Urethral pressure reflectometry and pressure profilometry in healthy volunteers and stress urinary incontinent women

Klarskov, Niels; Lose, Gunnar

doi:10.1002/nau.20617

Cited by 24 publications

(19 citation statements)

References 25 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In healthy subjects invasive cystometry has also been tested with contraction of the external urethral sphincter measured using a two‐channel microtip pressure transducer catheter in the rectum and urethra 93. Non‐invasive diagnostic tools used in early clinical trials are measurement of: (a) bladder capacity with ultrasound; (b) maximum flow rate with uroflowmetry; (c) post‐voided residual; (d) voiding efficiency; and (e) urethral opening and closing pressures and elastance in women using urethral pressure reflectometry (UPR) that demonstrates greater sensitivity and less variability that conventional urethral pressure profile approaches 94–96. With UPR the pharmacological effect of noradrenaline‐reuptake inhibitors has been demonstrated and translated into improvements in stress urinary incontinence (SUI) diary symptoms 96…”

Section: Underactive Bladder: Potential Biomarkers Treatments and Tmentioning

confidence: 99%

How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011

Birder

Ruggieri

Takeda

et al. 2012

Neurourology and Urodynamics

View full text Add to dashboard Cite

The urothelium is a multifunctional tissue that not only acts as a barrier between the vesical contents of the lower urinary tract and the underlying tissues but also acts as a sensory organ by transducing physical and chemical stresses to the attendant afferent nervous system and underlying smooth muscle. This review will consider the nature of the stresses that the urothelium can transduce; the transmitters that mediate the transduction process; and how lower urinary pathologies, including overactive bladder syndrome, painful bladder syndrome and bacterial infections, are associated with alterations to this sensory system. In particular, the role of muscarinic receptors and the TRPV channels system will be discussed in this context. The urothelium also influences the contractile state of detrusor smooth muscle, both through modifying its contractility and the extent of spontaneous activity; potential pathways are discussed. The potential role that the urothelium may play in bladder underactivity is introduced, as well as potential biomarkers for the condition that may cross the urothelium to the urine. Finally consideration is given to vesical administration of therapeutic agents that influence urinary tract function and how the properties of the urothelium may determine the effectiveness of this mode of delivery.

show abstract

Section: Underactive Bladder: Potential Biomarkers Treatments and Tmentioning

confidence: 99%

How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011

Birder

Ruggieri

Takeda

et al. 2012

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

“…In recent years, a group from Denmark has been investigating a new technique of measuring urethral function, urethral pressure reflectometry [44][45][46][47][48], and it will be interesting to see whether this development adds anything new to the diagnosis of ISD.…”

Section: Discussionmentioning

confidence: 99%

Is it possible to diagnose intrinsic sphincter deficiency in women?

Hosker¹

2009

Current Opinion in Urology

View full text Add to dashboard Cite

show abstract

“…During the voiding phase, the NO-cGMP signaling pathway is activated in men, allowing efficient voiding through the relaxation of the urethra and prostate (109). Systemic NO augmentation lowers functional bladder outlet resistance very rapidly in men and the NO-cGMP pathway may be a target in the treatment of lower urinary tract symptoms (109).…”

Section: The Role Of No-cgmp In Bladder Physiologymentioning

confidence: 99%

“…Systemic NO augmentation lowers functional bladder outlet resistance very rapidly in men and the NO-cGMP pathway may be a target in the treatment of lower urinary tract symptoms (109). …”

Section: The Role Of No-cgmp In Bladder Physiologymentioning

confidence: 99%

Overactive Bladder Syndrome and the Potential Role of Prostaglandins and Phosphodiesterases: An Introduction

2013

View full text Add to dashboard Cite

In this paper, a general introduction is given, presenting the overactive bladder syndrome (OAB) and its impact on the quality of life and economical burden in patients affected. Moreover, the anatomy, physiology and histology of the lower urinary tract are discussed, followed by a brief overview on the possible role of prostaglandin (PG) and phosphodiesterase type 5 (PDE5) in the urinary bladder. The current literature on the role and distribution of PGE2 and its receptors in the urinary bladder is discussed. In both animal models and in human studies, high levels of signaling molecules such as PG and cGMP have been implicated, in decreased functional bladder capacity and micturition volume, as well as in increased voiding contraction amplitude. As a consequence, inhibition of prostanoid production, the use of prostanoid receptor antagonists, or PDE inhibitors might be a rational way to treat patients with detrusor overactivity. Similarly, prostanoid receptor agonists, or agents that stimulate their production, might have a function in treating bladder underactivity.

show abstract

Urethral pressure reflectometry and pressure profilometry in healthy volunteers and stress urinary incontinent women

Cited by 24 publications

References 25 publications

How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011

How does the urothelium affect bladder function in health and disease?: ICI‐RS 2011

Is it possible to diagnose intrinsic sphincter deficiency in women?

Overactive Bladder Syndrome and the Potential Role of Prostaglandins and Phosphodiesterases: An Introduction

Contact Info

Product

Resources

About