2008)

View full text Add to dashboard Cite

The objective of the current study is the direct assessment of the excess relative risk of solid cancer mortality in people affected by low dose-rate chronic exposure mainly in low-to medium dose range (up to 1 Gy) at the age of <20. The study cohort consists of the population exposed at the age of <20 as a result of two large radiation accidents at the “Mayak” Production Association. The size of the cohort is 32,762 persons, follow-up period – 71 years (from 1950 through 2020), the number of person-years at risk is – 1 218 855. For this cohort the mortality catchment area includes Chelyabinsk and Kurgan Oblasts. Over a 71-year follow-up period 1,788 solid cancer deaths were registered in the cohort. Mean dose accumulated in the stomach walls over the whole follow-up period was 0.04 Gy, maximum dose was 1.1 Gy. Statistical processing of data was performed using Amfit and Datab software packages (Epicure statistics software package). Solid cancer mortality risk was analyzed with the Poisson regression using simple parametric excess relative risk model. Statistical significance of the results was estimated using the maximum likelihood method with 95% probability. For the first time the direct assessments of the excess relative risk of solid cancer mortality have been obtained in the Urals Cohort of population exposed at age <20 for a 71-year period (Excess Relative Risk was 0.84/Gy, 95% confidence interval: 0.24-1.55 for 10-years minimal latency period and 0.83 (0.24-1.55) for 5-year minimal latency period). Statistically significant estimates of the excess relative risk have been obtained for specific groups within the cohort selected according to the sex, age at the onset of exposure, and Oblast of residence at the time of exposure.

show abstract

Incidence of mental disorders in the population of municipal areas of the Сhelyabinsk region in the remote period after accidental radioactive contamination

Буртовая

Akleyev

Barkovskaia³

et al. 2021

Med.-biol. soc.-psihol. probl. bezop. črezvyčajnyh situac.

View full text Add to dashboard Cite

Relevance. Both Russian and foreign researchers pay attention to the mental disorders in people with a history of accidental radiation exposure. A wide range of mental pathologies have been observed among the Chernobyl NPP clean-up workers, victims of the accident at the Fukushima Daiichi NPP, etc.Intention – To assess primary incidence of mental disorders and behavioral disorders in residents of the municipal areas of the Chelyabinsk region affected by radioactive contamination.Methodology. Primary incidence rates of mental disorders and behavioral disorders (F00–09, F20–99 ICD-10) were assessed for the period from 2005 to 2018 in residents of municipal areas of the Chelyabinsk regions (Kunashaksky, Krasnoarmeysky, Argayashsky, Kaslinsky, Sosnovsky districts) affected by radioactive contamination in 1949–1951 and 1957 as a result of the activities of the “Mayak” production association. These data were compared to that from non-contaminated Etkulsky district with similar population and economic activity. Mental disorders were classified according to the groups of the chapter V “Mental and behavioral disorders” of the International Classification of Diseases of the 10th revision (ICD-10). Incidence was calculated per 10 thousand population (0/000). Descriptive analysis of the registered primary incidence of mental disorders in residents of these districts of the Chelyabinsk region is presented.Results and discussion. The primary incidence rate of mental disorders in the Chelyabinsk region (49.1 ± 3.6) 0/000 significantly (p < 0.001) exceeds those in the Sverdlovsk (30.3 ± 4.2), Kurgan (30.2 ± 6.9) 0/000 regions and overall estimates for the Russian Federation (32.9 ± 3.8) 0/000 . In the remote period, primary incidence rates of mental disorders in the residents of some radioactively contaminated districts were higher vs Etkulsky district, but significantly lower than overall rates in the Chelyabinsk region (p < 0.001). Taking into account the territorial distribution of the exposed residents and their offspring in the Chelyabinsk region, mental retardation in residents of the Kunashak district should be closely monitored.Conclusion. Mental morbidity in areas accidentally contaminated more than 70 years ago now reflects the general trend of deterioration in the mental health of the population of the Chelyabinsk region. It can be assumed that the incidence of mental disorders in the population of the Chelyabinsk region is determined by a constellation of interacting factors (socio-economic, personal-psychological, radiation, informational and others), among which socially determined mechanisms of the mental pathology prevail.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Ural cohort of the population exposed in childhood

Cited by 3 publications

References 0 publications

Radiogenic risk of solid cancer incidence in persons exposed to radiation in childhood in the Southern Urals

Radiogenic risk of solid cancer incidence in persons exposed to radiation in childhood in the Southern Urals

Solid cancer mortality risk in the cohort of Urals population exposed to radiation for up the age of 20

Incidence of mental disorders in the population of municipal areas of the Сhelyabinsk region in the remote period after accidental radioactive contamination

Contact Info

Product

Resources

About