Ureaplasma urealyticum colonization and bronchopulmonary dysplasia: a comparative prospective multicentre study

Abele‐Horn, Marianne; Genzel‐Boroviczény, Orsolya; Uhlig, Till; Zimmermann, A.; Peters, J.; Scholz, Michael

doi:10.1007/s004310050987

Cited by 56 publications

(27 citation statements)

References 22 publications

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“…are the most common microbes isolated from infected amniotic fluid, placentas, and the respiratory tracts of preterm infants and their ability to induce inflammation in these sites is undeniable (2,44,45,47,150,339). Knowledge of the biology of ureaplasmas and their behavior in the respiratory tract of preterm neonates suggest that lung disease associated with these organisms is not necessarily due to direct damage from the bacteria themselves, but rather because of their potent stimulation of proinflammatory cytokines (TNF-␣, IL-1␤, and IL-8) or perhaps blockage of counterregulatory cytokines (IL-6 and 1L-10).…”

Section: Association Of Ureaplasma Spp With Development Of Chronic Lmentioning

confidence: 99%

“…The studies were also grouped by definition of BPD, oxygen requirement at 28 days postnatal age (BPD28) and/or 36 weeks postmenstrual age (BPD36). Twenty-three articles reported Ureaplasma colonization and BPD28 (2,6,7,13,45,49,62,89,109,111,123,128,134,137,208,209,215,216,241,247,250,307,329) and eight reported BPD36 (49, 89, 109, 111, 127, 208, 209, 216). There were 2216 infants included in the BPD28 group and 751 infants in the BPD36 group.…”

Section: Association Of Ureaplasma Spp With Development Of Chronic Lmentioning

confidence: 99%

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Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Katz²,

2005

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SUMMARY The genital mycoplasmas represent a complex and unique group of microorganisms that have been associated with a wide array of infectious diseases in adults and infants. The lack of conclusive knowledge regarding the pathogenic potential of Mycoplasma and Ureaplasma spp. in many conditions is due to a general unfamiliarity of physicians and microbiology laboratories with their fastidious growth requirements, leading to difficulty in their detection; their high prevalence in healthy persons; the poor design of research studies attempting to base association with disease on the mere presence of the organisms in the lower urogenital tract; the failure to consider multifactorial aspects of diseases; and considering these genital mycoplasmas only as a last resort. The situation is now changing because of a greater appreciation of the genital mycoplasmas as perinatal pathogens and improvements in laboratory detection, particularly with regard to the development of powerful molecular nucleic acid amplification tests. This review summarizes the epidemiology of genital mycoplasmas as causes of neonatal infections and premature birth; evidence linking ureaplasmas with bronchopulmonary dysplasia; recent changes in the taxonomy of the genus Ureaplasma; the neonatal host response to mycoplasma and ureaplasma infections; advances in laboratory detection, including molecular methods; and therapeutic considerations for treatment of systemic diseases.

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Section: Association Of Ureaplasma Spp With Development Of Chronic Lmentioning

confidence: 99%

Section: Association Of Ureaplasma Spp With Development Of Chronic Lmentioning

confidence: 99%

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Katz²,

2005

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“…Ureaplasma has been isolated from blood, cerebrospinal fluid, tracheal aspirates, and lung tissue of newborn infants (30,44). Respiratory tract colonization in preterm infants has been associated with a high incidence of pneumonia (10,32), severe respiratory failure and death (30), and the development of bronchopulmonary dysplasia (BPD) (1,35,47). Some serovars have been implicated in adverse pregnancy outcomes more commonly than others (2,16,19,49).…”

mentioning

confidence: 99%

Characterization of a Murine Model ofUreaplasma urealyticumPneumonia

Viscardi¹,

Kaplan²,

et al. 2002

Infect Immun

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Ureaplasma urealyticum respiratory tract colonization in preterm infants has been associated with a high incidence of pneumonia and the development of bronchopulmonary dysplasia. However, study of this human pathogen has been hampered by the absence of animal models. We have developed the first juvenile mouse model of Ureaplasma pneumonia and characterized the histopathology during the month following inoculation. C3H/ HeN mice were inoculated intratracheally with a mouse-adapted clinical Ureaplasma isolate (biovar 2) or sham inoculated with 10B broth. Culture of lung homogenates and PCR of DNA from bronchoalveolar lavage fluid (BAL) confirmed the presence of Ureaplasma in 100% of inoculated animals at 1 day, 60% at 2 days, 50% at 3 days, and 25% at 7 and 14 days. Ureaplasma was undetectable 28 days postinoculation. There were marked changes in BAL and interstitial-cell composition with increased number of polymorphonuclear leukocytes 1 to 2 days and 14 days postinoculation and macrophages at 2 and 14 days postinoculation. The Ureaplasma infection caused a persistent focal loss of airway ciliated epithelium and a mild increase in interstitial cellularity. There were no differences in BAL protein concentration during the first 28 days, suggesting that pulmonary vascular endothelial barrier integrity remained intact. Comparison of BAL cytokine and chemokine concentrations revealed low levels of tumor necrosis factor alpha (TNF-␣) at 3 days and monocyte chemoattractant protein 1 at 7 days in Ureaplasma-infected mice but a trend toward increased TNF-␣ at 14 days and increased granulocyte-macrophage colony-stimulating factor and interleukin-10 at 28 days. These data suggest that Ureaplasma alone may cause limited inflammation and minimal tissue injury in the early phase of infection but may promote a mild chronic inflammatory response in the later phase of infection (days 14 to 28), similar to the process that occurs in human newborns.

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“…Although barotrauma and oxidant injury are important factors in the pathogenesis of BPD (27), there is accumulating epidemiological and biologic evidence that intrauterine and postnatal infections contribute to the initiation and exacerbation of lung inflammation and injury (1,6,18,19,71). It is now important to determine the roles of specific organisms and the mechanisms of injury involved in the development of BPD.…”

mentioning

confidence: 99%

“…Ureaplasma urealyticum is the most common organism isolated from infected amniotic fluid and placentas (17,33,75) and from the respiratory tracts of preterm infants (1). Respiratory tract colonization of the preterm infant with U. urealyticum has been associated with higher incidences of pneumonia (10,45), severe respiratory failure and death (44), and BPD (1,23,29,69).…”

mentioning

confidence: 99%