Current data about the degradation of organophosphorus pesticides in animal, plant and soil substrates and the environment are summarized in this report. Comparative metabolic and chemical studies with racemic and optically active enantiomers are reviewed. These reactions piovide an understanding of the stereochemistry involved in the oxidation of the P=S moiety, which is the main in-vivo activating reaction for organophosphorus insecticides. ANIMALS The metabolism of 1C-triazophos [0,0-diethyl O-(1-phenyl-1 ,2,-triazol-3-yl) phosphorothioate was studied in rats after single and repeated oral doses. Four days after the single dose, 76.3% of the total radioactivity had been excreted in the urine and 21.o% in the feces. After the daily application of 12 doses, 69-83.i-% of the labeled material was eliminated in the urine and 3o.9-18.1% in the feces by day 16. Elimination was markedly slower following prolonged application of the insecticide. Unchanged triazophos and 1-phenyl-1,2+-triazol-3-ol were found in the feces, whilst the urine contained urea (ca. 85% of the urinary activity), the glucuronides of 1-phenyl-1,2,1i-triazol-3-ol (ca. 3%), 1-phenylsemicarbazide (ca. 5%) and semicarbazide (ca. 5%) and two unidentified metabolites (1).