Urates in Exhaled Breath Condensate of Children With Asthma: Table 1

Dodig, Slavica; Čepelak, Ivana; Vlašić, Željka; Topić, Renata Zrinski; S, Banovic

doi:10.1309/lmta9ze2rz4usknp

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…The fa ct that EBC ura tes (but not se rum ura tes) in children wi th OSA we re hig her than in cli ni cal ly heal-thy chil dren ad di tio nal ly con fi r ms lo cal synthe sis of uric acid in the ai rways. In our pre vious in ves tiga tion ele va ted con cen tra tion of ura tes in EBC of chil dren wi th con trol led as thma [63 (38-111) μmol/L] was fou nd (19). EBC con cen tra tion of urates was un mea su rab le (i.e.…”

Section: Discussionmentioning

confidence: 79%

“…It see ms that an in crea se of ura te concen tra tion fol lows (20) the ini tial ura te dep le tion (21), con fi r mi ng lo cal synthe sis of uric acid. To our knowled ge, be si des our in ves ti ga tion (19) the re are no stu dies that ha ve in ves ti ga ted uric acid, as a mar ker of oxi da ti ve stre ss, in EBC. Also, we ha ve fou nd on ly two stu dies by Gol dba rt et al (22) and Li et al (23) re gar di ng EBC in chil dren and adul ts, res pec ti ve ly, wi th OSA.…”

Section: Discussionmentioning

confidence: 88%

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Urates in exhaled breath condensate of children with obstructive sleep apnea

Vlašić¹,

Trifunovic²,

Čepelak

et al. 2011

Biochem Med

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Bac kgrou nd: Ura te le ve ls may be a mar ker of oxi da ti ve stre ss. The aim of the pre se nt stu dy was to fi nd out are the re any diff e ren ces in ura te concen tra tio ns in exha led brea th con den sa te (EBC) be tween chil dren wi th obstruc ti ve sleep ap nea (OSA) and heal thy chil dren. Ma te ria ls and met ho ds: EBC was col lec ted in chil dren wi th ob struc ti ve sleep ap nea (OSA) and cli ni cal ly heal thy chil dren. Ura te mea su re men ts in EBC and se rum we re per for med by en zyma tic co lor te st. Re sul ts: The hig her con cen tra tion of ura tes in EBC of chil dren wi th OSA than cli ni cal ly heal thy chil dren in di ca te the oxi da ti ve stre ss in their ai rways. Sin ce the re was no sig ni fi ca nt diff e ren ce in se rum con cen tra tion of ura tes be tween chil dren wi th OSA and heal thy chil dren, it cou ld be con si de red that ura tes are sin te ti zed in the ai rways of chil dren wi th OSA. Con clu sio ns: The pre se nt stu dy in di ca ted that ura tes in EBC (but not in se rum) may be used as a mar ker of lo cal synthe sis of an tioxi da nt com pounds, but de fi ni ti ve con clu sion mu st be sup por ted by in ves ti ga tio ns in vol vi ng lar ger num ber of par ti ci pan ts.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 88%

Urates in exhaled breath condensate of children with obstructive sleep apnea

Vlašić¹,

Trifunovic²,

Čepelak

et al. 2011

Biochem Med

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“…However, we found a low to moderate correlation between frequency of asthma symptoms and local inflammation presented with EBT. EBC urates are proposed as a new non-invasive biomarker of altered oxidative-antioxidative balance in exhaled breath in asthmatics [23]. They are decreased in uncontrolled asthmatics [24] possible due to their consumption during increased oxidative stress in uncontrolled asthma.…”

