Ureaplasma urealyticum and chronic lung disease

Smyth, Alan; Shaw, N J; Pratt, B C; Weindling, A M

doi:10.1007/bf01957534

Cited by 29 publications

(6 citation statements)

References 3 publications

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“…The fundamental question, whether or not U. urealyticum is pathogenic for premature infants, is regularly raised, as can be seen from the conflicting reports in the literature (2,3,8,13). The present study showed that U. urealyticum colonization was associated with both the host defence response and respiratory tract involvement, suggesting the pathogenicity of U. urealyticum in premature infants.…”

Section: Discussionsupporting

confidence: 51%

“…This suggests that U. urealyticum colonization aggravates the acute respiratory disease in the preterm infant. In previous studies, U. urealyticum colonization has been common, especially in immature infants (8), emphasizing the importance of gestational age when analysing prematurity-related symptoms and U. urealyticum colonization. In the present study, U. urealyticum colonization was not significantly associated with gestational age.…”

Section: Discussionmentioning

confidence: 95%

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Clinical relevance of Ureaplasma urealyticum colonization in preterm infants

Ollikainen¹,

Heiskanen-Kosma²,

Korppi³

et al. 1998

SPAE

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A cohort of 78 infants of gestational age less than 34 weeks was examined for Ureaplasma urealyticum colonization and neonatal morbidity. Ureaplasma urealyticum was cultured from nasopharyngeal, endotracheal and blood-culture samples. A child was considered as being colonized if any sample was positive. The children with perinatal U. urealyticum colonization (n = 11; 14%) differed from those with no colonization (n = 67) in two important aspects: (i) they had higher leucocyte counts on the first (18.6 vs 12.4 10(9)) and the second (29.0 vs 15.4 10(9)) days of life (p = 0.01, both days); and (ii) they more often needed high-frequency oscillatory ventilation (45% vs 13%, p = 0.02). This study showed that U. urealyticum colonization is associated with signs of the host defence response together with symptoms of respiratory tract involvement suggesting the pathogenicity of U. urealyticum in premature infants.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 95%

Clinical relevance of Ureaplasma urealyticum colonization in preterm infants

Ollikainen¹,

Heiskanen-Kosma²,

Korppi³

et al. 1998

SPAE

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“…Fourteen controlled studies were found in the MED-LINE search (table 3). In five studies, endotracheal aspirates were taken [5,7,8,11,12]. Seven studies had obtained nasopharyngeal cultures [13][14][15][16][17][18][19].…”

Section: Resultsmentioning

confidence: 99%

“…No ALFA [16] 240 NPA/ETA/ --S No Surface WANG [17] 107 NPA/ETA --S Yes SMYTH [7] 138 ETA S N S N S Yes PAYNE [18] 93 NPA/ETA NS NS S Yes HEGGIE [8] 224 ETA S S N S Yes JONSSON [19] 93 NPA/ETA S S S Yes ILES [12] 40 ETA…”

Section: Ns Ns Nsmentioning

confidence: 99%

“…U. urealyticum colonization has been reported as the cause of prematurity, low birth weight, congenital pneumonia and bronchopulmonary dysplasia (BPD) [2][3][4][5]. However, the association with BPD is controversial, because in several studies this association was not significant; and both BPD and Ureaplasma are associated with prematurity and low birth weight [2,[6][7][8]. The aim of the present study was to determine the association between the presence of U. urealyticum in endotracheal aspirates and BPD after correction for gestational age.…”

mentioning

confidence: 99%

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Ureaplasma urealyticum colonization, prematurity and bronchopulmonary dysplasia

Waarde¹,

Brus²,

Okken³

et al. 1997

Eur Respir J

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The aim of the present study was to determine the association between the presence of Ureaplasma urealyticum in endotracheal aspirates and bronchopulmonary dysplasia (BPD). In addition, a review of similar studies from the English literature is presented. During the period February 1990 until March 1991, 108 mechanically-ventilated infants were included in a prospective study. Endotracheal aspirates were cultured for U. urealyticum. Birth weight, gestational age and development of BPD was recorded. Cultures were positive in 23 infants, resulting in a 21% colonization. The infants with positive cultures had a significantly lower gestational age (mean 28.9 vs 31.5 weeks; range 25-40 vs 25-42 weeks; p=0.0014). A positive U. urealyticum culture was not associated with a low birth weight (mean 1,390 vs 1,690 g; range 675-4,090 vs 700-3,600 g; p=0.0712). A positive U. urealyticum culture was significantly associated with BPD (p=0.0373). However, after correction for gestational age by logistic regression analysis, BPD failed to correlate with the presence of positive U. urealyticum cultures. A MEDLINE search of the English language literature was performed to identify all studies having the association of U. urealyticum colonization and BPD. Fourteen controlled studies were found. Five studies found no significant association between U. urealyticum colonization and BPD. In two studies, after correction for gestational age, the association between U. urealyticum colonization and BPD did not remain significant. In five studies with a significant association between U. urealyticum colonization and BPD, no correction for gestational age had taken place. In conclusion, U. urealyticum colonization is not associated with the development of bronchopulmonary dysplasia. U. urealyticum is often associated with gestational age and/or low birth weight; to investigate the association between U. urealyticum and bronchopulmonary dysplasia correction for both parameters should be made.

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PerinatalUreaplasma Urealyticum infection increases the need for hospital treatment during the first year of life in preterm infants

Ollikainen

2000

Pediatr. Pulmonol.

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Ureaplasma urealyticum and chronic lung disease

Cited by 29 publications

References 3 publications

Clinical relevance of Ureaplasma urealyticum colonization in preterm infants

Clinical relevance of Ureaplasma urealyticum colonization in preterm infants

Ureaplasma urealyticum colonization, prematurity and bronchopulmonary dysplasia

PerinatalUreaplasma Urealyticum infection increases the need for hospital treatment during the first year of life in preterm infants

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