Section: Discussionmentioning

confidence: 99%

Association of Asthma Symptoms and Exacerbation with Inflammatory Biomarkers

Navratil¹,

Jureković²,

Topalušić³

et al. 2017

Clin Pediatr OA

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Objective: To investigate a relationship of asthma symptoms and exacerbations with systemic (high-sensitivity Creactive protein (hs-CRP), eosinophilic cationic protein (ECP), leukocytes) and local (exhaled NO (FENO), pH and urates in exhaled breath condensate (EBC) and exhaled breath temperature (EBT)) inflammatory biomarkers (BMs) in asthmatic children. Methods:This cross-sectional study comprised 93 consecutive asthmatic patients (age 6-18 years, 22 girls) with mild intermittent asthma ([IA], N=44) and mild to moderate persistent asthma ([PA], N=49). Medical history (asthma symptoms and exacerbation), pulmonary function, FENO, EBT, samples of exhaled breath and peripheral blood were collected.Results: Local BMs (EBC urates and EBT) showed stronger correlation with asthma symptoms then systemic BMs (hs-CRP, blood count with differencials) (r=0.26-0.68, r=0.06-0.32, p<0.05; respectively). Single measurements of inflammatory BMs are not good predictors for future asthma exacerbation (binary logistic regression; χ²=13.9; df=11; p=0.238). Conclusion:Study of combination of various exhaled breath and exhaled breath condensate BMs should continue, especially in longitudinal studies with repeated measurements of BMs.

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“…Values of EBC constituents have been extensively investigated in healthy subjects as well as in patients with respiratory diseases, since these diseases are associated with alterations of the RTLF composition ( 59 ). The majority of investigations refer to H 2 O 2 ( 2 , 3 , 17 , 59 ), pH ( 2 , 3 , 19 , 30 , 61 ), nitric oxide (NO) ( 2 , 3 , 19 ) and its metabolites ( 2 , 3 , 62 , 63 ), purines ( 3 , 64 , 65 ), various eicosanoides (prostanoides, leukotrienes) ( 2 , 3 , 66 ) and proteins (interleukins, cytokines, cytokeratins) ( 42 , 67 ), electrolytes ( 68 ), urates ( 69 ). Special issue is referred on mebolomics, i.e.…”

Section: Post-analytical Phasementioning

confidence: 99%

“…A number of investigations study the changes of biomarkers in different pulmonary diseases ( Table 1 , Table 4 ). The list of states and diseases for which EBC analysis is used include asthma ( 2 , 3 , 17 , 44 , 69 , 73 , 74 , 77 , 89 , 90 , 95 ), COPD ( 2 , 3 , 42 , 47 , 54 , 71 – 73 , 77 , 83 , 86 , 96 ), gastroesophageal reflux disease (GERD) ( 2 , 3 , 45 ), obstructive sleep apnea (OSA) ( 80 , 94 ), pulmonary fibrosis ( 81 ), pneumonia ( 4 , 17 ), cystic fibrosis ( 7 , 17 , 76 , 92 ), adult respiratory distress syndrome (ARDS) ( 3 , 17 , 93 ), non-respiratory diseases ( 82 , 84 ) ( Table 1 ).…”

Section: Post-analytical Phasementioning

confidence: 99%

Exhaled breath condensate – from an analytical point of view

Dodig

Čepelak

2013

Biochem Med

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Over the past three decades, the goal of many researchers is analysis of exhaled breath condensate (EBC) as noninvasively obtained sample. A total quality in laboratory diagnostic processes in EBC analysis was investigated: pre-analytical (formation, collection, storage of EBC), analytical (sensitivity of applied methods, standardization) and post-analytical (interpretation of results) phases. EBC analysis is still used as a research tool. Limitations referred to pre-analytical, analytical, and post-analytical phases of EBC analysis are numerous, e.g. low concentrations of EBC constituents, single-analyte methods lack in sensitivity, and multi-analyte has not been fully explored, and reference values are not established. When all, pre-analytical, analytical and post-analytical requirements are met, EBC biomarkers as well as biomarker patterns can be selected and EBC analysis can hopefully be used in clinical practice, in both, the diagnosis and in the longitudinal follow-up of patients, resulting in better outcome of disease.

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Urates in Exhaled Breath Condensate of Children With Asthma: Table 1

Cited by 5 publications

References 16 publications

Urates in exhaled breath condensate of children with obstructive sleep apnea

Urates in exhaled breath condensate of children with obstructive sleep apnea

Association of Asthma Symptoms and Exacerbation with Inflammatory Biomarkers

Exhaled breath condensate – from an analytical point of view

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